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High-throughput sequencing of the adaptive immune receptor repertoire (AIRR-seq) is providing unprecedented insights into the immune response to disease and into the development of immune disorders. The accurate interpretation of AIRR-seq data depends on the existence of comprehensive germline gene reference sets. Current sets are known to be incomplete and unrepresentative of the degree of polymo
Introduction. When using bibliometrics for research evaluation, the classification of research fields is an issue of great importance. The purpose of this paper is to outline a brief theoretical framework for analysing the role of classification in research evaluation practices.Theory. Taking departure in the concept of ‘boundary objects’ we develop a theoretical framework for analyses of how scie
Recension av doktorsavhandling om dansk konst från 1800-talets första hälft.
Recension av avhandling i konstvetenskap.
Recension av översiktsverk om dansk konst 1750-1850.
The development of new ultrasound imaging technologies that aim to resolve objects smaller than the conventional ultrasounds diffraction limit calls for new types of phantoms to evaluate these technologies. When it comes to vascular flow phantoms, this becomes challenging due to the difficulty of manufacturing phantoms with vessels smaller than 1 mm in diameter. Here we describe a novel manufactur
This paper presents a preliminary method developed for improved decision-support based on probabilistic methods for risk assessment using building performance simulations. The aim of the method is to support the decision-maker in all stages of the building process when deciding on the design of a building by including uncertainties and quantifying; the probability of fulfilling objectives; energy
As observed in earlier studies, there is evidently a performance gap between the predicted annual energy use from building performance simulations basedon traditional deterministic methods compared to the monitored annual energy use of a building. The hypothesis is that using a probabilistic method makes it possible to consider the uncertainties in the input data and quantify the overall uncertainAs observed in earlier studies, there is evidently a performance gap between the predicted annual energy use from building performance simulations based on traditional deterministic methods compared to the monitored annual energy use of a building. The hypothesis is that using a probabilistic method makes it possible to consider the uncertainties in the input data and quantify the overall uncertai
Many countries strive for continued reductions in energy demand from new buildings as a way of mitigating the impact of climate change. Consequently, the importance of accurate and efficient building performance simulations (BPS) increases to improve the prediction in energy demand during the design-process for buildings. As observed in earlier studies, there is currently a performance gap between
A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with pot
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cance
Magnetomotive ultrasound, MMUS, can reveal the presence of a magnetic contrast agent by applying an external magnetic field. If the interaction between the agent and the field is strong enough, a movement that can be detected by ultrasound is induced in the surrounding tissue, thereby inferring the contrast agent distribution. Electromagnets have been used to generate the necessary magnetic field,
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We te
