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Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder. Depositions of amyloid β peptide (Aβ) and tau protein are among the major pathological hallmarks of AD. Aβ and tau burden follows predictable spatial patterns during the progression of AD. Nevertheless, it remains obscure why certain brain regions are more vulnerable than others; to investigate this and dysregulate
Den sjätte studien är fokuserad på Supply chain risk management (SCRM), d.v.s. vi försöker förstå hur företag identifierar, analyserar och hanterar risker i sin försörjningskedja. Det gäller både i Risk Management i interna logistikflöden (egna lager, egna fabriker, transporter mellan egna anläggningar etc) men framför allt Supply Chain Risk Management i externa försörjningskedjor (leverantörer, u
Air cavities and gaps between material layers are common in construction systems, e.g. ventilated façades. Air cavity may provide a pathway for smoke and flame spread in case of fire. Performing physical testing to investigate different systems and fire scenarios is resource demanding. Fire Dynamics Simulator (FDS version 6.7.0) was used to simulate fire driven flow between two parallel vertical w
There is increasing evidence that environmental manganese (Mn) exposure early in life can have negative effects on children's neurodevelopment and increase the risk of behavioral problems, including attention deficit hyperactivity disorder (ADHD). Factors that may contribute to differences in sensitivity to Mn exposure are sex and genetic variation of proteins involved in the regulation of Mn conc
Background: Family risks for urinary tract cancers (excluding kidney cancers) are known, but less is known about whether rare urinary tract cancer subtypes are also familial and if urinary tract cancers share familial risk for other (discordant) cancers. Objective: To investigate the impact of family history on urinary tract cancers (International Classification of Diseases version 7 code 181) and
Per- and polyfluoroalkyl substances (PFAS) are extremely persistent manmade substances. Apart from exposure through food and indoor air and dust, humans can be exposed through drinking water if the surface or groundwater is contaminated. In 2013 very high levels of PFOS and PFHxS were found in the drinking water from one of the two waterworks supplying the municipality of Ronneby, Sweden. A cohort
The discovery of collectivity in proton–proton collisions, is one of the most puzzling outcomes from the first two runs at LHC, as it points to the possibility of creation of a Quark–Gluon Plasma, earlier believed to only be created in heavy ion collisions. One key observation from heavy ion collisions is still not observed in proton–proton, namely jet-quenching. In this letter it is shown how a m
Typhoon Haiyan hit the Philippines on 8th November 2013 destroying more than 1 million houses and affecting mostly the poor. This paper discusses user involvement in housing recovery from a capability perspective. The paper also analyses possibilities for extension of the housing solutions. Based on the Sphere handbook and the theoretical framework, a Model for user involvement in evolutionary hou
Purpose: Hardly anything is known about the aetiology of thymoma. This paper presents data regarding tobacco smoking and alcohol consumption in relation to thymoma from the first case-control study performed on this rare tumour. Methods: A European multi-centre case-control study including incident cases aged 35–69 years with thymoma between 1995 and 1997, was conducted in seven countries. A set o
Rapporten är en slutrapport för projektet ”Mätsystem för förändringsarbete”.Projektet syftar till att ta fram ett ramverk för mätning av förändringsarbete. Det innebär att ett mätsystem har utformats, implementerats, används och utvärderats i relation till Trafikverkets processer och avsikten med förändringsarbetet. Detta har skett genom en aktionsforskningsansats därforskarna samarbetat med två o
Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. Methods: This larges
Detta är en kort rapport inom projektet ”Mätsystem för förändringsarbete”, utfört vid Institutionen för teknisk ekonomi och logistik vid Lunds Tekniska Högskola. Rapporten skall ses som ett komplement till slutrapporten ”Mätning av förändringsarbete: Utveckling och implementering av ett mätsystem för att mäta förändringstemperatur”.Projektet syftade till att ta fram ett ramverk för förändringsarbe
Rapporten är en teoriöversikt över systematiska mätsystem och hur de kan utformas med hänsyn till olika perspektiv, såsom strategi, process, försörjningsnätverk och anläggning, men också för att ge en integrerad helhetssyn. Rapporten identifierar intressanta fördjupningsområden för framtida forskningsområden i uppdrag av Trafikverket.Med ett kritiskt förhållningssätt har en systematisk genomgång a
Objective To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). Methods The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody
Maillard reaction is an extensively studied, yet unresolved chemical reaction that occurs as a result of application of the heat and during the storage of foods. The formation of advanced glycation end products (AGEs) has been the focus of several investigations recently. These molecules which are formed at the advanced stage of the Maillard reaction, are suspected to be involved in autoimmune dis
Smart cities promise to generate economic, social and environmental value through the seamless connection of urban services and infrastructure by digital technologies (Hollands 2008, Viitanen and Kingston 2014), but there is scant evidence concerning their ability to enhance social well-being, build just and equitable communities, reduce resource consumption and waste generation, improve environme
The article argues for theorizing and studying the significance of how so-called leaders and followers converge or diverge in their views and understandings of the leadership/followership relations they may be part of. Divergence or misfits may be common yet missed by the researcher who takes only one party’s view of leadership into account and/or assumes that people involved define the relationsh
Ultra-high temperature (UHT) treatment of milk forms a deposit or fouling in the processing equipment that is mineral-based with an enclosed protein network. This study addresses the fundamental mechanisms that control the removal of this deposit. For this purpose, the structural and compositional changes during the cleaning process have been studied. The structure analysis was performed with scan
