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Malignant melanoma is one of the most aggressive tumors which often gives metastasis to distant organs thereby limiting the chances of survival. Brain metastasis occurs in nearly half of the advanced tumors. In order to improve outcome early diagnosis is important. The discovery and better understanding of genetic and epigenetic changes is essential for developing new effective therapies, which ca

Several studies demonstrate the value of residents’ voices in the place branding process, however, relatively little is known about how residents experience participating in place branding campaigns and the consequences for place identity. This chapter explores the question of whether participatory branding initiatives could potentially lead to more inclusionary representational spaces in the city

In this chapter, speech enhancement and echo cancellation for hands-free mobile telephony are discussed. A number of microphone array methods have been tested and results from car measurements are given. Traditional methods such as linearly constrained beamforming and generalized sidelobe cancelers are discussed as well as array gain optimization methods. An in situ calibrated method which gives a

Spectral properties of the weighted Laplace operator in the presence of fractal boundaries are numerically investigated for both Neumann and Dirichlet boundary conditions. This corresponds to the characterization of heat and mass transport in microchannels with irregular and rough surfaces induced by the microfabrication process. The axial velocity field with no-slip boundary conditions, represent

This work presents a digital calibration technique in continuous-time (CT) delta-sigma (Δ Σ) analog to digital converter. The converter is clocked at 144 MHz with a low oversampling ratio (OSR) of only 8. Dynamic element matching is not efficient to linearize the digital to analog converter (DAC) when the OSR is very low. Therefore, non-idealities in the outermost multi-bit feedback DAC are measur

Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabil

Background: The life expectancy of pancreatic cancer patients remains minimal. The disease progression may be influenced by type 2 diabetes (T2D) and inflammatory status, although important gaps persist around their joint effects on disease outcome. The aim of this study was to investigate the clinical significance of the tumour immune microenvironment on pancreatic cancer prognosis in relation to

Background: Atrial fibrillatory cycle length has been considered one of the indices of atrial electrical remodelling during atrial fibrillation (AF), which can be assessed from surface ECG by computer-assisted calculation of atrial fibrillatory rate (AFR). Horses have been suggested as a bona fide model for AF studies since horses too, develop lone AF, however data on AF characteristics in horses

Pancreatic cancer is known for its propensity to metastasize. Recent studies have challenged the commonly held belief that pancreatic cancer is a stepwise process, where tumor cells disseminate late in primary tumor development. Instead it has been suggested that pancreatic tumor cells may disseminate early and develop independently and in parallel to the primary tumor. Circulating tumor cells can

In applications spanning from image analysis and speech recognition to energy dissipation in turbulence and time-to failure of fatigued materials, researchers and engineers want to calculate how often a stochastic observable crosses a specific level, such as zero. At first glance this problem looks simple, but it is in fact theoretically very challenging, and therefore few exact results exist. One

Background Whole-genome sequencing (WGS) of heart transplant recipient- and donor-derived cardiac biopsies may facilitate organ matching, graft failure prediction, and immunotolerance research. The objective of this study was to determine the feasibility of WGS based on formalin-fixed paraffin-embedded endomyocardial biopsies. Methods and results The study included serial donor- and recipient samp

The minimum edge dominating set (MEDS) is one of the fundamental covering problems in graph theory, which finds many practical applications in diverse domains. In this paper, we propose a meta-heuristic approach based on genetic algorithm and local search to solve the MEDS problem. Therefore, the proposed method is considered as a memetic search algorithm which is called Memetic Algorithm for mini

Purpose: Radon is a risk factor for lung cancer and uranium miners are more exposed than the general population. A genome-wide interaction analysis was carried out to identify genomic loci, genes or gene sets that modify the susceptibility to lung cancer given occupational exposure to the radioactive gas radon. Methods: Samples from 28 studies provided by the International Lung Cancer Consortium w

The Amazon Basin is a unique region to study atmospheric aerosols, given their relevance for the regional hydrological cycle and the large uncertainty of their sources. Multi-year datasets are crucial when contrasting periods of natural conditions and periods influenced by anthropogenic emissions. In the wet season, biogenic sources and processes prevail, and the Amazonian atmospheric composition

Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tangles and widespread neuronal loss in the brain. In recent years, blood biomarkers have emerged as a realistic prospect to highlight accumulating pathology for secondary prevention trials. Neurofilament light chain (NfL), a marker of axonal degeneration, is robustly elevated in

Popular Abstract in Swedish Denna avhandling föreslår förbättringar av vissa verktyg som svenska myndigheter använder för samhällssäkerhet och krishantering; krishanteringsutvärderingar, krishanteringsövningar samt organisatoriska riskbedömningar. Avhandlingen undersöker även hur visualiseringar av säkerhetskulturdata kan stödja utveckling av säkerhetskultur. Forskningen motiverades av praktiska bThis thesis suggests improvements of selected parts of the Swedish authorities’ toolkits for societal safety and crisis management; crisis response evaluations, crisis management exercises and organizational risk assessments. The thesis also explores how visualizations of safety culture data can be used to support safety culture development. The research was motivated by practical needs and delive

Laser spectroscopy of free atoms has been pursued for 25 years starting in the visible region and with a constant thrust towards shorter wavelengths. A review of generation schemes and atomic-physics experiments in the short-wavelength region is given. Processes in ions and inner shells occur on a very fast timescale setting special demands on the sources. Using picosecond laser technology efficie

BACKGROUND: Butterflies of the subtribe Mycalesina have radiated successfully in almost all habitat types in Africa, Madagascar, the Indian subcontinent, Indo-China and Australasia. Studies aimed at understanding the reasons behind the evolutionary success of this spectacular Old World butterfly radiation have been hampered by the lack of a stable phylogeny for the group. Here, we have reconstruct