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Although colorectal cancer (CRC) screening guidelines acknowledge the need for earlier screening for high-risk individuals, such as those with family history of CRC, there is limited information on how many years earlier these high-risk individuals should be screened; current practice is based on weak evidence. We aimed to provide risk-adapted recommendations on the starting age of CRC screening f

https://www.lupop.lu.se/article/calculating-starting-age-screening-relatives-patients-colorectal-cancer-based-data-large-nationwide - 2025-12-21

Prenatal exposures may contribute to male infertility in adult life, but large-scale epidemiological evidence is still lacking. The Fetal Programming of Semen quality (FEPOS) cohort was founded to provide means to examine if fetal exposures can interfere with fetal reproductive development and ultimately lead to reduced semen quality and reproductive hormone imbalances in young adult men. Read mor

https://www.lupop.lu.se/article/fetal-programming-semen-quality-fepos-cohort-dnbc-male-offspring-cohort - 2025-12-21

We included adults aged 18 years and older in Sweden in first‐generation (n = 6 042 891) and second‐generation (n = 4 860 469) sub‐studies. MS was defined via two diagnoses in the Swedish National Patient Register. MS risk was estimated by Cox regression, with hazard ratios (HRs) and 95% confidence intervals (CI), in different immigrant groups, using Swedish‐born as referents in first‐generation s

https://www.lupop.lu.se/article/multiple-sclerosis-among-first-and-second-generation-immigrant-groups-sweden - 2025-12-21

While discontinuation of COPD maintenance medication is a known problem, the proportion of patients with discontinuation and its geographical and sociodemographic distribution are so far unknown in Sweden. Therefore, we analyse this question by applying an innovative approach called multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Read more at https://www.dovep

https://www.lupop.lu.se/article/geographical-and-sociodemographic-differences-discontinuation-medication-chronic-obstructive - 2025-12-21

During the last 4 decades, registration of patients with primary immunodeficiencies (PID) has played an essential role in different aspects of these diseases worldwide including epidemiological indexes, policymaking, quality controls of care/life, facilitation of genetic studies and clinical trials as well as improving our understanding about the natural history of the disease and the immune syste

https://www.lupop.lu.se/article/global-systematic-review-primary-immunodeficiency-registries - 2025-12-21

Research Services is pleased to announce a pair of webinars on research funding from some of the biggest funders in Sweden. These webinars will give you a chance to hear straight from the funders about their schemes and funding philosophy, and they will also answer your questions directly. The webinars are open to all researchers at Lund, and no prior knowledge of the funders or their schemes is r

https://www.lupop.lu.se/article/research-services-presents-meet-funders - 2025-12-21

Oesophagogastric cancers carry a high mortality, economic burden and rising incidence. There is a need to monitor and improve care for this disease. Pathologic information is a cornerstone of cancer diagnosis, treatment and prognosis. Few population-based studies combine pathology information and clinical outcomes. The objective of this study is to develop a clinical and pathological database of o

https://www.lupop.lu.se/article/population-registry-esophageal-and-stomach-tumours-ontario-presto-protocol-multicentre-clinical-and - 2025-12-21

Read more at https://moh-it.pure.elsevier.com/en/publications/the-italian-registry-for-primary-immunodeficiencies-italian-prima-2

https://www.lupop.lu.se/article/italian-registry-primary-immunodeficiencies-italian-primary-immunodeficiency-network-ipinet-twenty - 2025-12-21

Alpha-1 antitrypsin deficiency (AATD) is a rare and underdiagnosed disease that is associated with the development of liver disease in adults and children and pulmonary emphysema in adults. Several studies have shown that there is limited knowledge about the disease and its diagnosis among health care providers, and there is an important inequity in the access to specialized care and appropriate t

https://www.lupop.lu.se/article/importance-reference-centers-and-registries-rare-diseases-example-alpha-1-antitrypsin-deficiency - 2025-12-21

This study exploits policy reforms in Swedish primary care to examine the effect of pay-for-performance (P4P) on compliance with hypertension drug guidelines among public and private health care providers. Using provider-level outcome data for 2005–2013 from the Swedish Prescription Register, providers in regions using P4P were compared to providers in other regions in a difference-in-differences

https://www.lupop.lu.se/article/effects-pay-performance-prescription-hypertension-drugs-among-public-and-private-primary-care - 2025-12-21

Congenitally corrected and surgical atrial redirected transposition of the great arteries (TGA) represents states where the morphological right ventricle serves as a systemic ventricle (S-RV). The S-RV is prone to failure, but data on medical treatment on this problem is limited. The purpose of this study was to evaluate the survival in adults with S-RV, with or without heart failure treatment. De

https://www.lupop.lu.se/article/effect-medical-treatment-patients-systemic-right-ventricle - 2025-12-21

Diabetes mellitus (DM) and colorectal cancer (CRC) share some risk factors, including lifestyle and metabolic disturbances. We aimed to provide in-depth information on the association of CRC risk, especially early-onset CRC, with DM, family history of CRC, and age at DM diagnosis. Read more at https://journals.lww.com/ajg/Fulltext/2020/07000/Personal_History_of_Diabetes_as_Important_as.24.aspx

https://www.lupop.lu.se/article/personal-history-diabetes-important-family-history-colorectal-cancer-risk-colorectal-cancer - 2025-12-21

People with Parkinson’s disease (PD) have lower life satisfaction (LS) than healthy peers. No study has yet identified predictors of LS in people with PD. Such information would be valuable for health care and future interventions that aim to maintain or increase LS. Read more at https://www.hindawi.com/journals/pd/2020/1561037/

https://www.lupop.lu.se/article/prediction-life-satisfaction-people-parkinsons-disease - 2025-12-21

Eight new calls for proposal are now open The Swedish Research Council has now opened several calls for proposals within Natural and engineering sciences, Educational sciences and Development research. Most of the calls are open until 10 April, but the Network grant within Educational Sciences is open until 27 March.Read more at www.vr.se.

https://www.lupop.lu.se/article/new-calls-proposal-vr - 2025-12-21

Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but based on previous randomized controlled trials and observational studies, there are still uncertainties about the safety in giving low-grade RBC transfusions to patients with sepsis. Read mo

https://www.lupop.lu.se/article/mortality-and-morbidity-low-grade-red-blood-cell-transfusions-septic-patients-propensity-score - 2025-12-21

Data from the Swedish National Registry for Pancreatic and Periampullary Cancer for all patients undergoing a PD from 2010 until 30th June 2018 were collected. The material was analysed in two groups, no POPF and clinically relevant (grade B and C) POPF. Read more at https://link.springer.com/article/10.1007/s00268-020-05735-4

https://www.lupop.lu.se/article/predictive-factors-postoperative-pancreatic-fistula-swedish-nationwide-register-based-study - 2025-12-21

Cold sensitivity is common following nerve injuries in the upper extremity, but is less well studied in carpal tunnel syndrome (CTS). We investigated cold sensitivity in CTS and its effects on surgical outcome. A search of the Swedish National Registry for Hand Surgery (HAKIR) for open carpal tunnel releases (OCTR) from 2010–2016 identified 10,746 cases. Symptom severity questionnaires (HQ-8; HAKI

https://www.lupop.lu.se/article/occurrence-cold-sensitivity-carpal-tunnel-syndrome-and-its-effects-surgical-outcome-following-open - 2025-12-21

Two hundred and eighty‐one patients hospitalized for HF (mean age, 74 years; 32% women) were assessed using cognitive tests: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive speed, Trail Making Test A, and Symbol Digit Modalities Test. The mean follow‐up time censored at rehospitalization or death was 13 months (interquartile range, 14) and 28 months (interquartile range, 29), respe

https://www.lupop.lu.se/article/cognitive-test-results-are-associated-mortality-and-rehospitalization-heart-failure-swedish - 2025-12-21

Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Read more at https://journals.sagep

https://www.lupop.lu.se/article/disentangling-social-genetic-rearing-environment-effects-alcohol-use-disorder-using-swedish-national - 2025-12-21

Adult-onset growth hormone deficiency (AGHD) is usually the last deficiency to be substituted in hypopituitarism. In children with documented GH deficiency, treatment without delay is crucial for achieving optimal effects on growth and development. In adults, it is not known whether a delay in treatment initiation influences biochemical response and the favourable physiological effects resulting f

https://www.lupop.lu.se/article/early-versus-late-initiation-gh-replacement-adult-onset-hypopituitarism - 2025-12-21