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Purpose: Accurate non-invasive prediction of histopathologic invasiveness and recurrence risk remains a clinical challenge in resectable non-small cell lung cancer (NSCLC). We developed and validated the Edge Proximity Score (EPS), a novel [18F]FDG PET/CT-based spatial imaging feature that quantifies the displacement of SUVmax relative to the tumor centroid and perimeter, to assess tumor aggressiv

Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionna

Prurigo nodularis (PN) is a chronic, itchy, inflammatory skin condition that negatively affects quality of life. A study was undertaken to investigate the healthcare utilization, including treatment patterns and direct costs for specialist care, for PN in Sweden. Linkage cohorts were created from national Swedish patient and prescription registers, and the cost-per-patient database of PN adults in

Background and objective: Prostate cancer (PC) is the second most common cancer and a leading cause of death among males. In this systematic review we evaluated cohort studies and randomized controlled trials (RCTs) on the relationship between dietary patterns and PC risk, progression, mortality, and biomarkers. Methods: A systematic search of MEDLINE, Embase, and Cochrane Central was conducted th

The properties of elementary excited states in the B850 band of the peripheral light-harvesting antenna (LH2) of the photosynthetic purple bacterium Rhodobacter sphaeroides has been studied at room temperature by means of femtosecond transient absorption experiments combined with computer simulations. Polarized pump-probe kinetics have a fast component of 100 and 65 fs for the anisotropic and isot

The doorway-window representation of sequential pump-probe spectroscopy, derived by solving the nonlinear exciton equations, is used to study exciton dynamics in molecular aggregates. Exciton relaxation is incorporated through a multilevel Redfield relaxation superoperator calculated using the Brownian oscillator spectral density for the collective phonon coordinates. Optical pulses are included u

Background: We set out to profile the immune mechanisms active in treatment-naïve oligoarticular JIA (oJIA) to improve the knowledge of its immunopathogenesis, to identify potential biomarkers that can aid diagnosis, predictions and that correlate with clinical disease parameters. Methods: Using Olink proteomics (inflammation panel measuring 92 markers), we defined and compared the inflammation pr

The temporal evolution of the transient absorption response of light‐harvesting antennae and dye molecules was studied. Using 40—90 fs pulses coherent nuclear motions were observed in intact membrane‐bound photosynthetic light‐harvesting pigment‐protein complexes, bacteriochlorophyll α monomer and dye molecules in solutions. Computer simulations based on the harmonic Franck—Condon approximation an

Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de

Homelessness has increased significantly in Sweden since the early 1990s. A national survey of homelessness in 2023 showed that 27,383 people were in one of the four homelessness situations that are used in Sweden, namely 1) Acute homelessness, 2) Institutional and supported housing, 3) Long-term housing organised by the municipality and 4) Short-term accommodation arranged on one’s own. These homHomelessness has increased significantly in Sweden since the early 1990s. A national surveyof homelessness in 2023 showed that 27,383 people were in one of the four homelessnesssituations that are recognised in Sweden, namely: (a) acute homelessness; (b) institutional orsupported housing; (c) long-term housing organised by a municipality; and (d) short-termaccommodation arranged by people themselv

Background: Autoantibodies against β-cell components in the pancreatic islets of Langerhans are characteristic of type 1 diabetes (T1D). The genetic and autoimmune determinants of type 1 diabetes (T1D) in Ethiopians are not yet thoroughly characterized, with studies indicating a lower occurrence of autoantibodies related to T1D compared to Caucasians. The study aimed to determine the occurrence of

Background: The study aimed to analyze thyroid-stimulating hormone (TSH) levels quantitatively and investigate their potential correlation with the risk of incident atrial fibrillation (AF) in differentiated thyroid cancer (DTC) patients. Methods: DTC cases diagnosed between 1995 and 2015 in Stockholm, Sweden, were identified from the Swedish Cancer Registry. Medical records were scrutinized, and

Relational memory retrieval entails a dynamic interplay between eye movements and neural activity, yet the temporal coordination of these processes remains unclear. We examined how theta- and alpha-band EEG activity relates to sequential fixations during relational memory retrieval. Participants performed a two-alternative forced-choice associative memory task while eye movements and EEG were reco

A major target of the Marxist critique of “post-theory”—a broad term encompassing post-structuralism, post-Marxism, and postcolonial theory—has been its notorious deconstruction of the subject. The affirmation of marginal, excluded, and deviant subject positions within the same corpus has been noted less frequently. To recalibrate the Marxist critique of post-theory to also encompass its affirmati

Real-time 3D reconstruction is crucial for immersive AR/VR but is hard to achieve with traditional photogrammetry and mesh-based pipelines due to latency and limited scalability. Neural Radiance Fields (NeRF) enable high-quality novel view synthesis but suffer from long training and slow rendering, while Gaussian Splatting (GS) achieves real-time rendering at the cost of heavy preprocessing and me

Få aspekter av våra liv bidrar lika mycket till vår identitet och som källa till men- ing som arbetet. Samtidigt är behovet av mänsklig arbetskraft för att tillfredsställa grundläggande mänskliga behov mindre än någonsin, en tendens som kan komma att accelereras ytterligare de närmaste årtiondena till följd av ny teknologi. I mitt examensarbete försöker jag ta mig an frågan vad arbete egentligen äFew aspects of our lives contribute as much to our identity and sense of meaning as work. At the same time, the need for human labour to satisfy basic human needs is lower than ever—a trend that may accelerate further in the coming decades due to new technologies. In my thesis, I attempt to explore the question of what work actually is, the role it plays in our lives and in society, how it has bee

Energy transfer within various LH2 antenna complexes of the photosynthetic purple bacteria Rhodobacter sphaeroides and Rhodopseudomonas acidophila has been studied at 77 K using tunable femtosecond and subpicosecond infrared pulses. The complexes examined include the wild-type B800-850 as well as three different specifically mutated complexes. The site-directed mutant strains were altered at posit

Energy transfer within the peripheral light-harvesting antenna of the purple bacteria Rhodobacter sphaeroides and Rhodopseudomonas palustris was studied by one- and two-color pump-probe absorption spectroscopy with approximately 100-fs tunable pulses at room temperature and at 77 K. The energy transfer from B800 to B850 occurs with a time constant of 0.7 +/- 0.05 ps at room temperature and 1.8 +/-