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Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. In 2023, it accounted for approximately 1.25 million deaths, including 161,000 among individuals living with HIV, making it the leading cause of death from a single infectious agent. The growing prevalence of multidrug-resistant TB (MDR-TB) further complicates treatment and contribu
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, yet clinical tools for diagnosis, prognosis, and treatment remain limited, and molecular profiling of histotypes is lacking. Here, we leverage proteomic data to further stratify four main EOC histotypes, borderline (BL) and benign (B) tumors, and identify candidate prognostic and diagnostic biomarkers. Using proteomic data
Hair analysis has been used in the past as a method to explore environmental exposure to chemicals, toxins or drug ingestion, with wide applications in forensic science, environmental studies, anthropology and medicine. Although not a conventional sample type, hair offers significant advantages over traditional biospecimens, such as blood or urine. These include its stability, non-invasive nature
Compact automated warehouse solutions are a challenge for conventional fire protection systems, such as sprinklers. As an option to sprinkler systems some warehouses employ an Oxygen Reduction System (ORS). When designing an ORS, the most important parameter is the limiting oxygen concentration (LOC). The level of protection attained is directly proportional to the oxygen level applied, which is a
The Industrial Symbiosis Readiness Level Matrix (ISRLM) tool presented in this paper, was developed to address the challenges inherent in implementing and managing Industrial Symbiosis (IS) networks. IS networks are complex systems involving diverse actors with varying levels of preparedness, perspectives, and priorities, which can result in miscommunication, inefficiencies, and slow implementatio
Habitat area, forest characteristics, management practices and protected areas have the potential to profoundly impact biodiversity. This is particularly true for specialist species linked to structural complexity and old forest, like the lesser spotted woodpecker (Dryobates minor). This study examines how habitat quality and quantity influence the occurrence of this Near-Threatened species across
In liquid-liquid chromatography (LLC), components of a mixture are separated due to their different distribution between the phases of a biphasic liquid system composed of two or more solvents. In this work, for the first time, we combine a chromatography model with a liquid-liquid equilibria thermodynamic model to simulate the propagation of the solute and the solvents along the LLC column. The m
Objectives: Our aim was to compare direct costs for single pill combinations (SPCs) and free-drug combinations for hypertension treatment. Methods: We focused on Australia as a case study and reviewed total costs, and for the patient and government. We reviewed the Australian “Pharmaceutical Benefits Scheme item drug map” considering different thresholds for the government safety net. Total costs
Over the past decade, numerous assays for forensic age estimation based on the analysis of DNA methylation markers have been developed, demonstrating significant potential for use in criminal investigations. Despite these advancements, only few comprehensive evaluation studies were published. In this study, we present findings of an extensive inter-laboratory evaluation of the VISAGE Enhanced Tool
The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between “resectable” and “unresectable” disease. Also, the use of preoperative systemic therapy has resulted in an increased frequency of disappearing liver metastasis (DLM). The optimal management of DLM is still controversia
ObjectiveTo evaluate if adding esketamine and clonidine has positive effects on postoperative pain, postoperative nausea and vomiting, and quality of recovery in patients who are at high risk for postoperative pain.DesignPatient- and assessor-blinded, superiority, randomised controlled trial.SettingSingle centre between 2022 and 2024.Patients125 adult patients, ASA I – II, planned for elective lap
This paper contributes to ongoing debates on inclusive place branding by introducing a feminist ethics of care approach. While existing research often treats inclusion as a strategic or instrumental move, aimed at enhancing collaboration or democratic legitimacy, it is rarely framed as an ethical imperative. Moreover, prevailing human-centred perspectives tend to marginalize non-human and environm
This study explores the online communication strategies of anti-tourism movements to evaluate their potential contributions to place branding—a topic that has received limited scholarly attention. While prior research often views such movements as antagonistic to place branding efforts, we challenge this assumption. Through an analysis of nine movements across five countries, we apply the typology
A radiation detection system combining a single-sided silicon strip detector (SSSD) and a high-purity germanium (HPGe) COMPEX detector module together with its anti-Compton shield (ACS) was set up at Lund University for environmental sample measurements. This system enables high sensitivity ––-coincidence analysis, enhancing the identification level of radionuclides in environmental samples. A com
Introduction: Depression and anxiety are leading contributors to the global burden of disease among women yet help-seeking for mental health concerns remains limited in lower-middle-income countries. This study aimed to estimate the prevalence of anxiety, depression, and help-seeking behaviors, and to identify factors associated with the absence of help-seeking among ever-married women of reproduc
While the 8.2 ka abrupt cooling event is increasingly recognised as a major Holocene climatic anomaly, archaeological discussions of its cultural consequences have often been framed in terms of societal distress, including the collapse and abandonment of settlements. However, prehistoric communities must have responded in more diverse ways. This paper investigates the site-based socio-ecological a
Located on the Pacific Ring of Fire, the extended Japanese archipelago is among the most geologically hazardous zones for human habitation located anywhere on the planet. Despite these threats and challenges, Japan has supported a series of unique cultures and societies that have evolved and changed over many millennia. The major existential risks include relentless volcanic eruptions, earthquakes
PURPOSE: Given the paucity of data regarding workplace risk of COVID-19, particularly from countries with limited lockdowns, we aimed to quantify the occupational risks of COVID-19-related hospital admission among workers in Sweden.METHODS: We identified 607,179 employed individuals, 20-69 years of age, in Skåne, Sweden. From December 31st, 2019-December 31st 2021, 2,633 incident COVID-19-related
Rationale, Aims and Objectives: Colonoscopy, though common, can be uncomfortable, necessitating routine assessment of patient experience per European guidelines. Positive patient experiences are crucial as they influence willingness for repeat procedures. Patient-reported experience measures (PREMs) effectively capture patient perspectives through surveys, empowering patients to influence healthca
