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Registry-based medical research is an important tool in assessing health care interventions in the general population. Observational studies are used to establish effectiveness whereas randomized clinical trials assess efficacy in an experimental manner targeting a carefully selected population of patients. Medical registries may be office or hospital based, state/provincial, national, or more rec

https://www.lupop.lu.se/article/registry-based-medical-research-data-dredging-or-value-building-quality-care - 2025-12-20

Clinical auditing is an emerging instrument for quality assessment and improvement.Moreover, clinical registries facilitate medical research as they provide ‘real world’ data. It is importantthat entered data are robust and reliable. The aim of this study was to describe the evolving procedureand results of data verication within the Dutch Institute for Clinical Auditing (DICA). New publication i

https://www.lupop.lu.se/article/data-verification-nationwide-clinical-quality-registries - 2025-12-20

Liver cirrhosis is a risk factor for hepatocellular carcinoma (HCC). While the HCC risk is thought to be highest in hepatitis B and hepatitis C, the risk in other cirrhosis etiologies is not fully established. Therefore, we aimed to study the risk and outcome of HCC in alcoholic cirrhosis compared to cirrhosis of other etiologies, in Sweden. New publication in Scandinavian Journal of Gastroenterol

https://www.lupop.lu.se/article/risk-and-outcome-hepatocellular-carcinoma-liver-cirrhosis-southern-sweden-population-based-study - 2025-12-20

Want research in Europe to be more FAIR? Your views count! FAIRsFAIR Open Consultation is open. Read more here.

https://www.lupop.lu.se/article/fair-data-policies-and-practices - 2025-12-20

The conference theme, “Data by Design: Building a Sustainable Data Culture”, emphasizes two core values embedded in the culture of Gothenburg and Sweden: design and sustainability. Read more here.

https://www.lupop.lu.se/article/46th-annual-iassist-conference-gothenburg - 2025-12-20

Under seminariet presenterades den andra, kvantitativa, delstudien av forskares attityder till forskningskommunikation och öppen vetenskap. Studien bygger på enkätsvar från cirka 3 700 forskare vid svenska lärosäten. Se en inspelning av seminariet här.

https://www.lupop.lu.se/article/dialogseminarium-om-forskare-och-kommunikation - 2025-12-20

Selection bias affects Mendelian randomization investigations when selection into the study sample depends on a collider between the genetic variant and confounders of the risk factor–outcome association. However, the relative importance of selection bias for Mendelian randomization compared with other potential biases is unclear. New publication in International Journal of Epidemiology.Read more

https://www.lupop.lu.se/article/contextualizing-selection-bias-mendelian-randomization-how-bad-it-likely-be - 2025-12-20

Cross-sectional normative dual energy X-ray absorptiometry data in 1052 men aged 18–28 years New publication in BMC Musculoskeletal Disorders.Read more here.

https://www.lupop.lu.se/article/does-peak-bone-mass-correlate-peak-bone-strength - 2025-12-20

The European Medicines Agency (EMA) established the Patient Registry Initiative to explore ways of supporting the use of patient registries in generating high-quality data for regulatory decision making and to enable a systematic approach to their use. We review barriers and opportunities for using patient registries in medicines regulation. A key aspect is that early discussions between all parti

https://www.lupop.lu.se/article/barriers-and-opportunities-use-patient-registries-medicines-regulation - 2025-12-20

Soil-transmitted helminth infections have been found to be associated with child development. The objective was to investigate hemoglobin levels and malnutrition as mediators of the association between Ascaris infection and intelligence quotient (IQ) scores in children. New publication in Epidemiology.Read more here.

https://www.lupop.lu.se/article/bayesian-methods-exposure-misclassification-adjustment-mediation-analysis - 2025-12-20

Establishment of orthopaedic registers started in 1975 and many registers have been initiated since. The main purpose of registers is to collect information on patients, implants and procedures in order to monitor and improve the outcome of the specific procedure. New publicatoin in Efort.Read more here

https://www.lupop.lu.se/article/what-when-and-how-orthopaedic-registers-introduction-register-based-research-0 - 2025-12-20

Did you know that you can find papers on the quality of and uses for the Swedish National Patient Register on lupop.lu.se? To read more, go here.

https://www.lupop.lu.se/article/validating-swedish-national-patient-register - 2025-12-20

The Research Symbiont Awards, given annually, recognize exemplars in the practice of data sharing. Read more here.

https://www.lupop.lu.se/article/research-symbiont-awards - 2025-12-20

The Chinese National Twin Registry (CNTR) currently includes data from 61 566 twin pair from 11 provinces or cities in China. Of these, 31 705, 15 060 and 13 531 pairs are monozygotic, same‐sex dizygotic and opposite‐sex dizygotic pairs, respectively, determined by opposite sex or intrapair similarity. Read more here.

https://www.lupop.lu.se/article/chinese-national-twin-registry-gold-mine-scientific-research - 2025-12-20

Application to epidemiological record data in a large-scale biobank (Tohoku Medical Megabank Organization, Japan) shows that a combination of kurPCA and RAMP effectively detects known errors or inconsistent patterns. Read more here.

https://www.lupop.lu.se/article/outlier-detection-questionnaire-data-biobanks - 2025-12-20

Socioeconomic status has a negative impact on swimming ability in Swedish children, a new BlueHealth study has found. Read more here.

https://www.lupop.lu.se/article/new-study-highlights-disparity-swimming-skills - 2025-12-20

A pan-European enterprise to provide a catalogue (https://bio.tools) of tools and databases that can be used in these workflows. bio.tools not only lists where to find resources, but also provides a wide variety of practical information. Read more here.

https://www.lupop.lu.se/article/biotools-registry-software-tools-and-data-resources-life-sciences - 2025-12-20

This Glossary, rooted primarily in the Canadian context but drawing on lessons from elsewhere, describes environmental public health regulatory practice in relation to health equity, including approaches that practitioners can use to contribute to addressing the social determinants of health. Read more here.

https://www.lupop.lu.se/article/glossary-health-equity-context-environmental-public-health-practice - 2025-12-20

Mediation analysis is a powerful tool for understanding mechanisms, but conclusions about direct and indirect effects will be invalid if there is unmeasured confounding of the mediator–outcome relationship. Read more here.

https://www.lupop.lu.se/article/approximate-sensitivity-analysis-unmeasured-mediator-outcome-confounding - 2025-12-20

Over the past decade, several large registries of patients with idiopathic pulmonary fibrosis (IPF) have been established. These registries are collecting a wealth of longitudinal data on thousands of patients with this rare disease. The data collected in these registries will be complementary to data collected in clinical trials because the patient populations studied in registries have a broader

https://www.lupop.lu.se/article/patient-registries-idiopathic-pulmonary-fibrosis - 2025-12-20