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Host-virus interactions in archaea is a topic that still remains little explored. A recent study has revealed that the protein gp21 from SIRV2 (Sulfolobus islandicus rodshaped virus 2) induces cell gigantism and growth arrest in the archaeal host Sulfolobus islandicus LAL14/1 after being overexpressed. Remarkably, homologs of this protein have been found in a wide variety of viruses infecting arch
