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Antiviral therapy in hepatitis C virus (HCV) infection is limited by haematological side-effects, especially thrombocytopenia and leucopenia. The pancytopenia associated with liver cirrhosis has multifactorial causes, but hypersplenism seems to be a major contributor, especially regarding thrombocytopenia. The use of PSE as a 'Pretreatment' in order to make more patients with HCV-induced cirrhosis

Until recently fish welfare attracted little attention, but international and national legislation and standards of fish welfare are now emerging and an overview of these developments is presented in this study. Whereas animal welfare legislation is based on public morality, animal ethics does not automatically accept public morality as normative and elaborates arguments regarding the way humans s

Parenthood is often considered a major factor behind gender differences in time allocation, especially between paid work and housework. This article investigates the impact of parenthood on men's and women's daily time use in Sweden and how it changed over the 1990s. The analysis is made using time diary data from the Multinational Time Use Survey (MTUS; N = 13,729) and multivariate Tobit regressi

Objective To evaluate the association between objectively measured daily Study design Cross-sectional, observational, study of 248 children aged 7.9 to 11.1 years. Abdominal fat mass and total body fat mass were measured by dual-energy X-ray absorptiometry. Daily physical activity was assessed by accelerometers for 4 days. Results Total body fat expressed as a percentage of body mass was inversely

Experimental results are presented concerning tension perpendicular to grain in glulam sections where internal stresses induced by climate changes are present. The results reveal that moisture induced internal stresses may affect the tension capacity both in a positive and a negative way compared to reference specimens, free from moisture gradients. The tension capacity is reduced during moistenin

The recent article by de Souza, Lorenzini and Rizzatti J. A. V. de Souza, F. Lorenzini, and M. R. Rizatti, J. Appl. Phys. 104, 034701 2008 in this journal needs corrections and clarifications on several points. The model used by them is not suitable for the study of erythema. © 2009 American Institute of Physics. DOI: 10.1063/1.3124649

The aim of this study was to investigate the involvement of calmodulin in phospholipase D activation in SH-SY5Y cells. Cells prelabelled with [3H]-palmitic acid were incubated with calmodulin antagonists and/or other compounds. Phosphatidylethanol, a specific marker for phospholipase D activity, and phosphatidic acid were analysed. The calmodulin antagonists, calmidazolium and trifluoperazine, ind

In order to produce CO2 for stable isotope analyses (delta(18)O and delta(13)C), carbonate samples are commonly digested in phosphoric acid. The acid recipe here presented is based on phase shifting crystalline orthophosphoric acid of pro-analysis quality to a liquid state through heating, followed by pre-vacuum treatment during a start-up procedure before mass analyses for common acid bath prepar

It is important to compare different contrast media used in bone cement according to their ability to attenuate X-rays and thereby produce image contrast between bone cement and its surroundings in clinical applications. The radiopacity of bone cement is often evaluated by making radiographs of cement in air at an X-ray tube voltage of 40 kV. We have developed a method for ranking contrast media i

This study investigated the feasibility and effects of organ bath to be used for detection of bronchial function of non-heart-beating donor (NHBD) lung after 1-h warm ischemia. Sixteen Swedish pigs were divided into two groups randomly: heart-beating donor (HBD) group and NHBD with 1-h warm ischemia (NHBD-1 h) group. The bronchial rings whose lengths and inner diameters were both 1.5 mm were obtai

Adult patients with acute lymphoblastic leukaemia ( ALL) have been treated according to national protocols in Sweden since 1986. Stem cell transplantation (SCT) has been recommended in first remission for patients with risk factors for relapse, and for standard risk patients only after relapse. In this retrospective study, the results of autologous and allogeneic SCT in these populations were eval

Human calbindin D-28k is a Ca2+ binding protein that has been implicated in the protection of cells against apoptosis. In this study, the structural and functional significance of the five cysteine residues present in this protein have been investigated through a series of cystein e-to-serine mutations. The mutants were studied under relevant physiological redox potentials in which conformational

A second species of the hitherto monotypic genus Microdonophagus Schauff is described as Microdonophagus levis sp. nov. The species is described from material collected at La Selva Biological Research Station in Costa Rica. Unlike the previously described species, Microdonophagus woodleyi Schauff, it is described from females only and the biology is not known. The addition of a second species of M

We recently finemapped a type 1 diabetes (T1D)-linked region on chromosome 21, indicating that one or more T1D-linked genes exist in this region with 33 annotated genes. In the current study, we have taken a novel approach using transcriptional profiling in predicting and prioritizing the most likely candidate genes influencing beta-cell function in this region. Two array-based approaches were use

Phosphoinositides (PIs) constitute a minor fraction of total cellular lipids in all eukaryotic cells. They fulfill many important functions through interaction with a wide range of cellular proteins. Members of distinct inositol lipid kinase families catalyze the synthesis of these phospholipids from phosphatidylinositol. The hydrolysis of PIs involves phosphatases and isoforms of PI-specific phos

Effects of annual variation in rainfall, temperature and humidity on flowering abundance of eight temperate woodland plants (Anemone nemorosa, Cardamine bulbifera, Lamiastrum galeobdolon,Oxalis acetosella , Ranunculus ficaria, Stellaria holostea, Viola reichenbachiana and Viola riviniana) were studied during 12 consecutive years (1989–2000) in a hornbeam (Carpinus betulus) forest in southeast Swed