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Parametric-Regression–Based Causal Mediation Analysis of Binary Outcomes and Binary Mediators: Moving Beyond the Rareness or Commonness of the Outcome

Photo: Pixabay / Gerd Altmann In the causal mediation framework, several parametric-regression–based approaches have been introduced in the last decade for estimating natural direct and indirect effects. For a binary outcome, a number of proposed estimators use a logistic model and rely on specific assumptions or approximations that may be delicate or not easy to verify in practice. Read the paper

https://www.lupop.lu.se/article/parametric-regression-based-causal-mediation-analysis-binary-outcomes-and-binary-mediators-moving - 2025-08-29

Acceptability of patient reported outcome measures (PROMs) in a cystic fibrosis data registry

Foto från snd.gu.se Improvements in the treatment of cystic fibrosis (CF) have resulted in longer survival and an increased focus on optimising daily functioning with the condition. Patient- reported outcome measures (PROMs) are valuable tools in evaluating the health- related quality of life of persons with chronic diseases. Read the paper at https://bmjopenrespres.bmj.com/content/bmjresp/8/1/e00

https://www.lupop.lu.se/article/acceptability-patient-reported-outcome-measures-proms-cystic-fibrosis-data-registry - 2025-08-29

Methodical considerations on adjusting for Charlson Comorbidity Index in epidemiological studies

Photo: Pixabay / Arek Socha Confounding by comorbidities is of concern in many epidemiological studies. To take this into account a common strategy is to calculate each participant’s Charlson Comorbidity Index (CCI) and use this for adjustment in regression analyses. Various CCI adjustment strategies are possible, and it is unclear, which is preferable. Read the paper at https://link.springer.com/

https://www.lupop.lu.se/article/methodical-considerations-adjusting-charlson-comorbidity-index-epidemiological-studies - 2025-08-29

The use of negative control outcomes in Mendelian randomization to detect potential population stratification

A key assumption of Mendelian randomization (MR) analysis is that there is no association between the genetic variants used as instruments and the outcome other than through the exposure of interest. One way in which this assumption can be violated is through population stratification, which can introduce confounding of the relationship between the genetic variants and the outcome and so induce an

https://www.lupop.lu.se/article/use-negative-control-outcomes-mendelian-randomization-detect-potential-population-stratification - 2025-08-29

Rounding up the usual suspects: confirmation bias in epidemiological research

Photo: Pixabay / Alexander Lesnitsky Investigators performing epidemiological research frequently form hypotheses based on data availability. One might ask how it could be otherwise. After all, what is the point of forming hypotheses if they can’t be tested? Read the paper at https://academic.oup.com/ije/article/50/4/1053/6259481

https://www.lupop.lu.se/article/rounding-usual-suspects-confirmation-bias-epidemiological-research - 2025-08-29

SWE-REG Autumn Meeting 2021: How to conduct successful interdisciplinary research

The Swedish Network for Register-Based Research (SWE-REG) is a collaboration between eight research nodes – seven research environments and a graduate school in register-based research. The network strives to use register-based data for research that may benefit people’s health and well-being. Read more, and register at https://swe-reg.se/

https://www.lupop.lu.se/article/swe-reg-autumn-meeting-2021-how-conduct-successful-interdisciplinary-research - 2025-08-29

Job opportunity: Doctoral student in Medical Science - Environmental risk factors for IBD

Project title: Early-life environmental risk factors for inflammatory bowel disease: A Nordic birth cohort study Project: Inflammatory bowel disease (IBD) is a chronic, debilitating immune-mediated disease with a typical onset in childhood and young adulthood. After a rising incidence over the past decades, it now affects 0.5% of Western populations, and is an emerging disease globally. There is a

https://www.lupop.lu.se/article/job-opportunity-doctoral-student-medical-science-environmental-risk-factors-ibd - 2025-08-29

New LU-policy for open access

Open access (OA) means that research results are published freely available to everyone on the web. The university's open access policy is a way of contributing to open access being the norm for research information. There are several ways for researchers to make publications freely available. Read more at https://www.ub.lu.se/en/publish/open-access

https://www.lupop.lu.se/article/new-lu-policy-open-access - 2025-08-29

Vetenskapsrådets samordningsuppdrag om öppen tillgång till forskningsdata – delredovisning

Vetenskapsrådet har i uppdrag av regeringen att främja och samordna det nationella arbetet med att införa öppen tillgång till forskningsdata. Denna rapport är en delredovisning av Vetenskapsrådets uppdrag och beskriver arbetet och insatserna som genomförts, samt ger en internationell utblick. Ladda ner rapporten på https://www.vr.se/analys/rapporter/vara-rapporter/2021-10-06-vetenskaps…

https://www.lupop.lu.se/article/vetenskapsradets-samordningsuppdrag-om-oppen-tillgang-till-forskningsdata-delredovisning - 2025-08-29

Nu kan du anmäla informationssäkerhetsincidenter!

Har du tappat bort ett USB-minne med känsliga uppgifter? Eller har du sett någon stryka omkring i universitetets lokaler med en möjlig avsikt att tillskansa sig värdefull information? Det finns gott om exempel på tänkbara informationssäkerhetsincidenter som måste anmälas. En informationssäkerhetsincident är ”en oönskad händelse med negativa konsekvenser som handlar om säkerheten för information".

https://www.lupop.lu.se/article/nu-kan-du-anmala-informationssakerhetsincidenter - 2025-08-29

Ny studie från Region Skåne: Återfall av Clostridium difficle

Vid verksamhetsområdet infektionssjukdomar på Skånes universitetssjukhus planeras en studie kring återfall av Clostridium difficile (nyligen namnbyte till Clodstridoides difficile). Studien ska utreda vilka faktorer som kan vara avgörande för att få fler återfall. Läs mer på https://www.lupop.lu.se/aterfall-av-clostridium-difficle

https://www.lupop.lu.se/article/ny-studie-fran-region-skane-aterfall-av-clostridium-difficle - 2025-08-29

Strength in causality: discerning causal mechanisms in the sufficient cause model

In this article, we discuss how to discern the causal mechanisms of interest in the sufficient cause model, which pays closer attention to the relationship between the sufficient cause model and the Bradford Hill viewpoints. Read the paper at https://link.springer.com/article/10.1007%2Fs10654-021-00798-6

https://www.lupop.lu.se/article/strength-causality-discerning-causal-mechanisms-sufficient-cause-model - 2025-08-29