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Model studies of the subtype B and non-subtype B integrases are still required to compare their susceptibility to antiretroviral drugs, evaluate the significance of resistance mutations and identify the impact of natural polymorphisms on the level of enzymatic reactivity. We have therefore designed the consensus integrase of the HIV-1 subtype A strain circulating in the former Soviet Union territo
Popular Abstract in Swedish Två mobila system, ett svenskt och ett italienskt, för undersökning av historiska fasader har använts för att undersöka möjligheten till identifiering av olika material, biologisk påväxt och faktorer som i framtiden kan leda till nedbrytning av kulturhistoriskt värdefulla monument. Undersökningarna visade på möjligheter att genomföra analyser av ytor med hjälp av fluoreThe on-site documentation and examination of architectural heritage has presented challenges for traditional analysis methods in the form of, among other things, large complex structures, sites and environmental conditions. In recent years there has been growing interest in assessing progressing deterioration processes and material analysis, with an emphasis on sustainable conservation and mainten
Popular Abstract in Swedish Benskörhet (osteoporos) är ett tillstånd som definieras av låg benmassa och ökar med stigande ålder. Osteoporos är idag en av de stora folksjukdomarna och man räknar med att en tiondel av alla män och en fjärdedel av alla kvinnor i Sverige drabbas. Tillståndet är i sig symptomfritt men ökar risken att råka ut för ett benbrott (fraktur) redan vid lättare fall. Frakturer The aim of this thesis was to evaluate risk factors for bone fragility and fractures in postmenopausal women in a long-term perspective. The study period spanned from the age of 48 to age 82 and is thus unique in its length. The studied sample was homogeneous and consisted of 390 north European women from a population-based cohort. At the start of the study, general health and lifestyle parameters
A novel volatile microemulsion formed by the catanionic surfactant hexadecyltrimethylammonium octylsulfonate (TA(16)So(8)), heptane and water has been explored as a template for producing nanoparticles of hydrophobic organic materials. Butylated hydroxytoluene (BHT) was employed as the model hydrophobic substance. First, the oil-in-water microemulsion was formed, containing TA16So8 as the single e
Indium Tin Oxide (ITO) thin films with a variety of microstructures were deposited using a large area conventional DC magnetron sputtering system for flat panel displays manufacturing. Highly uniform ITO films with an average thickness of ∼100 ± 3 nm on the ∼0.6 m2 substrate area were obtained. Film structures with small amounts of crystalline sites were produced by room temperature deposition, an
Popular Abstract in Swedish Sköldkörtelhormoner och bröstcancer Insjuknandet i sköldkörtelsjukdomar är liksom bröstcancer vanligast hos kvinnor efter klimakteriet och ett eventuellt samband har diskuterats i över ett sekel. Experimentella studier har visat att sköldkörtelhormoner påverkar både utveckling av normala bröstceller och tillväxt av bröstcancerceller. Det finns också belägg för att sköThyroid hormones and breast cancer-prospective studies on incidence, mortality and prognostic factors The aim of this thesis was to investigate in a prospective design, thyroid hormones in relation to breast cancer risk, mortality and prognostic factors. The association between total triiodothyronine (T3) levels and breast cancer risk was studied in 2185 women with146 incident breast cancer cas
Synaptogenesis, the formation of functional synapses, is a crucial step for the development of the central nervous system. Among the genes involved in this process are cell adhesion molecules, such as protocadherins and neuroligins, which are essential factors for the identification of the appropriate partner cell and the formation of synapses. In this work, we studied the expression and the genet
Coagulation factor V (FV) deficiency is characterised by variable bleeding phenotypes and heterogeneous mutations. To add new insights into the FV genotype-phenotype relationship, we characterised the R1698W change in the A3 domain, at the poorly investigated interface with the A2 domain. The FV R1698W mutation was responsible for a markedly reduced expression level (10% of FV-WT) and specific act
The Geological Society of America has sponsored versions of the geologic time scale since 1983. Over the past 30 years, the Geological Society of America Geologic Time Scale has undergone substantial modifications, commensurate with major advances in our understanding of chronostratigraphy, geochronology, astrochronology, chemostratigraphy, and the geomagnetic polarity time scale. Today, many part
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Kadmium är en giftig metall vilken finns i mat som vi rekommenderas äta mycket av, exempelvis sädesprodukter, grönsaker och skaldjur. Våra matjordar är kontaminerade med kadmium och föroreningen kommer att kvarstå under mycket lång tid framöver. Kadmium skadar framförallt njurarna och skelettet och kan antagligen även orsaAbstract: Cadmium (Cd) is ubiquitous in the environment. Human exposure in non-smokers occurs mainly via intake of healthy food like vegetables, cereals, and shellfish. Adverse health effects on kidney and bone at low-level environmental Cd exposure are well-documented in adults. There is considerable inter-individual variation in both metabolism (toxicokinetics) and toxicity (toxicodynamics) of C
By precipitating a complex salt Ly(OS)(8) of the positively charged protein lysozyme and the anionic surfactant octyl sulfate OS-, one can generate a true ternary system: water-Ly(OS)(8)-NaOS. Using NMR diffusometry and U spectroscopy measurements the thermodynamic parameters of the association processes have been determined. The solubility product of the complex salt, K-s, is 10-(28) M-9.(1) On
Popular Abstract in Swedish Konstant produktion av blodceller i benmärgen krävs för att bibehålla normal syretransport i blodet, sårläkning och ett effektivt immunförsvar. Bakom denna produktion ligger hematopoetiska blodstamceller som regleras av en komplex interaktion mellan dem och deras omgivning. Varje blodstamcell kan med självförnyande celldelningar, där minst en dottercell bibehåller en stHematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. Such slow kinetics during cell division might reflect a
Popular Abstract in Swedish Ljusets minsta kända beståndsdelar kallas fotoner. Enligt kvantmekaniken har dessa egenskaper som normalt förknippas med vågor och samtidigt sådana egenskaper som normalt förknippas med partiklar. Partikelegenskaperna tar sig uttryck i att den minsta mängd ljus som går att mäta är den mängd som motsvaras av en foton. Vågegenskaperna, å andra sidan, visar sig i interfereIn this thesis, aspects of the use of cryogenically cooled rare-earth-ion-doped crystals in the fields of quantum optics and quantum information processing are addressed. The experiments and theoretical considerations referred to in this thesis are based on the coherent transient interaction between light and the ions in the crystals. A photon echo experiment has been performed where faint optica
The level of extracellular calcium has been demonstrated to regulate important physiological processes like cell growth and apoptosis. We demonstrate that in the bladder cancer cell line RT4, an increased extracellular calcium level induces apoptosis and that the HER1 receptor functions as a cell survival factor and delays apoptosis. After 12 h of calcium treatment (10 mM) apoptosis was detected i
Introduction: Osteoarthritis (OA) is one of the most common causes of knee pain, and the most common form ofarthritis. It causes pain and disability, and there is currently no cure. Recent research in knee OA highlights therole of the meniscus in OA pathology. In this thesis, the overall aim was to study the proteome and microstructureof the human meniscus, both in healthy subjects and OA patients
One of the functional proteins in rapeseed-the amphiphilic protein oleosin-could be used to stabilize emulsions. The objectives of this study were to extract oleosins from cold-pressed rapeseed press-cake, optimize the extraction process, and investigate their emulsifying and anti-oxidative capacity. The proteins were recovered from industrially cold-pressed rapeseed press-cake at different alkali
The correct folding of proteins is of paramount importance for their function, and protein misfolding is believed to be the primary cause of a wide range of diseases. Protein folding has been investigated with time-averaged methods and time-resolved spectroscopy, but observing the structural dynamics of the unfolding process in real-time is challenging. Here, we demonstrate an approach to directly
Fluid anomalies were often considered as possible precursors before earthquakes. However, fluid properties at the surface can change for a variety of reasons, including environmental changes near the surface, the response of the superficial fluid system to loads associated with the mechanical nucleation of earthquake fractures, or as a result of transients in fluid flow from the depths. A key prob
In the context of complex intergenerational challenges such as climate change and sustainable development, it is increasingly important for scientists and policy-makers to actively engage with and support the meaningful participation of youth in policy and decision-making. This research evaluates the effectiveness and impact of the Youth in Landscapes Initiative in supporting the active participat
Using unique longitudinal microdata linking administrative records from Sweden and Finland, we study how immigrant naturalization relates to cultural proximity. We analyze how Swedish citizenship acquisition depends on mother tongue by comparing Swedish-speaking and Finnish-speaking immigrants from Finland, who arrived in Sweden in 1988–2004, and contrast with other Nordic-born immigrants. We trea
