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OBJECTIVES: Testicular germ-cell cancer (TGCC) patients are at risk of developing hypogonadism but no risk factors have yet been defined. METHODS: Blood was collected from 143 TGCC patients (after orchidectomy, prior to further therapy (T0) and 6, 12, 24, 36 and 60 months (T6, T12, T24, T36 and T60) after therapy). Biological hypogonadism (BH) was defined as: serum testosterone below 10 nmol/l and
Kemiska processer som styr cellers beteende – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Kemiska processer som styr cellers beteende 2019-10-28 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Illustration över metastasering av cancerce
https://www.vetenskaphalsa.se/kemiska-processer-som-styr-cellers-beteende/ - 2026-07-07
Background: Lewy body Dementia (LBD) is a well-known neurocognitive disorder in the elderly. The hallmarks of LBD are Parkinsonism without tremor, recurrent and persistent visual hallucinations often with insight, fluctuating cognition and alertness, rapid eye movement (REM) sleep behavior disorder with vivid dreams and violent movements, but relatively preserved memory functions. Nevertheless, LB
Title: Aligning Inventory with Strategic Priorities Across Factory Boundaries – More than moving plates Authors: Lisa Johansson and Johanna Weber Supervisors: Jan Olhager, Professor at Engineering Logistics, Faculty of Engineering(LTH) at Lund University Alexandra Kristensson, Head of S&OP, GPHE at Alfa Laval AB Examiner: Louise Bildsten, Senior Lecturer at Engineering Logistics, Faculty of
Osteoarthritis is a multifactorial degenerative disease characterized by the breakdown of articular cartilage (AC), affecting hundreds of millions of people worldwide. Among many treatment options, hydrogels have emerged as promising candidates for cartilage replacement, due to their structural resemblance to the native tissue. Hydrogels can be made from various materials, and this study focuses o
Background: Quantitative fecal immunochemical test (FIT) is widely used for colorectal cancer (CRC) screening, with substantial variation in positivity thresholds across countries. This study examines how these thresholds affect FIT's diagnostic performance for detecting CRC and advanced precancerous lesions (APCL). Methods: We analyzed data from a single round screening of 7398 men and women aged
Background: As the survival rate of preterm infants continues to rise worldwide, more infants are at risk of developing sight-threatening retinopathy of prematurity (ROP). Destructive retinal laser treatment and intravitreal injections of anti-vascular endothelial growth factor (VEGF), factor, which have potential systemic side effects, are necessary to prevent blindness in severe cases of ROP. Of
Background: Reliable data on optimal fluid management in the perioperative period for patients with advanced ovarian cancer undergoing cytoreductive surgery is limited. These patients often present with malignant ascites and are prone to significant fluid shifts perioperatively. For this reason, our objective was to define clinical targets for optimal fluid balance and determine whether initial as
Objective. To evaluate an intervention involving advance provision of emergency contraceptive pills (ECP) to Swedish teenage girls. Material and methods. Some 420 girls aged 15-19, requesting ECP at a local youth clinic were randomly assigned to intervention group (IG) (n=214) or control group (CG) (n=206). Both groups received ECP on request. The IG received one extra dose of ECP, condoms and an Objective. To evaluate an intervention involving advance provision of emergency contraceptive pills (ECP) to Swedish teenage girls. Material and methods. Some 420 girls aged 15–19, requesting ECP at a local youth clinic were randomly assigned to intervention group (IG) (n = 214) or control group (CG) (n = 206). Both groups received ECP on request. The IG received one extra dose of ECP, condoms and
Introduction: Food systems strongly influence both human and planetary health. Unhealthy diets aremajor risk factors for chronic disease and mortality, while food production contributes substantially togreenhouse gas emissions (GHGE), and other negative environmental impacts. Adopting moresustainable dietary patterns, such as the EAT-Lancet diet, has been proposed as part of the solution, butuncer
Introduction: Different strategies in prophylaxis for haemophilia among countries may affect long-term outcome. Aim: The aim of this study is to compare joint health in persons with severe haemophilia (PwSH) between Sweden and Greece, based on different approaches on prophylaxis initiation and management. Methods: Data were extracted from the PedNet Registry, which collects patient data prospectiv
Objectives: Within the first phase of developing classification criteria for Early-stage Symptomatic Knee Osteoarthritis, among individuals with knee osteoarthritis (OA) we explored: 1) symptoms within the first year of noticing their knee(s); 2) features that indicated OA was the cause; and 3) timing and reasons that initially prompted seeking healthcare. Design: We conducted a cross-sectional on
Forest conservation has emerged as a key strategy to achieve global climate goals, yet many forest-rich countries remain underfunded. Cambodia, despite its extensive forest cover and high deforestation rates, accesses only a small portion of climate finance to support national mitigation efforts. Developing countries such as Cambodia access only a small share of the substantial annual for national
Background: Perlecan is a heparan sulfate proteoglycan (HSPG) constituent of the extracellular matrix with roles in cell growth, differentiation, and angiogenesis. The role of the HS side chains in regulating invivo angiogenesis after hind-limb ischemia is unknown. Methods: Heparan sulfate (HS)-deficient perlecan (Hspg2 δ3/δ3
PURPOSE: To study newly diagnosed glaucoma patients given mono- or multi-therapy regarding differences in initial intraocular pressure (IOP) reduction, target IOP levels reached and influence of untreated baseline IOP on IOP reduction.METHODS: Patients newly diagnosed with manifest primary open-angle glaucoma and included in the Glaucoma Intensive Treatment Study (GITS) were randomized to immediat
Background and purpose - Treatment of Dupuytren's contracture (DC) with collagenase Clostridium histolyticum (CCH) consists of injection followed by finger manipulation. We used a modified method, injecting a higher dose than recommended on the label into several parts of the cord, which allows treatment of multiple joint contractures in 1 session and may increase efficacy. We studied the occurren
The aim of this sociology of law-orientated article is to analyse and describe legislative and regulatory processes concerning the task given to schools focusing on environment and sustainable development. We are describing the policy-making processes in this field from 1990 to 2011. The study involves key interviews and content analysis of national policy documents as well as legal sources, in or
Makasae is a non-Austronesian / Papuan language spoken by a population of some 70,000 in the newly independent state of East Timor. Because of its long history of occupation and civil war, the nation’s languages are so far sparsely documented. The present work is the first Makasae grammar description to be published in English. Makasae is largely isolating in structure, and its grammar has in man
BACKGROUND: The 30-item disabilities of the arm, shoulder and hand (DASH) questionnaire is increasingly used in clinical research involving upper extremity musculoskeletal disorders. From the original DASH a shorter version, the 11-item QuickDASH, has been developed. Little is known about the discriminant ability of score changes for the QuickDASH compared to the DASH. The aim of this study was to
The denitrification process was studied in a stirred lab-scale suspended carrier biofilm reactor at low temperatures (3–20°C). The reactor was filled to 50% with Kaldnes K1 carriers. The denitrification rate showed only a rather weak dependence on the temperature, the rate at 3°C being approximately 55% of that at 15°C. The maximum denitrification rate obtained at 15°C was 2.7 g NOx−-N m−2 carrier
