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Narwhal tusks are among the most intriguing structures in biology due to their immense size and unique left-handed helix. Whether this unique macroscopic homochirality originates in the structural arrangement of tusk building blocks has remained elusive. Therefore, we combined multiple structural techniques to reveal the hierarchical structure of the narwhal tusk from its building blocks (minerali
Highlights: Two visual effects attributed to visibility: loss of contrast and loss of detail. Smoke and fog density affected headway during driving in virtual reality. Some participants followed the lead vehicle while others lagged behind. Limitations of virtual reality could have an impact on driving behavior. Abstract: Understanding human behavior during wildfire evacuations helps to improve the
We address how surface topology controls the multiscale flow alignment of cellulose nanocrystal (CNC) suspensions using a single in-situ experiment that combines rheology, polarized light imaging (PLI), and small-angle X-ray scattering (SAXS). Across a series of azetidinium-based dialkyl linker topologies, we resolve the propagation of alignment from the mesoscale (PLI) to the nanoscale (SAXS). Wh
Background Pain, fatigue, and impaired health-related quality of life are common manifestations of rheumatoid arthritis. The aim of this study was to compare the effects of active conventional treatment with three different biological disease-modifying antirheumatic drugs (DMARDs) on patient-reported outcomes after 48 weeks, in patients with early rheumatoid arthritis using data from the NORD-STAR
BACKGROUND Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has improved outcomes for patients with peritoneal carcinomatosis (PC). However, this treatment carries a significant risk of acute kidney injury (AKI), especially with cisplatin-based regimens. Sodium thiosulfate (ST) is established as a nephroprotective treatment in cisplatin-based HIPEC, but i
Aim: The randomized COLOPEC trial demonstrated no benefit of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in preventing peritoneal metastases in locally advanced colon cancer. Because all patients underwent a diagnostic laparoscopy at 18 months, the study lacked a true control arm, leaving the effect of early detection and treatment compared with standard care uncertain. This study a
The same dataset can be analysed in different justifiable ways to answer the same research question, potentially challenging the robustness of empirical science1, 2–3. In this crowd initiative, we investigated the degree to which research findings in the social and behavioural sciences are contingent on analysts’ choices. We examined a stratified random sample of 100 studies published between 2009
AbstractBackgroundMinimally invasive surgery (MIS) improves short-term outcomes in elective colectomy, however, the choice of surgical approach in hemodynamically stable patients with obstructing right-sided colon cancer remains unclear in emergency settings. MIS could be considered and the present study aims to evaluate short-term outcomes of MIS in bowel obstructed patients compared with open su
Macrocyclic peptides are a growing class of pharmaceuticals, due to their high target specificity and improved properties, solubility, permeability and metabolic stability compared to linear peptides. Disulfide bonds are commonly used as linkers; however, disulfide bonds are proven to be metabolically instable. This study explores alternative linkages to replace the disulfide bond for two existing
Till följd av Helsingborgs urbana expansion har hamnverksamheten successivt flyttats längre söderut, vilket lämnade kvar en serie magasinbyggnader. Magasin 405 användes tidigare som lager för gods som lossades från fartyg som passerade genom Öresund. Präglad av sitt industriella förflutna besitter byggnaden en rad arkitektoniska kvaliteter, med en robust betongstruktur dimensionerad för tunga last
The Lean Startup Methodology (LSM) has become a near-canonical heuristic for early-stage venture building, yet its empirical foundation remains thin and its applicability to artificial intelligence (AI) ventures is under-theorised. AI-native startups operate under conditions that strain the methodology’s core assumptions: outputs are probabilistic rather than deterministic, performance is continge
This article exposes the invisible sand that underpins Copenhagen’s transformation from fishing village to global city. By “following sand,” we trace how planetary material flows sustain urban expansion while entangling the city in processes of capital accumulation, class restructuring, and ecological degradation. Drawing on Science and Technology Studies (STS) approaches, yet situating them firml
In this submission, we show the role of pollinators in sustainable food production, food security, and human rights, and the negative impact of agribusiness commercialized pesticides on pollinators and on a wide range of human rights. We identify the role of judicial and nonjudicial mechanisms in preventing these pesticides’ impacts as well as on access to justice, including remedy. Ultimately, we
This contribution to the conference on Transitioning away from Fossil Fuels focuses on thematic pillar 3 which addresses the advancement of international cooperation and climate diplomacy. The Fossil Fuel Treaty Initiative represents an opportunity to align climate ambition with human rights and biodiversity stewardship. We consider this stage of the process a crucial waypoint for responding in a
Esta contribución a la Primera Conferencia Internacional sobre la Transición hacia la no proliferación de Combustibles Fósiles se centra en el pilar temático 3, relativo al avance de la cooperación internacional y la diplomacia climática. La Iniciativa del Tratado de No Proliferación de Combustibles Fósiles (en adelante, Iniciativa FFNPT, por sus siglas en inglés) representa una oportunidad para a
