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Under de senaste femtio åren har de europeiska kapitalmarknaderna blivit allt mer integrerade. För att garantera allmänhetens förtroende, för att förhindra framtida finanskriser och för att nå den ekonomiska effektiviteten på marknaden, är det viktigt att det finns harmoniserade förbud mot marknadsmissbruk. En vanlig form av marknadsmissbruk är handel med insiderinformation, som kan leda till stoDuring the last fifty years, the European capital markets have become increasingly integrated. In order to ensure public confidence, to prevent future financial crises and to reach economic efficiency on the market, it is of importance that there are harmonised prohibitions against market abuse. A common form of market abuse on the European market is trading with inside information, which can lea

This Master thesis was conducted at ThyssenKrupp Marine Systems AB (TKMS AB), formerly known as Kockums AB. TKMS AB is based in Malmö, Sweden and is a manufacturer of conventionally powered submarines. The next generation of submarines, type A26, is currently under development and introduces many new features compared to prior submarine designs. Following increased fire and sound reduction demands

Crohn's disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract, and are collectively referred to as inflammatory bowel disease (IBD). IBD is a major cause of lifetime morbidity, has a severe impact on quality of life of patients (equivalent to that of rheumatoid arthritis, asthma, migraine, or diabetes) and constitutes a substantial economic burden to the h

Study objectives: The aim of this study was to develop quality criteria for further development and use in the Medicines Management(MM) process in European hospitals. Methods: Criteria for MM were developed in three steps using a modified two-stage Delphi-technique. In the first step a literature search was performed and 300 topics were listed. These topics were grouped into three dimensions, e

The aspartic protease cathepsin D, a poor prognostic indicator of breast cancer, is abundantly secreted as procathepsin D by human breast cancer cells and self-activates at low pH in vitro, giving rise to catalytically active cathepsin D. Due to a lower extracellular pH in tumor microenvironments compared to normal tissues, cathepsin D may cleave pathophysiological substrates contributing to cance

Background: The number of new cases of type 1 diabetes mellitus (T1DM) has increased substantially in recent years and it is now one of the most common long-term endocrine disorders in childhood. In Sweden the child and family are hospitalised in accordance with the national guidelines for one to two weeks at diagnosis. The purpose of this study was to describe parents' perceptions of the educatio

Research has shown that families experience poor involvement in needs assessment of older people while little is known about municipal care managers' views of family participation. The aim was to explore how municipal care managers view families' participation in and influence on needs assessment of older people receiving public home help. Individual interviews (n = 26) were conducted with care ma

Objective. Several classification systems have been launched to characterize Barrett's esophagus (BE) mucosa using magnification endoscopy with narrow band imaging (ME-NBI). The good accuracy and interobserver agreement described in the early reports were not reproduced subsequently. Recently, we reported somewhat higher accuracy of the classification developed by the Amsterdam group. The critical

The demand from the aircraft industry of light and stiff structures along with fast manufacturing processes has increased through the last decade. This master thesis is carried out at Saab Aeronautics with purpose of developing a new concept for the horizontal stabilizer to the turboprop aircraft SAAB 2000. To specify the project, only the torsion box, including spars, ribs and skins are considere

The following essays checks whether the Swedish stock market (represented by OMXS30) supports the weak efficiency of the EMH by observing whether the stocks contain a unit root and whether one can use trading strategies to create abnormal profits. The AR(1) model of the stock prices have a unit root coefficient very close to 1, thus they are trend stationary but have a very long memory. This model

This paper examines how the returns and volatility of Chinese ADRs listed at NYSE are affected by their host market (US), underlying market (Hong Kong) and local market (Shanghai). Using a GARCH spillover model and data from 1 January 2002 to 30 September 2007, we find that the volatility spillover from US (host market), Hong Kong (underlying market) and Shanghai (local market) to Chinese ADRs, fo

Traditional publishers of journalistic material have found a new channel through which they can reach the readers namely the Internet. The material is often the same in the online version as in the paper based version, but not enough thought has been paid to how the different media influence the way of reading. The Internet as medium imposes new criteria as to how the content should be published.

Individuals with a dismissing-avoidant pattern of attachment are assumed to repress anxiety-related signals, a disposition hypothesized to interfere with facial mimicry and emotional contagion. Further, they are assumed to have one internal working model associated with anxiety, operating out of awareness at early, automatic stages of information processing, and another positive model operating at

The neuropeptide vasoactive intestinal polypeptide (VIP), which is found in a population of cholinergic parasympathetic neurons in the airways, has no effects per se on mucociliary activity. In order to test the hypothesis that VIP may modulate cholinergic regulation of the mucociliary system, VIP was infused intraarterially (8.4 pmol/kg/min), and the response to challenges with methacholine in th

An integrated process for purifying a 6.1 kilo base pair (kbp) plasmid from a clarified Escherichia coli cell lysate based on an ultra/diafiltration step combined with polymer/polymer aqueous two-phase system and a new type of chromatography is described. The process starts with a volume reduction (ultrafiltration) and buffer exchange (diafiltration) of the clarified lysate using a hollow fibre me

Cystatin F is a recently discovered type II cystatin expressed almost exclusively in immune cells. It is present intracellularly in lysosome-like vesicles, which suggests a potential role in regulating papain-like cathepsins involved in antigen presentation. Therefore, interactions of cystatin F with several of its potential targets, cathepsins F, K, V, S, H, X and C, were studied in vitro. Cystat

The long-acting beta 2-agonist salmeterol has been shown in several in vitro studies to produce non-beta-mediated relaxant effects. The aim of the present study was to investigate whether these effects have any relevance in humans in vivo. Thirteen healthy individuals were studied in a randomized, double-blind, cross-over study on five separate days. The subjects were pre-treated orally with eithe