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The autoimmune checkpoint during B cell maturation eliminates self-antigen reactive specificities from the mature B cell repertoire. However, an exception to this rule is illustrated by B-1 cells, an innate-like self-reactive B cell subset that is positively selected into the mature B cell pool in a self-antigen-driven fashion. The mechanisms by which B-1 cells escape central tolerance have puzzle
Scholarly and practitioner interest in the topic of authentic leadership has grown dramatically over the past two decades. Running parallel to this interest, however, have been a number of concerns regarding the conceptual and methodological underpinnings for research on the construct. In this exchange of letters, the cases for and against the current authentic leadership theory are made. Through
The purpose of this paper is to introduce the concept coworkers’ communicative responsibility taking and to test which factors might influence coworkers’ tendency to take communicative responsibility. The study is split into two phases where on exploratory phase consisted of an exploratory factor analysis on 2244 with the aim to find specific latent factors to test in the confirmatory phase. The c
The purpose of this report is to derive lessons from inflation targeting in Sweden for the choice of the future monetary policy regime of Iceland. Swedish inflation targeting has been a success in terms of reducing inflation and inflation volatility, but real economic volatility is not lower compared to previous periods. In addition, financial imbalances have grown rapidly. A key lesson is that th
A Quality Scorecard (QSC) performance measurement model is proposed to evaluate the quality aspects of an organization in Industry 4.0. To design a QSC for the ‘Fourth Industrial Revolution’, we examined existing measures regarding costs of quality items. The measurement system was refined by simplifying duplicate measures and incorporating quality elements considered in recent international stand
Aims: Most benign bladder pathologies are associated with an increase of extracellular matrix (ECM—fibrosis) and may progress from formation of stiffer matrix to a more compliant structure. The aims were to summarize current knowledge of the origins of bladder fibrosis and consequences in bladder function. Methods: A meeting at the International Consultation on Incontinence Research Society 2017 c
In recent decades, better data and methods have become available for understanding the complex functioning of cities and their impacts on sustainability. This review synthesizes the recent developments in concepts and methods being used to measure the impacts of cities on environmental sustainability. It differentiates between a dominant trend in research literature that concentrates on the accoun
1. IntroductionBoth the development of nowadays membrane technology and nutritive sweeteners started in the middle of the 20th century. The development of the asymmetric membranes using phase inversion was pioneered by Loeb and Sourirajan in the 1960-ies, while the discovery of glucose isomerase was a milestone in the commercialisation of high fructose corn syrup in the beginning of the 1970-ies.
Species from the genus Phytophthora are well represented among organisms causing serious diseases on trees. Phytophthora plurivora has been implicated in long-term decline of woodland trees across Europe. Here we present a draft genome sequence of P. plurivora, originally isolated from diseased European beech (Fagus sylvatica) in Malmö, Sweden. When compared with other sequenced Phytophthora speci
The European pulp and paper industry (PPI) directly emits 31.9 Mton CO2 (2016) and indirectly 12.3 and 5 Mton CO2 from purchased electricity and transport respectively. It also accounts for 68 Mton of biogenic CO2 emissions. The PPI is a mature industry with overall stagnating market demand in the past ten years and relatively high levels of recycling. Forest countries like Sweden and Finland domi
Colour–magnitude diagrams (CMDs) are powerful tools that might be used to infer stellar properties in globular clusters (GCs), for example, the binary fraction and their mass ratio (q) distribution. In the past few years, observations have revealed that q distributions of GC main-sequence binaries are generally flat, and a distribution characterized by a strong increase towards q ≈ 1 is not typica
Plastics are efficient materials for many purposes, e.g. packaging and construction, but are also associated with significant problems. These span from littering in forests and oceans, toxicity of additives, to the fundamental dependence on fossil resource for the production of the plastic material. This report aims to give an overview of the challenges for decarbonisation of plastics, i.e. moving
Resistivity measurements in marine environments have already been tested in Norwegian landscapes in in the detection of subsea fracture zones (Lile et al. 1994; Dalsegg, 2012). Yet, most of the produced data have been processed without taking into account the special conditions created by the presence of seawater. Similar studies outside of Norway (Tsourlos et al., 2001; Satriani et al., 2011; Ruc
Cell-replacement therapies have long been an attractive prospect for treating Parkinson disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with Parkinson disease have been variable, in part owing to the limitations of fetal tissue as a cell source, relating to its availability and the lack of possibility for standardization and to variation in methods. Advances
The management of non-muscle-invasive bladder cancer (NMIBC) has evolved from the first reports on bladder endoscopy and transurethral resection to the introduction of adjuvant intravesical treatment. However, disease recurrence and progression remain an ongoing risk, placing a heavy burden on healthcare resources and on patients’ quality of life. Deeper understanding of the molecular basis of the
We determine a counterexample to strong diamagnetism for the Laplace operator in the unit disc with a uniform magnetic field and Robin boundary condition. The example follows from the accurate asymptotics of the lowest eigenvalue when the Robin parameter tends to − ∞.
The PANDA (anti-Proton ANnihiliation at DArmstadt) experiment will be one of the four flagship experiments at the new international accelerator complex FAIR (Facility for Antiproton and Ion Research) in Darmstadt, Germany. PANDA will address fundamental questions of hadron physics and quantum chromodynamics using high-intensity cooled antiproton beams with momenta between 1.5 and 15 GeV/c and a de
