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Molecular Mechanisms in Hematopoietic Stem Cell Aging

Popular Abstract in Swedish Blodet är sammansatt av många olika typer av mogna celler som är ansvariga för specialiserade roller inom blodsystemet. Röda blodceller transporterar syre till kroppens celler, vita blodceller förser oss med försvar mot mikroorganismer och blodplättar ser till att stoppa blödningar. Nybildning av blodceller behövs kontinuerligt eftersom vissa celler lever bara i några dThe blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to provide life-long hematopoiesis. Aging is in ge

Large-eddy simulation on the effect of injection pressure and density on fuel jet mixing in gas engines

Direct injection (DI) natural gas engines are modern engine concepts providing clean combustion and high fuel efficiency. Even at high injection pressures, such engines operate at heterogeneous/stratified fuel/air mixture conditions due to the relatively short mixing time of the fuel jet. The sub-optimal fuel-air mixture results in emissions of unburnt hydrocarbon (UHC). In particular, one of the

Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.

Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances, sleep problems and metabolic dysfunction are part of the disease manifestation. These aspects may relate to changes in the hypothalamus, an area of the brain involved in the regulation of emotion, sleep and metabolism.

On the convergence of discrete time hedging schemes

In the first part of this thesis discrete time hedging is considered. In paper A an adaptive hedging scheme where the hedge portfolio is re-balanced when the hedge ratios differ by some amount, here denoted eta, is investigated. An expression of the normalized expected mean squared hedging error as eta tends to zero is derived. The result is compared to an earlier result on discrete time hedging o

Tryckt vs digitalt

The purpose of this Bachelor thesis is to investigate and explain an ongoing process on the Swedish book- and publishing-market as a result of the new alternative ways of publishing. The investigation concerns questions about what need the electronic publishing fills for the authors compared to traditional publishing, and what happens to the writer’s role when published digitally on self-publishin

Swedish secondary school language teachers’ reflections on principal leadership behaviours

Teachers’ experiences of school leadership behaviour and the social contexts in which these have taken place interest me. I aim to identify and understand what Swedish secondary school language teachers’ reflections are on what they require in terms of leadership from their principals in different contexts in order to gain personal job satisfaction. The objective is that this research can then fun

Speaking for the Marginalised: Representation strategies of the Civil Society Organisations working with marginalised group issues at European level

Participation of Civil Society Organisations (CSOs) has been greatly promoted by the European Union (EU) and many CSOs in social policy sphere in particular have increasingly gained their participatory venues and consultative status vis-a-vis EU institutions since the 90’s. However, their expected role to bring even the most marginalised groups’ voice into European policy making process poses a qu

A Comparative Study on the Situation of the Roma in Romania and Spain: A Focus on multicultural education measures as a foundation for positive societal integration

This thesis addresses the complexities of the situation of the Roma in Romania and Spain and the challenges of including isolated groups in society. The main texts used for comparison come from the Council of Europe’s expert bodies: the European Commission Against Racism and Intolerance (ECRI), the Advisory Committee (ACFC) under the Framework Convention for the Protection of National Minorities (

MAR-drömmen administrativa sanktioner - En undersökning av administrativa sanktioners ändamålsenlighet vid marknadsmanipulationer

Under 2022 hade värdepappersinstitutet Avanza över 1.7 miljoner kunder, och ökade antalet kunde med 100 000 det året. För att försäkra sig om att alla aktörer som handlar med finansiella instrument vill fortsätta handla på marknaden, krävs det att de har förtroende för marknaden. För att aktörerna ska ha förtroende för marknaden är det viktigt alla har tillgång till korrekt information så att de iIn 2022, the securities institute Avanza had over 1.7 million customers, which was an increase by over 100,000 customers that year. To ensure that all actors who trade with financial instruments want to continue to trade, it is crucial that they have confidence in the market. For the parties to have confidence in the market, it is important that everyone have access to correct information so that

Modelling of a Heat Conduction Calorimeter Used in Cement Plant Automation

A model is used to describe a system physically or mathematically and to give information about changes in the system variables. Physical knowledge about the system and its quantities can be useful to build a physical model obeying the laws of nature. However, if the system is to be regarded as a black box with only input and output signals, system identification can be used to fit a mathematical

FindMe Tag - Facilitate rescue efforts during disasters through culture-sensitive design

Over the last decade, 1.8 billion people worldwide have been affected by disasters triggered by natural hazards and 740 000 lives have been lost. Due to climate change, these numbers are predicted to rise dramatically in the upcoming years. In disaster prone areas, remote communities and lower income countries are disproportionately affected and often lack the resources to prepare. Locating victim

Classifying Hypernasality for Children with a Cleft Palate using a Convolutional Neural Network

In Sweden, about 150-200 children annually are born with some form of cleft lip and/or palate, making it the most common facial malformation in the country. Treatment often involves one or more surgeries and the speech development is followed up by a speech pathologist from the first year of life. One of the most common speech deviation for children with a cleft palate is hypernasality, which come

Geografiska informationssystem på internet : en webbaserad GIS-applikation för kalknings- och försurningsinformation i Kronobergs län

Populärvetenskaplig sammanfattning: Geografiska informationssystem på internet är ett relativt nytt fenomen som främst har utvecklats från ett behov att distribuera geografisk data, dvs utbyte av digitala geografiska data och tillhörande tjänster. Men det är även ett kraftfullt verktyg för att presentera information på internet. Detta examensarbete i naturgeografi syftar till att skapa en webbaGIS on the Internet is a rather new phenomenon, which has evolved from the need of distributed geographical data. It is also a powerful tool for presenting information on the Internet. This master thesis aim to create a web based GIS application with information on lime spreading and the situation concerning acidification in the county of Kronoberg, Sweden. The web based GIS application will be us

Småvatten då och nu : en förändringsstudie av småvatten i Skåne och deras kväveretentionsförmåga

Populärvetenskaplig sammanfattning: Småvatten är en svacka eller hålighet som är vattenfylld året om. Dessa småvatten fyller många viktiga funktioner i naturen. De fungerar som utjämnare av flödesvariationer, uppehållsplats och födoplats för många djur och växter och som rena estetiska inslag i naturen, och inte minst som reningsplatser för oönskade näringsämnen så som kväve. Dessa småvatten har iWetlands play an important role in the ecosystem. They reduce the impact of flow flux in the drainage area, acts as upholder of biodiversity, as an esthetic and recreational component in the landscape and they have the ability to reduce nutrients such as nitrogen, and help preventing eutrophication in costal areas. The number of wetlands in Scania have, due to the intensified agriculture been redu

Att göra det avvikande normalt eller Att göra den missbrukande kvinnan till kvinna

My purpose in this essay is to show how the staff in an institution for young women with a drug addiction, are looking at themselves as "normal" and the young women as "abnormal", and to analyse how sex and gender are made, in interaction with sexuality and class. The essay is based on interviews and a participating observation. The study is made on a compulsory institutional

The financial benefits of building ?green? An analysis of New York City high performance law

In New York City, in the United States as a whole, and in the rest of the world, there are many projects with high performance features and environmental ambitions already completed or being built. Unfortunately, few projects are consistently followed-up and evaluated, which means that valuable information is lost. For this reason, this research attempts to gather information from high performanc

Application of Fourier Transforms to time-resolved ambient pressure spectroscopy operando studies of CO oxidation over Pt(111)

The study of heterogeneous catalysis has important implications in increasing the efficiency of industrial processes and in reducing the emissions of greenhouse gases from sources such as automobiles. A reaction with high industrial relevance is the oxidation of CO on noble metal catalysts. In this work I apply Fourier Transformations to Ambient Pressure X-ray and Ultraviolet Photoelectron Spectr

UN vs OECD Model Tax Conventions - An alternative for development through formulary apportionment?

The purpose of this thesis is to evaluate the compatibility of the current dominant approach in international taxation for intragroup transactions, based on arm’s length principle, with international agreements on development. In this sense, the thesis aims to explore the viability of formulary apportionment as an alternative that could reduce contradictions between international tax law and devel