Filtyp
Strong excitation with high electromagnetic fields can generate lasing in gaseous media by resonant excitation. Previous efforts have shown that the lasing signal can be emitted perpendicular to the direction of the pump laser if the shape of the gain volume can be controlled. This paper reports on the characterization of sideways emitted lasing obtained through two-photon pumping in oxygen atoms
This paper reports the first measurement of the transverse momentum (pT) spectra of primary charged pions, kaons, (anti)protons, and unidentified particles as a function of the charged-particle flattenicity in pp collisions at s=13 TeV. Flattenicity is a novel event shape observable that is measured in the pseudorapidity intervals covered by the V0 detector, 2.8
This Letter presents a constraint on the total width of the Higgs boson (ΓH) using a combined measurement of on-shell Higgs boson production and the production of four top quarks, which involves contributions from off-shell Higgs boson-mediated processes. This method relies on the assumption that the tree-level Higgs-top Yukawa coupling strength is the same for on-shell and off-shell Higgs boson p
Background The incidence of people diagnosed with cancer is increasing worldwide, in Sweden with approximately 65 000 new cases yearly. To enhance conditions for a continued good life, high-quality, accessible and equal cancer rehabilitation is required. In 2020 the National Board of Health and Welfare (NBHW) received a government assignment to investigate the conditions for the offer of cancer re
Purpose: Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients. Experimental Design: We conducted an international retrospective cohort study of patients with TRK fusion–driven central nervous system tumors. Results: A total of 119 patients were identified. The median age at the ti
Swedish parents today raise their children in a welfare state, where childcare is both accessible and affordable, and often within dual-income households. At the same time, they have witnessed a challenged welfare state affected by cutbacks, privatizations, and the demands of an increasingly flexible working life. Previous research has shown that Swedish grandparents are more involved in their aduSwedish parents today raise their children in a welfare state, where childcare is both accessible and affordable, and often within dual-income households. At the same time, they have witnessed a challenged welfare state affected by cutbacks, privatizations, and the demands of an increasingly flexible working life. Previous research has shown that Swedish grandparents are more involved in their adu
Knee osteoarthritis is a highly prevalent whole-joint disease that is associated with substantial morbidity. If step changes are to be made in the management of knee osteoarthritis, novel patient stratification approaches are needed to identify the most effective treatment for individual patients. Numerous methods for stratifying patients with knee osteoarthritis can be employed; clinical presenta
Anthropogenic land-use and climate change pose novel selection pressures on bees, yet their evolutionary responses in terms of morphological or physiological adaptations remain unclear. While adaptive responses are expected, these may be constrained by gene flow when changes in selection pressures are spatially heterogeneous. The buff-tailed bumblebee (Bombus terrestris) is a widespread species th
Importance: Emerging evidence suggests that cholesterol plays a role in breast cancer (BC) metabolism, raising the possibility that cholesterol-lowering medications, such as statins, may improve BC prognosis. Objective: To evaluate the association between postdiagnosis statin initiation and BC mortality using an emulated target trial approach. Design, Setting, and Participants: This observational
Biologics targeting interleukin-4 receptor subunit α (IL-4Rα) and interleukin-33 (IL-33) have demonstrated clinical efficacy in asthma, highlighting the importance of IL-4, IL-13, and IL-33 in respiratory diseases. Despite this, few studies have linked preclinical models to human diseases or evaluated disease biology in clinical trials. To address these gaps, we evaluated transcriptional, cellular
The cofactor-free arylmalonate decarboxylase (AMDase) is a valuable biocatalyst for synthesizing α-aryl and α-alkenyl alkanoic acids with excellent stereoselectivity. We engineered a new hydrophobic pocket in (S)-selective AMDase mutants, creating AMDase ICPLLG with enhanced activity. For the investigation of the mechanism, we synthesized isotope-labeled, pseudochiral 2-methyl-2-vinyl malonate via
Environmental gradients affect vegetation structure and ecosystem productivity. Along the northern Australia tropical transect (NATT), which transitions from tropical moist conditions in the north to arid conditions in the south, vegetation composition and structure are closely tied to rainfall patterns. We hypothesise that biotic competition and abiotic stress exhibit opposing patterns along the
Background Suicide is more common among males and in older age, but the understanding of sex-specific and age-specific risk indicators is limited. Objective To describe the sex-specific and age-specific prevalence of 25 suicide risk indicators in the year preceding suicide and estimate their associations with suicide. Methods Register-based population-nested case-control study in Sweden, 2009–2021
We present an approach to nanoscale-resolution high-sensitivity imaging of internal material structure under in situ/operando conditions for virtually any sample environment. When bulky or heavy sample environment is required state-of-the-art X-ray imaging techniques, such as scanning and full-field microscopy or holography fail to deliver high-resolution imaging capabilities due to either i) extr
Cubosomes─colloidal dispersions of lipid inverted bicontinuous cubic phases─are promising nanosystems for advanced drug delivery applications. Here, we report on a microfluidic hydrodynamic flow-focusing approach for solvent exchange that enables the preparation of cubosomes with tunable size. The approach involves a preliminary step where the lipid phytantriol, the main building block, is first d
BACKGROUND: Prognostication of recovery in patients who are unconscious following cardiac arrest can be guided by concentrations of brain injury biomarkers in the blood. The optimal biomarker and cutoff concentrations for the prediction of outcome remain unknown. In this study, we aimed to evaluate which biomarker of brain injury is most accurate for predicting functional outcome after cardiac arr
Context. AU Mic is a very active M dwarf star with an edge-on debris disk and two known transiting sub-Neptunes with a possible third planetary companion. The two transiting planets exhibit significant transit-timing variations (TTVs) that are caused by the gravi tational interaction between the bodies in the system. Aims. Using photometrical observations taken with the CHaracterizing ExOPlanet Sa
This study examines how public transport passengers experience and use travel time and under what conditions they are particularly concerned about shorter travel time. Using a survey of Swedish public transport users and a follow-up focus group, we compare current patterns with a similar 2009 study. Findings indicate a slight decline in perceived value of travel time, coinciding with a marked redu
We report the synthesis of highly enantiopure perdeuterated poly-L-lactic acid and poly-D-lactic acid polymers with well-defined molecular weight by polymerization of perdeuterated lactides. Enantiopure D- and L-lactic acid-d4 monomers were synthesized from sodium pyruvate-d3 using D- and L-lactate dehydrogenase enzymes (D-LDH and L-LDH) as biocatalysts. The reduced form of the co-enzyme nico
