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Background The objective of this study was to provide a multimodal biomarker characterization of amnestic objective subtle cognitive decline (obj-SCD) in aging and preclinical Alzheimer’s disease (AD). Methods Prospective observational study; data from the Alzheimer’s and Families+ (ALFAs+) cohort, including cognitively unimpaired (CU) individuals with available baseline CSF biomarkers (normal or
Background: Stroke is the second leading cause of death and the third leading cause of disability worldwide, with global economic costs exceeding US $890 billion annually and a projected 50% rise in deaths between 2020 and 2050. So far, stroke has been addressed within the World Health Organization (WHO) Global Noncommunicable Disease (NCD) Action Plan 2023–2030 and the Intersectoral Global Action
Background Obstructive sleep apnea (OSA) frequently coexists with coronary artery disease (CAD) and may contribute to heart failure with preserved ejection fraction (HFpEF). Whether HFpEF-like features are reversible with continuous positive airway pressure (CPAP) therapy remains uncertain. Methods A total of 177 revascularized CAD patients with nonsleepy OSA (Epworth Sleepiness Scale score <10; a
CD8 + T-cell presence and distribution in oropharyngeal cancer (OPC) reflects specific immune phenotypes and are linked to prognosis. Image processing methods such as convolutional neural networks (CNN) may enhance treatment decisions. From standard computed tomography (CT) images, this study evaluates radiomics in combination with machine learning models and CNN for prediction of spatially resolv
Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26;
Problem description: Warehousing is central in order to achieve a competitive supply chain, and considered essential for the success, or failure, of businesses today. In general, warehouses account for a large share of the company logistics costs. Consequently, there is a need for warehouses to operate smoother, faster and more accurate. Within warehousing, the most labor-intensive and costly ware
Urban mobility as we know it is changing. On the one hand, challenges persist ranging from climate change, increasing urbanization and demographic change. On the other hand, recent technological advances enable novel approaches to mobility altogether. This paper investigates Personal Rapid Transit (PRT) as one such innovative mobility form in the context of the changing urban mobility paradigm. Du
The healthcare sector, currently accounting for about seven percent of global GDP expenditure, faces growing demand pressures driven by factors such as ageing populations and growing prevalence of chronic diseases. Consequently, the sector is increasingly looking for innovations that can simultaneously improve the efficiency and quality of care. Healthcare innovations could in turn make large cont
This study aims to answer two research questions with focus in Sida’s International Training Program: Child rights, classroom and school management, the two questions regard the knowledge transfer process. The first one focuses on how the participants of the program express knowledge and knowledge transfer and the second one highlights what contextual factors that affect the processes on three dif
Bakgrund: Personer med funktionshinder är en utsatt grupp i låginkomstländer. För att kunna uppnå bästa möjliga fysiska förmåga hos personer med funktionshinder så att de kan vara en aktiv del av samhället behövs omfattande rehabiliteringsinsatser. På Haiti råder en kritisk obalans mellan behovet av rehabilitering och landets förmåga att tillhandahålla dessa tjänster. Syfte: Att undersöka hur reh
Studiens syfte var att undersöka huruvida evaluativitet var en faktor som påverkade upplevelsen av person organization fit (P-O fit), vilket innebär samstämmighet mellan individ och organisation. Evaluativitet definierades i den här studien som en persons tendens att beskriva sig själv i positivt värdeladdade termer och i sin självbeskrivning uttrycka sig på ett sätt som anses vara socialt önskvärThe purpose of this study was to examine whether the evaluative factor influences the perception of person organization fit (P-O fit), which implies congruence between an individual and an organization. Evaluativity was defined, in this study, as an individual who has a tendency to describe herself in positive evaluative terms, and in her self-description uses expressions that are socially desirab
Studiens främsta resultat är ett bidrag till analysen av begreppet egenmakt (”empowerment” på engelska) i förhållande till akademiska institutioner. I vår studie har vi i första hand fokuserat på lärande och forskande personal och finner att egenmakt för dem kan skapa en stark självkänsla och arbetstillfredsställelse men samtidigt kan den också skapa en situation där det är svårt för den enskilde
The aim of this thesis is to look at volatility spillovers between the exchange rate changes and the stock market returns. The theoretical relationship between the exchange rate and stock market is covered with focus on two basic models, the stock oriented model and the flow oriented model. The relationship between the two variables is positive in the stock oriented model while it is negative in t
Våld mellan idrottsutövare är ett udda ämne som det inte reflekteras mycket över. I denna uppsats har avsikten varit att belysa problematiken kring våldet på den idrottsliga scenen, där förgrundsfigurerna själva står i centrum. Forskningsansatsen har varit att initialt visa på de skillnader som finns i våldsbedömning mellan ishockeyns disciplinnämnd kontra den allmänna rätten. Därefter förklara va
Urban land-use planning, which is a useful tool for the sustainable development of a city, is a complex decision making process. However, the modern GIS technologies facilitate such complex jobs in two ways – (i) GIS allows to work with large numbr of datasets, (ii) a number of methods, techniques or models could be embeded in GIS for land-use suitability analysis. Analytical Hierarchy Process (AH
Infant (<1 year of age) acute lymphoblastic leukemia (ALL) is a malignancy characterized by rearrangements of the lysin-specific methyltransferase 2A (KMT2A/MLL) gene at 11q23 in 80% of cases and with a very poor outcome. Recently, we identified recurrent mutations in FLT3 (FLT3N676K) and PIK3R1 (PIK3R1Y580fs, PIK3R1Y580*) through whole genome sequencing of infant ALL. To gain a better understandi
The purpose of this thesis is to examine the capacity of the Swedish railway network and try to centre upon rail freight; will the Swedish railway net be able to handle future demands of railway freight? To accomplish this consumed capacity was calculated for different parts of the rail network. Not the whole network was selected, parts that had more than six good trains per day in 2011. To be abl
Case managers and Case management were implemented in the Swedish mental health care system as a result of political policies which aimed towards the empowerment of mentally disabled clients. This thesis engages the implementation of policy into local practice in terms of a translation process performed by case managers as they go about understanding and handling their everyday labour conditions.
The main objective in this project is to study the seed dispersal and seed predation for the tree Pycnanthus angolensis in the Nigerian rainforest, and to evaluate the impacts of bushmeat hunting. One of the problems with bushmeat hunting is that it can disrupt the dispersal dynamics of forest trees. Bushmeat hunting is a widespread problem in the whole of Africa. The meat of wild forest animals a
