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INTRODUCTION: Migraine aura affects approximately one-third of migraine patients. In some individuals, aura remains highly disabling due to the lack of effective, targeted treatment options. This study evaluates the effectiveness and long-term management of lamotrigine (LTG) in a clinical Cohort specifically burdened by frequent or severe aura.METHODS: A retrospective observational study was condu
Case comment, Sweden HFD 2025 ref. 58. The Supreme Administrative Court held that statutory compensation payable where a client company declined to offer permanent employment fell within the expert tax regime, emphasizing that the decisive factor was the compensation’s link to the work performed rather than who bore its cost.
Public participation in international environmental law constitutes an evolving concept founded in sustainable development processes and crystalized by international frameworks. The 1998 Aarhus Convention and the 2018 Escazú Agreement, multilateral agreements at the intersection of human rights and the environment, have been central in making the implicit concept explicit. Aarhus demonstrates a maPublic participation in international environmental law constitutes an evolving concept founded in sustainable development processes and crystalized by international frameworks. The 1998 Aarhus Convention and the 2018 Escazú Agreement, multilateral agreements at the intersection of human rights and the environment, have been central in making the implicit concept explicit. Aarhus demonstrates a ma
PURPOSE: This study aimed to describe the current management of patients with keratoconus in European and Middle Eastern countries through the collection of real-world data from clinicians actively managing keratoconus.METHODS: Computer-assisted web interviewing survey targeting ophthalmologists actively involved in collagen cross-linking (CXL) management. The questionnaire covered clinician demog
Grain rotation under concurrent grain boundary (GB) migration can be observed in experiments, but poses a challenge in simulations. The need to resolve atom-scale structures while tracing GB migration over extended time scales defy most modeling approaches, including molecular dynamics (MD). In this work, phase field crystal (PFC) modeling is adopted as it permits the required combination of high
Research on migration in later life has predominantly focussed on retirement, amenities, and family-related relocation, while determinants of work-related migration has received comparatively little attention. Yet, rising labor force participation among older individuals makes understanding their work-related mobility increasingly important. Using longitudinal Swedish register data covering 1993–2
This paper examines how occupational restructuring within local labour markets shapes the employment opportunities of older workers. Using longitudinal Swedish register data covering workers across 69 functional local labour markets between 2017 and 2023, we show that greater occupational restructuring is associated with greater occupational narrowing among older workers. This relations
Nanoparticles (NPs) are defined as particles that have a diameter less than 100 nm. Titanium dioxide (TiO2) NPs (TiO2 NPs) have gained significant attention in recent years as a possible therapeutic agent due to their unique physiochemical properties. They include tunability of the NPs, effective dopant compatibility, biocompatibility and catalytic properties. The shape and size of the NPs also pl
Circular business models are typically designed with the intent to meet customer demands, while resolving environmental issues related to resource usage, product lifetimes and waste reduction. Yet, rebound effects might hinder their positive impacts. Through a systematic literature review of 76 articles, the rebound effects of different circular business model archetypes and suggestions for their
Generative AI writing assistants and the Large Language Models (LLMs) that power them are increasingly part of how voters gather information before elections. With growing evidence that they influence users’ opinions, it is increasingly important to understand the views and positions of these tools. To better understand these views, we examine the stances supplied by six LLMs on a variety of SwediGenerative AI writing assistants and the Large Language Models (LLMs) that power them are increasingly part of how voters gather information before elections. With growing evidence that they influence users’ opinions, it is increasingly important to understand the views and positions of these tools. To better understand these views, we examine the stances supplied by six LLMs on a variety of Swedi
A Cable-Driven Parallel Robot (CDPR) is a robot driven by a set of cables and has advantages such as large workspace and low inertia. Scholars have proposed to apply Aerial Mobile Bases (AMBs) and Ground Mobile Bases (GMBs) to a CDPR to achieve a large workspace and fully constrain the moving platform. However, trajectory tracking and obstacle avoidance for CDPR-AGMBs remain open and challenging p
A unified treatment of different types of reasoning with concepts, such as category-based induction, nonmonotonic reasoning, analogies, and generics. Psychologists and philosophers have worked on topics such as category-based induction, nonmonotonic reasoning, analogies, and generics, but these problems have largely been investigated independently. In Reasoning with Concepts, Peter Gärdenfors and
During early embryonic development, the human neural tube is formed and patterned through spatial regionalization of cell identity, driven by gene regulatory responses to morphogen gradients. However, many of the underlying mechanisms remain unclear. Here, we integrate single-cell RNA sequencing data from in vitro emulation of neural tube patterning to develop computational models of rostral-cauda
Purpose: The primary aim of this study was to describe physical fitness in a large real-world cohort of patients entering exercise-based cardiac rehabilitation (EBCR) after first-time myocardial infarction (MI). The secondary aim was to compare the results with clinical reference values. Methods: This registry-based cohort study used data from the Swedish Web-system for Enhancement and Development
Objectives To compare beta-lactam monotherapy versus clindamycin or addition of metronidazole in patients with peritonsillar abscess (PTA). Methods This population-based, retrospective cohort study compared treatment with beta-lactam monotherapy (reference) with clindamycin or addition of metronidazole in patients with PTA during 2013–2020 in the Skåne region, Sweden. The primary outcome was a com
Background: Adjunctive corticosteroid therapy appears to be beneficial for adults with severe community-acquired pneumonia (CAP), but data on Mycoplasma pneumoniae CAP are limited. This study aimed to evaluate if adjunctive betamethasone reduced time to resolution of hypoxaemia in adults hospitalised with M. pneumoniae CAP. Methods: An open-label, multicentre, randomised, controlled trial was cond
Genetic variants in the DNA polymerase enzymes POLE and POLD1 can affect protein function by altering stability, catalysis, DNA binding, and interactions with other biomolecules. Understanding the structural basis of these variants is important for a comprehensive interpretation of variant impact. In this study, we used MAVISp, a modular structure-based framework, and molecular dynamics simulation
Penile prosthesis implantation (PPI) is an effective treatment for refractory erectile dysfunction (ED), but changes in penile length after surgery remain a major determinant of patient satisfaction. We aimed to identify patient- and surgery-related factors associated with final penile length, measured as total implanted device length. We analysed prospectively collected data from the PHOENIX regi
Community energy (CE) is increasingly discussed as a democratic alternative to centralized energy systems, yet its forms and effects vary substantially across national contexts. This article compares CE developments in Germany and Sweden, two countries with ambitious climate agendas but contrasting energy-governance arrangements. The paper examines how institutional frameworks, political cultures,
Objective Large population-based studies that could identify risk factors associated with sepsis mortality are scarce, but could be helpful in clinical risk assessments. With this study, the authors aimed to examine possible risk factors for sepsis mortality. Methods The authors conducted an open nationwide cohort study, including 157,143 individuals aged ≥ 18-years diagnosed with (first event) se
