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Purpose: Violence against women is a major public health concern. Comparative research on outcomes across different service providers remains limited. Method: Women seeking support from social welfare units or women’s shelters were recruited from six organizations in Sweden. A pre–post design was applied, with structured interviews and questionnaires at baseline and 1-year follow-up. Fifty-one womViolence against women is a major public health concern. Comparative research on outcomes across different service providers remains limited. Method: Women seeking support from social welfare units or women's shelters were recruited from six organizations in Sweden. A pre–post design was applied, with structured interviews and questionnaires at baseline and 1-year follow-up. Fifty-one women partic

Background: Sport-related concussion (SRC) is a common and complex injury in athletic populations. Linear head acceleration (LHA) and rotational head acceleration (RHA) are key biomechanical factors believed to contribute to SRC, each through distinct mechanisms. Evaluating head impact magnitudes across different sports, athlete populations, and measurement methods is essential for advancing SRC

How do actors overlook uncomfortable information? We add to the understanding of how potential problems can be ignored over long periods, in spite of recurrent warnings. Ignoring then becomes a dynamic process of responding to evolving ignoring ‘threats’ or triggers by combining knowledge-seeking and knowledge avoidance in ways that must be continuously legitimated, both in one’s own eyes and in t

Serglycin (SRGN) has been found overexpressed and secreted in glioblastoma (GBM), associated with tumorigenic signaling and poor prognosis. In this study, we aimed to elucidate the involvement of SRGN in the unfolded protein response (UPR), an oncogenic signaling pathway implicated in protein recycling and cell fate. Herein, we developed stably transduced LN-18shSCR GBM cells, expressing high leve

As populations age, many countries are raising retirement ages and encouraging longer working lives. In Sweden, where old-age employment rates are already high, questions remain about how these patterns vary across regions and labour market segments. This article provides a comprehensive overview of old-age employment trends from 1990 to 2021, using detailed population register data. While employm

Direct reprogramming offers a powerful approach to generate therapeutic cell types, but progress is limited by an incomplete understanding of transcription factor (TF) cooperativity. Here, we present a protocol for performing combinatorial TF screening to resolve reprogramming factor networks that drive cell identity. We describe steps for arrayed lentiviral production, transduction, and reprogram

In October 2023, storm Babet led to the most severe erosion in decades along the Swedish South coast. In this study we approach the affected coastal landscape as a coupled social-ecological system where environmental components (e.g. geology, bathymetry, waves) interact with social components (e.g. infrastructure, management, economic activities) to influence the outcome of an extreme event. We us

Neurofilament light chain (NfL) is a promising biomarker of axonal injury across acute and chronic neurodegeneration, which can improve drug discovery and disease monitoring models. Traditional in vivo animal models cannot fully mimic human pathophysiology of neurodegenerative diseases (NDDs), but in vitro models based on human cells solve this problem, reducing the time and cost of drug testing.

Time-resolved imaging of plasmonic near fields is well-established at visible wavelengths but remains largely unexplored in the short-wavelength infrared (SWIR) range. Here, we use time-resolved photoemission electron microscopy (TR-PEEM) to directly visualize ultrafast plasmon dynamics in silver nanowires driven by a few-cycle SWIR pulses. We observe strong electric-field enhancement localized at

Granulomas are organized immune aggregates of myeloid and lymphoid cells that arise when the host fails to eliminate persistent stimuli; however, their function remains paradoxical, by promoting both protection from systemic dissemination while also promoting a niche for microbial survival. Traditionally defined by histopathology and morphology, granulomas are now being revisited with high-through

Alzheimer's disease (AD) is marked by progressive cognitive decline, highlighting the importance of cognitive assessment in both clinical practice and research. This study investigates the temporal dynamics of cognitive decline and the differential sensitivity of cognitive measures across the AD spectrum. Cognitive measures, functional assessments, and amyloid-beta (Aβ) and tau positron emission t

Suggestive QTL affecting raw firmness scores and average Instron force, tenderness, juiciness, and chewiness on cooked meat were mapped to pig chromosome 2 using a three-generation intercross between Berkshire and Yorkshire pigs. Based on its function and location, the calpastatin (CAST) gene was considered to be a good candidate for the observed effects. Several missense and silent mutations were

Objectives: To investigate possible obesity candidate genes in regions of porcine quantitative trait loci (QTL) for fat deposition and obesity-related phenotypes. Research Methods and Procedures: Chromosome mapping and QTL analyses of obesity candidate genes were performed using DNA panels from a reference pig family. Statistical association analyses of these genes were performed for fat depositio

The experimental power of a granddaughter design to detect quantitative trait loci (QTL) in dairy cattle is often limited by the availability of progeny-tested sires, by the ignoring of already identified QTL in the statistical analysis, and by the application of stringent experimentwise significance levels. This study describes an experiment that addressed these points. A large granddaughter desi

The gene, acyl-CoA:diacylglycerol acyltransferase1 (DGAT1), was recently identified as the one underlying the quantitative trait locus (QTL) for milk production traits in the centromeric region of the bovine chromosome 14. Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1

A three-generation resource family was created by crossing two Berkshire grandsires with nine Yorkshire granddams to identify QTL affecting growth, body composition, and meat quality. A total of 512 F2 offspring were evaluated for 11 traits related to growth and body composition and 28 traits related to meat quality. All animals were initially genotyped for 125 markers across the genome. The objec

A joint analysis of five paternal half-sib Holstein families that were part of two different granddaughter designs (ADR- or Inra-design) was carried out for five milk production traits and somatic cell score in order to conduct a QTL confirmation study and to increase the experimental power. Data were exchanged in a coded and standardised form. The combined data set (JOINT-design) consisted of on