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AIMS: Exosome-mediated microRNA transfer is a recently discovered mode of cell-to-cell communication, in which microRNAs act as paracrine molecules, exerting their regulatory effects in recipient cells. T cells and endothelial cells are two main players in the mechanism of acute cellular cardiac rejection. The aim of this study was to investigate the role of exosomal microRNAs in the crosstalk bet
Many bacteria have the ability to interact with antibodies as a means to circumvent the immune response. This includes binding to the Fc portion of antibodies, effectively reversing the antibody orientation and thus decreasing the Fc-mediated immune signaling. Since antibody orientation at the bacterial surface has been shown to be important in human disease, it is valuable to be able to assess ho
Neutrophils have an incredible ability to find and eradicate intruders such as bacteria and fungi. They do this largely through the process of phagocytosis, where the target is internalized into a phagosome, and eventually destroyed by the hostile phagosomal environment. It is important to study phagocytosis in order to understand how neutrophils interact with various pathogens and how they respon
While the nano-sized energetic materials are featured with ultra-high energy density, the ubiquitous agglomeration in their combustion is still unexplored. In this paper, the combustion characteristics of aluminum nanoparticle agglomerates in the size range of 4-20μm are investigated on a modified Hencken burner with different temperature (800-1800K) and oxygen concentration (0.5-5.5mol/m3). Due t
This paper presents the results of an observation study of interactions between bicyclists and buses on shared bus lanes. The aim of the paper is to analyse bicyclists' safety on bus lanes shared with bicyclists. Straight sections of two bus lanes shared with bicyclists in Belgium are observed. All interactions between bicyclists and buses over two full weeks are recorded and analysed. Additionall
Microscopy is an essential tool for studying bacteria, but is today mostly used in a qualitative or possibly semi-quantitative manner often involving time-consuming manual analysis. It also makes it difficult to assess the importance of individual bacterial phenotypes, especially when there are only subtle differences in features such as shape, size, or signal intensity, which is typically very di
In the Fall of 1977, The Institute of Economics at the University of Lund arranged a symposium on the theoretical contributions of Knut Wicksell and the subsequent development of his ideas by other theorists. The symposium was financed by the Arne Ryde Foundation. The aim of the symposium was to examine the effects of Wicksell's ideas on the development of economic theory and to discuss the assert
The type III receptor tyrosine kinase FLT3 is one of the most commonly mutated oncogenes in acute myeloid leukemia (AML). Inhibition of mutated FLT3 in combination with chemotherapy has displayed promising results in clinical trials. However, one of the major obstacles in targeting FLT3 is the development of resistant disease due to secondary mutations in FLT3 that lead to relapse. FLT3 and its on
The Fiskarheden quarry, situated in NW Dalarna, central Sweden, reveals thick coarse-grained sediments of Scott type facies association representing a sandur deposited in an ice-proximal proglacial environment. Optically Stimulated Luminescence (OSL) dating of the sandur sediments suggests a pre-Last Glacial Maximum (LGM) age. Most acquired ages are pre-Saalian (>200 ka) and we regard each of thes
Volymen lyfter fram några aspekter av hur kyrkoåret har uppfattats, främjats och reviderats under det senaste seklet. Artiklarna belyser kyrkoårets gestaltning i predikoutkast, evangeliebok, folklig sed, sång, musik och liturgiska textilier. Dessutom finns en fyllig recensionsavdelning.
Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to define the heterogeneity within the LSC-population in chronic phase chronic myeloid
Background: Residual air accumulated air in the pulmonary veins constitutes a challenge to achievment of complete de-airing in open left heart surgery. To adress this problem, a conceptual method for de-airing was developed in Lund comprising bilateral opening of the pleurae to induce pulmonary collapse and a strategy with gradual pulmonary reperfusion and ventilation at weaning from cardiopulmona
Artikeln analyserar hur Augustinus i Sermo 9 hanterar människolivets paradoxer och svårigheter i relation till Guds löfte om evigt liv.Augustine mainly addressed men of the upper and middle classes. Their wives are assumed to be present (and, frequently, to be more pious than their husbands), but are seldom directly addressed. Servants and beggars are not addressed either, but stood to benefit from admonitions to the men in the audience, e.g. that they should give alms regularly and not sexually abuse their subordinates. All this
A survey of the Latin Lives of St Birgitta of Sweden, with an edition of a brief life found in an English ms. and another found in two Italian mss., both previously unedited. Also a re-edition of the Life found in the first edition of St Birgitta's Revelations, published in 1492.
Python can be used for more than just general-purpose programming. It is a free, open source language and environment that has tremendous potential for use within the domain of scientific computing. This book presents Python in tight connection with mathematical applications and demonstrates how to use various concepts in Python for computing purposes, including examples with the latest version of
