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We measured 135 cross sections of residual nuclei produced in fragmentation reactions of 12C, 14N, and 13−16,20,22O projectiles impinging on a carbon target at kinetic energies of near 400A MeV, most of them for the first time, with the R 3 B/LAND setup at the GSI facility in Darmstadt (Germany). The use of this state-of-the-art experimental setup in combination with the inverse kinematics techniq
This article analyses the role that ‘ordre public’ and morality exceptions can play in the granting of patents on inventions in the field of human germline editing and the consequences of this policy option. In order to provide the context for such an analysis, the article will, first, provide an overview of the current patent landscape for relevant genome editing technologies, drawing attention t
Crystallography is an invaluable tool in materials science, solid state physics and protein science. Understanding crystallography requires grasping the powerful but abstract concept of reciprocal space. Here a simple but insightful experiment using a laser pointer and Au microdisc arrays to explore and illustrate Bragg diffraction and reciprocal space is demonstrated. The Au microdisc arrays were
The Cenozoic Himalaya-Tibet orogen is generally regarded as the archetypal continental collision zone and is often used as an analogue for interpreting ancient orogenic events. However, given the wide diversity observed in present-day collisional mountain belts, the extent to which such inferences can be made remains debated. In this Review, we compare the metamorphic and magmatic record of the Hi
Selenium has been suggested to be protective regarding breast cancer risk but no overall effect has been established. Genetics may modify the effect. This study compares the effect of selenium exposure on breast cancer risk between women with different alleles in single-nucleotide polymorphisms (SNPs). The Malmö Cancer and Diet Study, a cohort including 17,035 women and >25 years of follow-up on b
En analys av alla större imperiers undergång från forntiden till idag, med målet att urskilja gemensamma mönster i utvecklingen.
Policymakers and scientists are paying increasing attention to how social norms can promote pro-environmental behaviour and sustainable energy use. We contribute to this field by experimenting with and assessing the impacts of social norms on low-carbon mobility options. Taking Sweden as a case study, we develop two complementary randomised controlled experiments to: 1) analyse the role of social
We report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1, LCDR3 and HCDR2. Both paratopes can be independently selected and combined into the desired bispecifWe report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1, LCDR3 and HCDR2. Both paratopes can be independently selected and combined into the desired bispecif
När skottskogsbruket/stubbskottsängsbruket upphörde i början av 1800-talet försvann även landskapet som humlesugan, Betonica officinalis L., var anpassad till. Från att ha varit allmän på sydvästra Lolland och i västra Mellanskåne blev den mycket sällsynt inom dessa kärnområden i humlesugans tidigare utbred- ning i Skandinavien. Ändå lyckades den överleva på sju lokaler. För att bevara dessa krävsWhen coppice forestry and the use of wooded meadows ceased in the early 19th century, the landscape to which Betony, Betonica officinalis L., was adapted also disappeared. From being common in southwestern Lolland and in western MidSkåne, it became very rare in these core areas of Betony’s earlier distribution in Scandi navia. However, the species has managed to survive at seven localities and t
OBJECTIVE: FLASH irradiation reportedly produces less normal tissue toxicity, while maintaining tumour response. To investigate oxygen's role in the 'FLASH effect', we assessed DNA damage levels following irradiation at different oxygen tensions, doses and dose rates.METHODS: Samples of whole blood were irradiated (20 Gy) at various oxygen tensions (0.25-21%) with 6 MeV electrons at dose rates of
Introduction. According to the 2021 ERC/ESICM guideline recommen-dations, elevated neuron-specific enolase [NSE] levels as well as diffuseand extensive anoxic damage on neuroimaging are predictors of poorneurological outcome after cardiac arrest.(1) We previously describedthat NSE is elevated in patients with generalised oedema on com-puted tomography [CT]. (2).Objectives. In this study, we aim to
The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is a dual-hemisphere, near-infrared (NIR), spectroscopic survey with the goal of producing a chemodynamical mapping of the Milky Way. The targeting for APOGEE-2 is complex and has evolved with time. In this paper, we present the updates and additions to the initial targeting strategy for APOGEE-2N presented in Zasowski et al.
While wealth-holding patterns in rural areas have been well studied, the link between initial conditions, prospects for wealth accumulation, and the persistence of inequality at an agricultural frontier is less clear. On the one hand, the frontier is thought to have had a levelling effect, with the availability of cheap land acting as an equalizer. On the other hand, land rents, accumulated during
Background: Essential proteins play an important role in the process of life, which can be identified by experimental methods and computational approaches. Experimental approaches to identify essential proteins are of high accuracy but with the limitation of time and resource-consuming. Objective: Herein, we present a computational model (PEPRF) to identify essential proteins based on machine lear
