Filtyp
Introduction: Early-life determinants of middle-age cardiovascular health are poorly understood. This study examines associations of BMI and physical fitness in male adolescents with cardiovascular health measured by the Life's Essential 8 score in middle age. Methods: A population-based cohort study linked BMI and physical fitness from the Swedish Military Conscription Register (men conscripted f
Damage, failures, and defects in buildings create an enormous cost for stakeholders. This study examined technical aspects of inadequate management and maintenance causing moisture and indoor environment related damage instances. Using a dataset of 2100 diagnosed causes of damage based on real damage investigations carried out in Sweden, several of the factors causing damage were identified. The c
Amelogenin, the most abundant protein in developing enamel, self-assembles into supramolecular structures that serve as templates for apatite growth. Recent studies revealed that amelogenin nanoribbons exhibit hallmark features of functional amyloids, yet the molecular mechanisms governing their formation remain incompletely understood. Here, we combine atomic force microscopy, transmission electr
Introduction: Chronic pain is among the most common side effects of cancer in cancer patients and survivors, often co-occurring with fatigue, emotional distress and elevated fears of cancer recurrence. Both pain and the associated difficulties are associated with poorer outcomes. Longitudinal studies are needed that identify psychosocial factors that mitigate the effects of chronic cancer-related
Background Bariatric metabolic surgery (Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG]) effectively treats obesity and type 2 diabetes; however, weight loss varies, necessitating predictive factors. Methods We analysed 12- and 24-month weight loss data from 811 patients (RYGB or SG). Factor Analysis of Mixed Data and neural network (NN) modelling identified distinct patient phenotypes
Oats ( Avena sativa ) are commonly kilned to inactivate native lipases, yet the impact of kilning on the storability of oats is not fully understood. In this study the impact of kilning on five different oat varieties during 12 months of continuous storage was investigated. The study included three commercial oat varieties with different lipid contents, and two novel oat lines selected for decreas
Developing radiation tumor biomarkers that can guide personalized radiotherapy clinical decision making is a critical goal in the effort towards precision cancer medicine. High-throughput molecular assays paired with modern computational techniques have the potential to identify individual tumor-specific signatures and create tools that can help understand heterogenous patient outcomes in response
This study presents a simulation-based framework for evaluating energy renovation strategies across European building typologies and climate zones. A factorial parametric approach was used to simulate over 800,000 combinations of envelope assemblies, HVAC systems, and shading controls for three archetypes (single-family, multi-family, office) across five European climate zones under both current a
BACKGROUND: The isolation of cell-free DNA (cfDNA) from the bloodstream can be used to detect and analyze somatic alterations in circulating tumor DNA (ctDNA), and multiple cfDNA-targeted sequencing panels are now commercially available for Food and Drug Administration (FDA)-approved biomarker indications to guide treatment. More recently, cfDNA fragmentation patterns have emerged as a tool to inf
The International Agency for Research on Cancer has recently classified occupational exposure as a firefighter as carcinogenic (group 1A). Even though the occupation of firefighter is associated with high exposure to pollutants, it is challenging to carry out exposure studies to assess health risks due to the extreme conditions associated with firefighting. Routine monitoring of occupational expos
Introduction: The first-line evidence-based treatment for chronic pain is multidisciplinary treatment involving pain-focused CBT. Studies have shown that changes in psychological flexibility (PF) during pain-focused CBT positively mediatesoutcomes, even when the treatment does not specifically target PF. While CBT and PF-based treatments for chronic pain yield small to moderate, but clinically mea
In collisions between heavy nuclei, such as those at the Large Hadron Collider (LHC) at CERN, hydrodynamic models have successfully related measured azimuthal momentum anisotropies to the transverse shape of the collision region. For an elliptically shaped interaction area, the hydrodynamic pressure gradient is greater along the minor axis, resulting in increased particle momentum in that directio
Coastal port cities are key regions for carbon emissions (CEs) research in China, due to their industrial density, frequent transportation, and diverse human activities. Taking Ningbo City as a case study, this study employed a top-down accounting method and integrated multiple sources of geospatial data to reveal the spatiotemporal distribution characteristics of CEs from four sectors, including
Background: Approximately 40% of cancer patients/survivors develop chronic cancer-related pain (CRP), which is often associated with greater levels of fatigue and cancer worry, all of which are associated with poorer functioning, wellbeing, and greater healthcare costs. Psychological Flexibility (PF) refers to one’s level of openness to and acceptance of physical/emotional experiences and willingn
Widespread vegetation changes have been evidenced by satellite-observed long-term trends over decades in vegetation indices (VIs). However, many issues can affect the derived VIs trends, among which the inherent difference between VIs calculated from the same input reflectance has not been investigated. Here, we compared global long-term trends in six widely used RED-NIR (near-infrared)-based VIs
BACKGROUND: Obesity represents a significant public health challenge, particularly in the context of coexisting chronic diseases and multi-morbidity. In Spain, and specifically in Catalonia, primary care plays a central role in prevention and management, yet barriers such as weight-related stigma can compromise care delivery.AIM: To evaluate the current state of obesity prevention and management w
Background: Low-molecular-weight heparin (LMWH) is recommended for thromboprophylaxis in adult intensive care unit (ICU) patients. Despite its widespread use, there is insufficient evidence on the optimal dose, and there appears to be practice variation. Determining the LMWH dosing strategy that most effectively balances the risks of venous thromboembolism (VTE) and bleeding may improve outcomes i
Introduction: Preclinical studies have demonstrated the ability of FLASH irradiation to expand the therapeutic window by sparing normal tissues. The heart is a critical organ at risk in patients receiving radiotherapy for thoracic cancers. This study aimed to quantify the cardiac sparing effects of photon FLASH delivered as single (FLASH) or FLASH split dose (FSD) exposures. Methods: Female C57BL/
