Filtyp
Measurements of the hygroscopic properties of sub-micrometer atmospheric aerosol particles were performed with hygroscopic tandem differential mobility analysers (H-TDMA) at 5 sites in the subtropical north-eastern Atlantic during the second Aerosol Characterization Experiment (ACE-2) from 16 June to 25 July 1997. Four of the sites were in the marine boundary layer and one was, at least occasional
Purpose: Although adjuvant polychemotherapy improves outcomes for early breast cancer, the significant variability in terms of pharmacokinetics results in differences in efficacy and both short and long-term toxicities. Retrospective studies support the use of dose tailoring according to the hematologic nadirs. Methods: The SBG 2004-1 trial was a randomized feasibility phase II study which assesse
Background: beta-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. Methods: We examined the association between rs10993994 genotype and MSP l
Various samples of the solid solution Gd2NixCu2-xMg were synthesized from the elements in sealed tantalum ampoules in an induction furnace. All members crystallize with the tetragonal Mo2FeB2 type structure, space group P4/mbm, and they were characterized on the basis of Guinier powder patterns and energy dispersive X-rays analyses. The lattice parameters decrease with increasing nickel content in
It is now becoming increasingly clear that free radicals contribute to brain damage in several conditions, such as hyperoxia and trauma. It has been more difficult to prove that free radical production mediates ischemic brain damage, but it has often been suggested that it may be a major contributor to reperfusion damage, observed following transient ischemia. Recent results demonstrate that cereb
Despite the favorable prognosis of childhood acute lymphoblastic leukemia (ALL), a substantial subset of patients relapses. Since this occurs not only in the high risk but also in the standard/intermediate groups, the presently used risk stratification is suboptimal. The underlying mechanisms for treatment failure include presence of genetic changes causing insensitivity to the therapy administere
Coherent extreme ultraviolet (XUV) light sources are necessary for the investigation of physical processes in the natural length and time scales of atoms. These experiments require a high degree of control of the coherent XUV light. The optical components and techniques, which are available for visible and infrared light, unfortunately cannot be used for controlling XUV light. In this thesis, nove
Perioperative hyponatremia, due to non-osmotic release of the antidiuretic hormone arginine vasopressin, is a serious electrolyte disorder observed in connection with many types of surgery. Since blood loss during surgery contributes to the pathogenesis of hyponatremia, we explored the effect of bleeding on plasma sodium using a controlled hypotensive hemorrhage pig model. After 30-min baseline pe
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has
A number of 'freedom of religion v. secular policies' cases in the European Court of Human Rights (and, before 1998, the European Commission of Human Rights) emanating from Turkey suggest that the Court endorses Turkish secular policies at the expense of Turkish Muslims' human rights. These cases include the high-profile case of Leyla Ş&semicahin v. Turkey that was decided
Halide perovskites have continued to rise as attractive light absorber materials, mainly driven by their potential wide applications in the fields of solar cells, photodetectors, lasers and others. However, Pb-containing perovskites are poisonous and could cause serious potential problems to our environment. Thus, there is a strong desire to develop lead-free perovskites as environmentally friend
Context: Clinical sequelae of androgen deficiency share common features with frailty. Evidence supporting the role of androgens in the development of frailty is limited and conflicting. Objective: To determine associations between male reproductive hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective cohort study of community-dwelling men participating in the
We investigate the mechanical unfolding of the tenth type III domain from fibronectin (FnIII(10)) both at constant force and at constant pulling velocity, by all-atom Monte Carlo simulations. We observe both apparent two-state unfolding and several unfolding pathways involving one of three major, mutually exclusive intermediate states. All three major intermediates lack two of seven native beta-st
Purpose: To evaluate adjuvant chemotherapy and interpolated accelerated radiotherapy (RT) for adult patients with high-risk soft tissue sarcoma in the extremities or trunk wall. Methods and Materials: High-risk soft tissue sarcoma was defined as high-grade malignancy and at least two of the following criteria: size >= 8 cm, vascular invasion, or necrosis. Six cycles of doxorubicin and ifosfamide w
Hemoglobin (Hb) is well protected inside the red blood cells (RBCs). Upon hemolysis and when free in circulation, Hb can be involved in a range of radical generating reactions and may thereby attack several different biomolecules. In this study, we have examined the potential damaging effects of cell-free Hb on plasmid DNA (pDNA). Hb induced cleavage of supercoiled pDNA (sc pDNA) which was proport
Background. Reconstruction of the right ventricular outflow tract with a conduit is an established surgical procedure in congenital heart disease and reinterventions are common. Objective. An increasing number of patients have a conduit, but there are few population-based studies of long-term outcomes after conduit surgery, reoperations, and transcatheter pulmonary valve replacement. Methods. In A
Amyloida fibriller är aggregat av självassocierande proteiner som tillsammans skapar ett tätpackat inre med hög ordningsgrad. Dessa fibriller är ofta förknippade med neurodegenerativa sjukdomar, t.ex. Alzheimers- och Parkinsons sjukdom. I dagsläget saknas botemedel för dessa sjukdomar och därav finns det intresse för att studera amyloida fibriller. Grundläggande forskning om exempelvis fibrillernaAmyloid fibrils are aggregates of self-assembled peptides and proteins that forms a highly ordered and densely packed core of β-strands stacking perpendicular to the length of the fibril. Amyloid fibrils of the protein α-synuclein (α-syn) are associated with Parkinson’s disease. This study aims at contributing to the physiochemical basis of α-synuclein aggregation and dissolution, mainly in terms
Measuring pharmacokinetic properties is notoriously difficult. The invitro/ex vivo laboratory experiments seek to mimic the physiological responses of the body to the drug, but it rarely gives a good estimate of what happens in vivo. Lipophilicity is traditionally measured by the shake-flask method,in which the distribution of the analyte between two immiscible phases (one organic, one aqueous) is
