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BACKGROUND: Homologous recombination deficiency (HRD) originating from inactivation of genes like BRCA1/BRCA2 is a targetable abnormality common in triple-negative breast cancer (TNBC). In estrogen-receptor (ER)-positive HER2-negative (ERpHER2n) breast cancer (BC), HRD prevalence and clinical impact are unclear.METHODS: We analyzed 502 ERpHER2n tumors from patients recruited via the population-rep
BackgroundMolecular subtypes of lung adenocarcinoma (LUAD) with varying prognosis and characteristics have been proposed based on one or two-dimensional studies but are not yet implemented into clinical routine. Epigenetic modifications in cancer cells are independent of sequence variants, directly linked to gene and genome regulation, and thus provide important information to guide subclassificat
The sharing economy generates many benefits for cities and their citizens. However, it also causes numerous economic, social and environmental challenges, which are the reasons cities develop various policies and regulations. Previous research has explored municipal regulations across cities and countries but often overlooked alternative governance mechanisms. Our earlier work highlighted the need
As the impact of climate change intensifies, there is an urge to adapt Swedish residential buildings with a special focus on improving their energy efficiency and resilience. In this study, adaptive strategies through Artificial Intelligence and Reinforcement Learning will be provided for the energy management of different Swedish residential buildings. The aim will be the optimization of energy u
Individual’s future socioeconomic status (SES) has been reported to be robustly predicted by cognitive ability (IQ). However, research on the genetic and environmental underpinnings of this association in emerging adults remains limited. Utilizing the German TwinLife panel data, the present study examined how IQ at early adulthood at age 23 is associated with SES at age 27 (NMZ = 228 and NDZ−SAME
Background: Women who have undergone cervical conization may still experience subsequent pregnancies and delivery. However, it remains unknown whether pregnancy, associated with immune tolerance, might increase the risk of subsequent cervical lesions. This study aims to address this knowledge gap by utilizing the nationwide Swedish registers. Methods: A total of 60,895 women diagnosed with cervica
Plant functional traits are fundamental to ecosystem dynamics and Earth system processes, but their global characterization is limited by available field surveys and trait measurements. Recent expansions in biodiversity data aggregation—including vegetation surveys, citizen science observations, and trait measurements—offer new opportunities to overcome these constraints. Here we demonstrate that
A classical state-preparation device cannot generate states in relative superposition. We introduce classical models in which devices that are individually unable to generate states with relative superposition can be stochastically coordinated to simulate sets of quantum states. These models have natural operational interpretation in prepare-and-measure scenarios and they can account for many non-
With the recent advances in graph neural networks, there is a rising number of studies on graph-based multi-label classification with the consideration of object dependencies within visual data. Nevertheless, graph representations can become indistinguishable due to the complex nature of label relationships. We propose a multi-label image classification framework based on graph transformer network
Medulloblastoma and glioblastoma are the most common malignant primary brain tumors in children and adults, respectively. Tumor-associated macrophages and microglia are key non-cancerous cell types in these tumors. These cells interact with CD24, a so called “don’t eat me signal” expressed on tumor cells, through Siglec-10, a receptor that contributes to immune evasion by promoting an immunosuppre
Background: This study investigated the moderating role of household disposable income and family type on the association between precarious employment (PE) and diagnosed mental disorders. Methods: This longitudinal study used register data from the Swedish Work, Illness, and Labour-market Participation (SWIP) cohort. The study population included all individuals aged 27–65 who were employed in 20
Aim: Predicting the time-activity curve (TAC) of [177Lu]Lu-DOTA-TATE for organs at risk and neuroendocrine tumours (NETs) is an essential element in the calculation of the absorbed dose (AD) and a critical step for individualising peptide receptor radionuclide therapy (PRRT) treatment planning. This study aims to predict the TAC of [177Lu]Lu-DOTA-TATE using a single quantitative image of [68Ga]Ga-
Background: Co-occurring substance use disorders, and mental disorders are associated with significant suffering, high risks of violent reoffending and relapse in both substance use and psychotic episodes. Treatment for co-occurring substance use disorders in forensic mental health settings would benefit from incorporating patients’ understanding of their disorders. Method: Using an interpretative
Living through war is more than surviving each day – it's rebuilding life, identity, and society in the shadow of constant threat.This volume offers a multidimensional portrait of Ukraine during the Russian invasion, bringing together real life stories, empirical research, and institutional analyses from scholars and practitioners at Zhytomyr Polytechnic State University and Lund University. It hi
Background: Our aim was to investigate change over time of passive range of motion (pROM) in the upper limbs of children with cerebral palsy (CP), treated or not treated with botulinum neurotoxin-A (BoNT-A). Methods: Data from 2000 to 2017 were collected from the Cerebral Palsy follow-up program and registry in Sweden (CPUP) for children with spastic or dyskinetic CP. Mixed models were used to ana
The lichen genus Lecanora is one of the largest genera of lichenized fungi. The core part of the genus is the L. subfusca group and within this group, Lecanora hybocarpa (Tuck.) Brodo, initially described from North America and thought to be endemic, has been reported from several European countries. However, the identity of these European specimens has been increasingly questioned. This study aim
Background Preserved ratio impaired spirometry (PRISm) and restrictive spirometry pattern (RSP) are associated with increased morbidity and mortality, but the underlying mechanisms are unclear. Impulse oscillometry (IOS) measures small airway function more sensitively than spirometry. We aim to study the prevalence of abnormal IOS findings in relation to three spirometry patterns (obstructive, PRI
Background: To evaluate whether integrating proteomics, metabolomics, and a cardiovascular disease specific polygenic risk score (CVD-PRS) in the SCORE2-Diabetes model improves sex-specific 10-year prediction of major adverse cardiovascular events (MACE) in individuals with type 2 diabetes (T2D). Methods: Genome-wide association study (GWAS), plasma proteomics (with the Olink Explore 3072 platform
Background Exertional breathlessness is a limiting symptom that often coexists with anxiety and depression. We tested the hypothesis that anxiety and depression negatively impact exertional breathlessness in daily life and during standardised cardiopulmonary exercise testing (CPET). Methods Analysis of people aged ⩾40 years undergoing incremental cycle CPET. Exertional breathlessness in daily life
Aim: Assess healthcare utilization and direct costs for heart failure (HF) during the first two years post-diagnosis across HF subgroups. Methods: This retrospective population-based study included patients with HF aged 40–90 years in Region Halland. HF subgroups were defined based on echocardiographic ejection fraction, including HF with reduced ejection fraction (HFrEF), mildly reduced ejection
