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Objectives This study evaluates the cost-effectiveness of rechargeable (RC) and nonrechargeable, primary cell (PC) traditional and multimodal spinal cord stimulation (SCS) systems in combination with conventional medical management (CMM) compared with CMM alone in patients with persistent spinal pain syndrome type 2 (PSPS-2) with low back/leg pain that remains despite surgery. Material and Methods
This study investigates whether a genderless second language (L2; English) reshapes grammatical gender (GG) effects derived from two gendered first languages (L1s; Ukrainian and Russian) in multilinguals. Previous work showed that when GG aligns across these L1s, it influences categorisation and recall of multilinguals, whereas mismatching L1s yield effects from the more proficient L1 only on cate
Background Assessment of left ventricular function and dimensions is central for cardiac diagnostic imaging with cardiac positron emission tomography (PET) and myocardial perfusion single-photon emission computed tomography (MPS). The aim of this study was to compare [13N]NH3 PET and MPS, head-to-head, for assessment of left ventricular ejection fraction (LVEF) and volumes using cardiac magnetic r
Purpose: – We sought to develop an equation, the Alma College Estimation (ACE) equation, to estimate survival equivalent to the Duke treadmill score (DTS) and Duke nomogram. Methods: – Combinations of ST segment deviation (0, 1, 2, 3, and 4 mm), angina (0 = none, 1 = nonlimiting, and 2 = limiting), and metabolic equivalents of task (2–20) were graphed on the Duke nomogram, and the ACE equation was
Aim: To explore a set of psychosocial and behavioural correlates of self perceptions of aging among geriatric healthcare professionals. Findings: Higher psychological resilience was associated with lower perceptions of psychosocial loss and more favourable views of ageing as psychological growth, while subjective age showed a strong association with the interpretation of physical changes. Physical
Från de första kyrkorna på 900-talet och fram till idag har kyrkor uppförts och försvunnit igen. Kyrkor har ersatts av nya på samma plats eller på andra platser. Kyrkor har även lagts ner av olika anledningar. Kyrkorna har således både ökat och minskat i antal. Idag har många kyrkor blivit övertaliga och används därför mer sällan, i några fall tillåts de förfalla, får nya funktioner eller säljs. TFrom the first churches in the 9th century to the present day, churches have been built and then disappeared again. Churches have been replaced by new ones in the same or other locations. Or churches have been closed for various reasons. The churches have thus increased in number and decreased again. Today, many churches have become redundant and are therefore used less frequently, in some cases t
We introduce MEGATRON, a new galaxy formation model for cosmological radiation hydrodynamics simulations of high-redshift galaxies. The model accounts for the non-equilibrium chemistry and heating/cooling processes of ≥ 80 atoms, ions, and molecules, coupled to on-the-fly radiation transfer. We apply the model in a cosmological setting to the formation of a 109 M⊙halo at z = 6, and run 25 realizat
Hemophilia A and B are rare, X-linked bleeding disorders characterized by deficiencies in coagulation factor VIII (FVIII) and factor IX (FIX), respectively. Numerous advances have helped to reduce disease burden. However, hemophilia B is not as well studied as hemophilia A, likely reflecting its lower prevalence. Clinical management of hemophilia B has often relied on inference and extrapolation f
Previous research in various educational areas has shown that literary texts have much to contribute through offering perspectives, contexts, and ways of presenting content. The present study has a particular focus on science education. The purpose of science education is under debate, and research as well as large-scale frameworks such as PISA increasingly highlight student agency and action comp
This study examined whether Growth Differentiation Factor-15 (GDF-15) and echocardiographic measures of systolic left ventricular function improve intermediate- and long-term mortality risk prediction beyond the guideline-endorsed GRACE 2.0 score after Acute Coronary Syndrome (ACS). 751 ACS patients were included. GDF-15, left ventricular ejection fraction (LVEF), and global longitudinal strain (G
Preconception health status, especially of women, but also of men, is known to influence pregnancy outcomes. Despite knowledge of the growing importance of preconception health, numerous challenges remain for conducting research in this population and delivering appropriate clinical care. The 2023 Global Pregnancy Collaboration annual workshop focused on exploring preconception health as it relate
The growing challenge of antibiotic resistance calls for alternative therapeutic strategies beyond conventional antibiotics. Antibacterial Photodynamic Therapy (aPDT), based on the light-induced generation of Reactive Oxygen Species (ROS), offers a non-specific approach that is detrimental to bacterial cells at multiple levels. Here, we explore the photocatalytic properties of nitrogen-doped titan
Oats (Avena sativa L.) are gaining increased attention for their rich dietary fibres, proteins and bioactive compounds. Among fibres, starch components denoted as resistant starch (RS) contribute significantly to the functional and nutritional properties of oat-based foods. This study presents the optimization of a high-throughput quantification method for amylose, a key structural component that
Urbanisation, digitalisation and emerging technologies are reshaping young people’s relationship with the outdoor environment. We investigate how everyday outdoor experiences and spaces support adolescent wellbeing, understood as both feeling good and functioning well. Adolescents, at a pivotal stage in life, are particularly sensitive to environmental factors that influence their wellbeing. We co
Bacillus thuringiensis (Bt) strains naturally produce pesticidal proteins as nanocrystalline inclusions that are extraordinarily stable in aqueous environments, but which dissolve selectively at specific pH conditions. These proteins have been used in agriculture for >50 years and are critical to global food security. The majority of previously determined Bt Cry protein structures lack the extende
Atmospheric vapor pressure deficit (VPD) is a key climatic factor that influences vegetation productivity and the global carbon cycle. With ongoing climate warming, VPD has been rising globally. However, the effects of this increase on gross primary production (GPP), especially under different driving mechanisms, remain unclear. This uncertainty limits our ability to predict terrestrial ecosystem
Neuroinflammation emerges as a central driver of neurodegeneration, yet the molecular regulators orchestrating pathological microglial activation remain incompletely understood. This thesis investigates galectin-3 (Gal3), a glycan-binding protein with dual roles in microglial homeostasis and inflammatory signaling, as a master regulator linking neuroinflammation to proteinopathy progression in Alz
Studio recordings of music for English bass horn and string trio from the composers Louis Massonneau, Emma Jane Lloyd, and Ylva Lund Bergner, recorded at the St Cecilia's Hall in Edinburgh on 17 January 2026.
