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Background: The purpose of this analysis was to revisit the open US Food and Drug Administration (FDA) inspection list results from clinical trials and show the possibilities of evaluating inspection results between different world regions and explore what aspects of clinical trial deficiencies are most often reported.Aims: The aim of this study was to evaluate inspection results from different re
Background: Evidence-based guidelines are needed for effective delivery of home oxygen therapy to appropriate patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Methods: The multidisciplinary panel created six research questions using a modified Delphi approach. A systematic review of the literature was completed, and the Grading of Recommendations Asse
Cellobiose dehydrogenase (CDH) is a sugar oxidizing enzyme secreted by various species of wood degrading fungi to assist the process of wood degradation. It can oxidise analytically relevant sugars as cellobiose, lactose or glucose leading to a gain of two electrons per sugar molecule. CDH consists of a flavin containing catalytic domain (DH) and a haem containing electron mediating domain (CYT).
An electron beam of very high energy (50–250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (several cm), very large accelerating structures are needed when using conventional radio-frequency technology, whi
BACKGROUND: Preterm birth remains the major risk factor for the development of intraventricular hemorrhage, an injury that occurs in 25% of very low birth weight infants. Intraventricular hemorrhage is thought to be venous in origin and intrinsic thromboses in the germinal matrix are likely to play a triggering role. Antithrombin, a glycoprotein synthesized in the liver, is the major plasma inhibi
This paper presents a combined experiment and identification procedure, well suited to obtain low-order dynamic models of a patients’ response to continuous drug administration. The experiment requires no a priori information and is of very short duration. The identification method provides both a parametric low-order model, and an estimate of the parameter error covariance. It has been demonstrat
The tendency to buy expensive and unnecessary goods is a pattern of consumer behavior that is becoming all too common in our society. We consume luxury items to satisfy practical needs that are already satisfied in the quest toward self-fulfillment, or simply to impress those around us. The phenomenon of “status consumption” has become increasingly evident in modern society. Although conspicuous c
Damsin (1) is a natural sesquiterpene lactone (SL) isolated from Ambrosia arborescens Mill., a plant used in the Andes as antiinflammatory medicine. This natural product is an inhibitor of NF- κB, a protein complex that controls the transcription of many genes in mammalian cells, and has a potential for standing model for the development of new anti-cancer lead structures. In order to improve the
Romance and investment fraud are complex crimes to investigate. Previous research centers around these fraud’s offenders and victims. However, much less attention has been given to the perspectives of the fraud investigators, even though their central role in the investigation and prevention process. The investigators often encounter resistance from victims, due to them being exposed to social man
In this paper we generalize the electricity spot price model of Lucia and Schwartz by a two-factor model with jumps and stochastic volatility. We estimate the model on daily spot price data from the Nordic market using an approach that combines traditional statistical methods with a Markov chain Monte Carlo algorithm. Results show that the model captures most of the trajectorial and the statistica
Popular Abstract in English An algae that has lost its ability to do photosynthesis over the last million years and started to feed on human blood causes about 600.000 death every year, a number equals about 8 times Lund’s present population. This evolved algae named Plasmod- ium falciparum causes Malaria, a tropical disease mainly affecting economically weak regions in Africa. Unlike bacteria or Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 death cases every year. Mainly affected are populations of subtropical countries in Africa and the largest groups of victims are children below the age of 5 years. The fast evolving drug resistances of Plasmodium against the the most pow- erful antimalarials threatens the successful containment of this
Torvald LarssonDomstolsprövning av förvaltningsbeslutSvensk, dansk och österrikisk rätt i komparativ belysningDatum för disputation: fredagen den 11 december 2020Fakultetsopponent: docent Patricia Jonasson, Södertörns högskolaÄmne: offentlig rättAbstractThis thesis contains a comparative study of the systems of judicial review of administrative decisions in Swedish, Danish, and Austrian law. The m
https://www.jur.lu.se/forskning/disputationer/disputationer-2020 - 2026-07-07
This is the second part of a study that is following eight Swedish fathers of very preterm children using qualitative interviews. The aim was to illuminate fathers' lived experience of the 3years since the birth of their very preterm child using a hermeneutic phenomenological method. The fathers described their lived experience as a process of reorganizing life, which constituted the overarching t
Bonus relations (such as step-grandparents, step-grandchildren, and families of choice) can be chosen, or they can be forced up on you, they can be regarded as very important to extremely peripheral. Bonus relations negotiate familiarity and can vary from inclusion to exclusion. Common to bonus-relations are their non-biological aspect: they are not blood-line relations, and to many families and f
