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Isolating fragile and heterogeneous cell populations from complex tissues remains a core challenge in biomedical research. In the bone marrow (BM), bone marrow adipocytes (BMAds) are key regulators of hematopoiesis and metabolism, yet their large size, fragility, and lack of specific surface markers have hindered their isolation using conventional methods such as fluorescence-activated cell sortin
Objectives: To compare in an in vitro kinetic model the pharmacodynamics of moxifloxacin and levofloxacin with a concentration-time profile simulating the human free non-protein bound concentrations of 400 mg moxifloxacin intravenous (iv) once daily, 500 mg levofloxacin iv once daily and 750 mg levofloxacin iv once daily against strains of Streptococcus pneumoniae, Staphylococcus aureus, Klebsiell
Resveratrol (RSV), polyphenol from grape, was studied to evaluate its effects on calorimetric parameters, energy metabolism, and antioxidants in the myocardium of diabetic rats. The animals were randomly divided into four groups (n = 8): C (control group): normal rats; C-RSV: normal rats receiving RSV; DM: diabetic rats; and DM-RSV: diabetics rats receiving RSV. Type 1 diabetes mellitus was induce
Purpose Adjuvant carboplatin is one of three management strategies that may follow inguinal orchiectomy in clinical stage I seminoma. However, little is known about the outcome of patients who experience a relapse after such treatment. Patients and Methods Data from 185 patients who relapsed after adjuvant carboplatin between January 1987 and August 2013 at 31 centers/groups from 20 countries were
Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelial and renal function among cancer-free older adults. We analyzed 5167 cancer-free controls aged 40–80 years f
Background: Historically, endocrine therapy was used in a range of scenarios in patients with rising PSA, both as a treatment for locally advanced non-metastatic prostate cancer and PSA recurrence following curative intended therapy. In the present study the objective was to investigate if chemotherapy added to endocrine therapy could improve progression-free survival (PFS). Materials and Methods:
PowerPoint Presentation LBIC Nikon confocal A1+ Standard operating procedure Version 1.2 June 2019 (1) Motorized stage power Brightfield lamp power A1 controller Laser on/off key Laser buttons (2) Turning on/off the system 1. Turn on computer 2. Power on A1 controller and laser power supply. 3. Turn the key and select the needed lasers by pressing the buttons. 4. Turn on stage power supply and DIA
https://www.lbic.lu.se/sites/lbic.lu.se/files/sop_nikon_a1_confocal_v1.2.pdf - 2026-07-03
Dreams & Discoveries LTH / FACULTY OF ENGINEERING / LUND UNIVERSITY Content: A place for dreams and discoveries............... 3 To benefit the climate..................................... 8 To benefit digitalization............................... 12 To benefit Industry........................................ 16 To benefit the built environment................ 20 To benefit life...................
https://www.lthin.lth.se/sites/lthin.lth.se/files/2025-05/Dreams%20and%20discoveries-compressed.pdf - 2026-07-03
LUCSUS Annual Report 2022 Annual Report 2023 LUND UNIVERSITY CENTRE FOR SUSTAINABILITY STUDIES (LUCSUS) 3LUCSUS ANNUAL REPORT 2023 Editors: Noomi Egan Cover illustration: Catrin Jakobsson Lund University Photo: page 5: UN Climate Change/Kiara Worth, page 6: Peter Kornacher, also photos by Cecilia von Arnold and Noomi Egan. Words from the director While new to my role as di- rector, I have had the
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-04/LUCSUS%20AR%202023_high.pdf - 2026-07-03
GEOM10 2018 Overall, I was satisfied with the quality of this course. Overall, I was satisfied with the quality of this course. Number of Responses 1 0 (0.0%) 2 0 (0.0%) 3 2 (18.2%) 4 4 (36.4%) 5 5 (45.5%) Total 11 (100.0%) Mean Standard Deviation Overall, I was satisfied with the quality of this course. 4.3 0.8 Clear Goals and Standard I usually had a clear idea of where I was going and what wa
https://www.geology.lu.se/sites/geology.lu.se/files/geom10_2018_evaluation.pdf - 2026-07-03
1 Information to field workers at CEC 2021 The coordinator’s administrative responsibilities: It is necessary to plan well ahead of time! Consider all the points in this document and decide what you need to do in order for the fieldwork to be successful. Be sure to act in time, whether it is contracting staff, making purchases, hiring cars, contacting CEC-administrators for assistance or what else
https://www.cec.lu.se/sites/cec.lu.se/files/2021-03/Information%20to%20field%20workers%20at%20CEC%202021.pdf - 2026-07-03
- A Ph.D. Defense Interview with Magdalena Madej RNA plays a central role in our cells, carrying genetic information and keeping cellular processes running smoothly. Magdalena Madej, a Ph.D. student at Lund University’s Lund Stem Cell Center, has spent her doctoral studies investigating how RNA-modifying enzymes, called pseudouridine synthases, influence these processes, and what happens when they
To improve the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis. Epigenetic mutations take place at the earliest stages of tumorigenesis and therefore offer new approaches for detecting and diagnosing disease. Nucleosomes are the repeating subunits of DNA and histone proteins that constitute human chromatin. Because of their release i
Immobilized lipase from Candida antarctica lipase B (Novozym 435) was effective in the synthesis of lysophosphatidylcholine (LPC). The transesterification of L-α-glycerophosphorylcholine (GPC) and vinyl laurate was carried out in a solvent free system or in the presence of 50% (v/v) t- butanol. High conversions (>95%) were easily achieved. The lipase was selective for the sn-1 position of the glyc
This study presents an in-depth exploration into the utilization of Variational Autoencoders (VAEs) for modeling and completing implied volatility surfaces within the context of the index equities market, a crucial aspect of option pricing. Moreover, our study examines the predictive capabilities of neural networks concerning fluctuations in spot prices, with a specialized spot model calibrated to
In this manuscript, a new strategy has been reported for circumscribed covalent attachment of barbed and pointed ends of actin filaments to polystyrene beads. A comparative study of attachment of actin filaments to polystyrene beads was performed by blocking functionally active sites on polystyrene beads with nonionic detergents such as Tween 20, Tween 80 and polyethylene glycol (PEG). Effective b
This work presents a regional climate model, the Rossby Centre regional Atmospheric model (RCA1), recently developed from the High Resolution Limited Area Model (HIRLAM). The changes in the HIRLAM parametrizations, necessary for climate-length integrations, are described. A regional Baltic Sea ocean model and a modeling system for the Nordic inland lake systems have been coupled with RCA1. The cou
Steric clashes pose a challenge when exploring dense protein systems using conventional explicit-chain methods. A minimal example is a single lattice protein confined on a minimal grid, with no free sites. Finding its minimum energy is a hard optimization problem, with similarities to scheduling problems. It can be recast as a quadratic unconstrained binary optimization (QUBO) problem amenable to
Allogeneic haematopoietic stem-cell transplantation (HSCT) is frequently applied as part of the treatment in patients with acute myeloid leukaemia (AML) in their first or subsequent remission. Allogeneic HSCT reduces relapse, but nonrelapse mortality and morbidity might counterbalance this beneficial effect. Here, we review recent studies reporting new disease-specific prognostic markers, in addit
