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Objective To assess patient's self-reported global assessment of health (PGA) in relation to inflammation, pain and disability in patients with rheumatoid arthritis (RA). Methods Data were obtained from the Better Anti-Rheumatic PharmacOTherapy early RA cohort, in which patients were scheduled for follow-up of 15 years. Longitudinal PGA trajectories were identified using hierarchical agglomerative

The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer’s disease (AD) are lacking and the relationship to the Apolipoprotein-E (APOE) genotype is unclear. Investigating the PREVENT-AD dataset, we assessed

The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in older adults can be underestimated because of a delay in the development of mass effect and symptoms of intracranial haemorrhage. Management and rehabilitation in older adults must consider comorbidit

The catalytic conversion of carbon dioxide (CO2) to methanol over Cu/ZnO catalysts is expected to become valuable for recycling CO2. The nature of the Cu-Zn interplay remains a subject of intense debate due to many different Zn species encountered in Cu/ZnO catalysts. In this study, we designed a Cu-Zn catalyst by ion-exchanging Cu into CIT-6, a crystalline microporous zincosilicate with the BEA*

High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale

AIMS: Diet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features.METHODS AND RESULTS: The cross-sectional population-based study using data from the Swedish CArdioPulmonary BioImage Study (SCAPIS) included 24 079 adults aged 50-64 years, recruited

BACKGROUND: This systematic review aims to determine the loads of anti-A and anti-B in plasma-containing blood products that can safely be transfused to adults.MATERIALS AND METHODS: A comprehensive literature search was performed in PubMed, including studies dating back to 1940 until January 1 st, 2023. In total 1,869 articles were screened, describing 86 cases of hemolytic transfusion reactions

Background and Aims: Population-based data on prescribed opioid use among adults with Crohn's disease (CD) remain limited. Methods: This nationwide register-based study included individuals ≥ 18 years with incident (2008–2019) or prevalent (2008–2021) CD and up to 10 individually matched reference individuals without inflammatory bowel disease. We categorised opioid dispensations as weak (e.g., tr

Background: Adrenaline (ADR) is a cornerstone of advanced life support (ALS) in cardiac arrest (CA), although its neurologically favourable survival outcomes remain unclear. ADR increases coronary perfusion pressure (CPP), with levels >15 mmHg associated with successful defibrillation. This study aimed to elucidate the relationship between ADR, myocardial microvascular blood flow, and resuscitatio

Aim of the review: To provide an overview of studies that have published dataregarding region and population size, procedure location, team composition, inclusionand exclusion criteria, outcome parameters, and cost–benefit analyses onextracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.Data sources: A structured systematic literature search of articles published pr

Aim of the review: This review aimed to evaluate the impact of Point-of-care Ultrasound during cardio- pulmonary resuscitation for adult non-traumatic CA on clinical outcomes and survival.Data sources: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The PubMed and Embase databases were searched on 14 November 2022. The

After a decade of data falsification scandals and replication failures in psychology and related empirical disciplines, there are urgent calls for open science and structural reform in the publishing industry. In the meantime, however, researchers need to learn how to recognize tell-tale signs of methodological and conceptual shortcomings that make a published claim suspect. I review four key prob

Brandskum som innehåller per- och polyfluorerade ämnen (PFAS), på engelska Aqueuous Film Forming Foam (AFFF), är en av de främsta källorna till föroreningarna i Sverige. Grundvattenförorening orsakat av användandet av AFFF under brandövningar har undersökts i Kallinge, Blekinge. I området har grundvattnet använts som råvatten vilket resulterat i förhöjda halter av PFAS i dricksvattnet. Liknande faAqueuous Film Forming Foam (AFFF) containing Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) is one of the major sources of groundwater contamination in Sweden. Groundwater contamination caused by the use of AFFF in correlation to fire training events was investigated in Kallinge, Sweden. At the site groundwater was previously used as a drinking water source consequently affecting the inhabit

The formation of copper phosphide phases during brazing can negatively impact the mechanical properties of copper joints and the overall performance of the resulting product. For instance, copper tubes in air conditioning heat exchangers are brazed using Cu-P filler alloy, resulting in unnecessary brittle Cu₃P compounds. This study investigates a novel process of dephosphorization of copper phosph

PURPOSE: To explore modifications of the 2021 European Resuscitation Council/European Society of Intensive Care Medicine (ERC/ESICM) guideline algorithm for neuroprognostication after cardiac arrest to improve its prognostic accuracy.METHODS: Post-hoc analysis of four prospective multicentre studies (TTM, TTM2, KORHN and ProNeCA). We raised the Glasgow Coma Scale motor (GCS-M) inclusion threshold

This paper examines how, if artificial agents are capable of wellbeing, their wellbeing should be compared and aggregated alongside human wellbeing. Building on arguments from Goldstein and Kirk-Giannini, who suggest that some AI systems may possess wellbeing, I explore the moral implications of this possibility. Rather than reinventing debates in population ethics, this paper adapts and extends t

Multimedia environments consist of verbal and visual representations that, if appropriately processed, allow for the construction of an integrated mental model of the content. Whereas much is known on how students learn from verbal representations, there are fewer insights regarding the processing of visual information, alone or in conjunction with text. This chapter uses a semiotics approach to p

Perceiving and understanding human motion is a fundamental problem in computer vision, with diverse applications encompassing sports analytics, healthcare monitoring, entertainment, and intelligent interactive systems. Multi-camera systems, by capturing multiple viewpoints simultaneously, enable robust tracking and reconstruction of human poses in 3D, overcoming limitations of single-view approach

Studies investigating how the number of children in a family affects the parents or the children face problems because the variable of interestis endogenous in the model. The currently accepted solution to this problem is to use instrumental variables (IVs), for example, based on twin births. In this paper, I review and add to the critique of IVs based on twin births and show that that there are s