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OBJECTIVES: Ultra-high dose rate irradiation (UHDR) has been shown to spare normal tissue in various model systems. This study evaluates its potential to sterilize cancer cells using spheroid tumor models.METHODS: Spheroids from glioblastoma (U87), hypopharyngeal squamous cell carcinoma (two sizes, FaDusmall and FaDularge) and breast adenocarcinoma (T47D) cells were irradiated with electron beams

Deep metabarcoding offers an efficient and reproducible approach to biodiversity monitoring, but noisy data and incomplete reference databases challenge accurate diversity estimation and taxonomic annotation. Here, we introduce a novel algorithm, NEEAT, for removing spurious operational taxonomic units (OTUs) originating from nuclear-embedded mitochondrial DNA sequences (NUMTs) or sequencing error

Background/Objectives: Electroencephalography (EEG) is increasingly used in pediatric anesthesia to detect abnormal brain activity such as burst suppression (BS), a marker of profound cortical inactivation. The objective of this study was to assess anesthetic depth using bilateral spectral edge frequency (SEF) and to determine the incidence of frontal cortical BS in young children undergoing cardi

BACKGROUND AND OBJECTIVE: Virtual reality (VR) is a rapidly evolving technology that is currently utilized in hospital settings for various types of surgical procedures. The extent to which VR is evident in improving patient outcomes is unknown. This systematic review assesses the impact of VR on adult patients undergoing elective surgical procedures.DATABASES AND DATA TREATMENT: The following dat

Background Long-term pathological breathlessness is a life-limiting symptom that risks taking control of the individual’s life. We aimed to evaluate how locus of control (LOC), an individual’s perceived control of present and past life events, relates to breathlessness in a middle-aged general population. Methods A population-based, cross-sectional analysis of people aged 50–64 years was conducted

Scale invariance is a ubiquitous observation in the dynamics of large distributed complex systems. The computation of its scaling exponents, which provide clues on its origin, is often hampered by the limited available sampling data, making an appropriate mathematical description a challenge. This work investigates the behavior of correlation functions in fractal systems under conditions of severe

This commentary discusses the role of increasingly artificial intelligence-infused big tech platforms in facilitating and normalising high-emission lifestyles and consumption practices. It introduces the notion of algorithmically facilitated emissions to initiate a shift from a logic of ‘climate collapse by design’ to a logic of ‘emissions reduction by design’. Reducing consumption-based emissions

Investigating respiratory fluxes is decisive for understanding the complex interplay between metabolic processes. Studies of cells and tissues with limited sample availability and low respiratory rates may benefit from small experimental volumes. We examined if the 0.5-mL chamber yields results consistent with the 2.0-mL chamber at identical sample concentrations used in high-resolution respiromet

SUMMARY: Craniopharyngiomas (CPs) are rare brain epithelial tumours arising in the suprasellar region, infiltrating adjacent areas causing visual loss, panhypopituitarism, cognitive deficits and morbid obesity. Papillary CPs (PCPs) harbour in 94% BRAF mutation cases. Two patients with PCP and BRAF V600E mutations but with different tumour status were treated with BRAF and MEK inhibitors. Case I wa

The rise of livestreaming as a promotional tool has increasingly attracted scholars to focus on the impact of livestreaming on tourism destination marketing and tourists' psychology, including perception. This study examines the effect of informativeness and interactivity on tourist flow, inspiration, and travel intention in travel livestreaming. Through 344 valid survey-based data, this study emp

Partnervåld utgör ett allvarligt samhällsproblem med omfattande konsekvenser för både individer och samhälle. För att minska risken för skada till följd av problemet behöver socialtjänsten arbeta med både primär och sekundär prevention. Ett effektivt förebyggande arbete förutsätter emellertid kunskap om den tidsmässiga ordningen och variationen av riskfaktorer som är förknippade med utövande av paIntimate partner violence (IPV) is a serious social issue with profound consequences for individuals and society. To reduce the risk of harm caused by IPV perpetration, social services need to engage in both primary and secondary prevention efforts targeting the issue. However, effective preventive work requires knowledge about the temporal sequence and variability of risk factors associated with

The consideration of patient experiences has gained significant attention in recent years as part of the broader shift toward patient-centered care. The aim of this chapter is to explore the personal experiences of individuals before and after lung transplantation, highlighting how these experiences are deeply embedded within a network of family and social connections. This chapter emphasizes the

Protein deletions are frequent among both natural and pathogenic variations. Many of them are misclassified in variation databases and the literature. Nonsense-mediated decay prevents the expression of many nucleotide deletions. Many variants classified as protein deletions are not expressed at all. We conducted an exhaustive systematic analysis of three types of deletions: N- and C-terminal delet

BackgroundWhile physical activity is known to affect the risk of MAFLD in adults, evidence in adolescents is limited and often based on self-reported questionnaires. We therefore used wearable device–based measurements to investigate the association between physical activity and MAFLD in adolescents.MethodsData were obtained from the National Health and Nutrition Examination Survey (NHANES) databa

Background: Although optical coherence tomography (OCT) has become essential in pediatric ophthalmology, normative data for children are lacking in most device databases. Due to ongoing ocular growth and developmental changes that occur during childhood and adolescence, adult reference values are not appropriate for pediatric use. Additionally, OCT measurements vary across devices, indicating the

This chapter introduces systematic reviews and provides a summary of systematic review methods. Because of the challenges in palliative care trials, systematic reviews might be even more relevant in palliative care than in many other areas of health care. This chapter highlights the reasons why a researcher should use a systematic review, as well as the instances when systematic reviews are not an