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Developing efficient and robust computational models is essential to improve our understanding of protein solution behavior. This becomes particularly important to tackle the high-concentration regime. In this context, the main challenge is to put forward coarse-grained descriptions able to reduce the level of detail, while retaining key features and relevant information. In this work, we develop
Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been FDA-approved for lumbar fusion, but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast activation have limited its clinical usage. One strategy to mitigate the pro-osteoclast side effect of rhBMP-2 is to give systemic bisphosphonates, but it presents challenges with
How should democratic states approach and respond to secessionist movements using tactics contrary to the constitution to achieve their goals? What is the role of international human rights mechanisms in these processes? This article sheds light on these questions by examining how the UN Human Rights Committee approached and assessed two complaints that came before it in the wake of the Catalan De
A new growth approach, based on the hot-wall metalorganic chemical vapor deposition concept, is developed for high-quality homoepitaxial growth of Si-doped single-crystalline β -Ga 2 O 3 layers on (010)-oriented native substrates. Substrate annealing in argon atmosphere for 1 min at temperatures below 600 ° C is proposed for the formation of epi-ready surfaces as a cost-effective alternative to th
Flexibility can support the energy transition and improve the efficiency of heat supply to buildings. This study tests price models for the inclusion of heat pumps (HPs) in district heating network (DHN). Various price models were tested in two cases in Sweden. In Sweden, DH companies are increasingly confronted with instances where building owners invest in a HP and only use DH when it is too col
In the context of higher demands on the development of clean energy technologies due to the issue of water shortage in China and the implementation of the 2060 carbon-neutral objective, floating photovoltaic (FPV) systems present novel opportunities for transforming the energy structure through land conservation and enhancement of power generation efficiency compared to conventional solar systems.
The response of clouds to the changes in climate is uncertain, and the representation of the cloud-climate feedback is a key challenge in the global circulation models (GCM) for future climate projections. Factors contributing to this uncertainty include processes that involve particles of various sizes and phases, as well as the interactions between these particles and the surrounding atmosphere.
Public libraries serve as social infrastructures that foster interpersonal connections and promote well-being and cohesion. In order to explore the role played by libraries in the process of social infrastructuring, we conducted a zine-making workshop with librarians. This workshop facilitated collegial conversations and provided an opportunity for participants to familiarize themselves with the cPublic libraries serve as social infrastructures that foster interpersonal connections and promote well-being and cohesion. In order to explore the role played by libraries in the process of social infrastructuring, we conducted a zine-making workshop with librarians. This workshop facilitated collegial conversations and provided an opportunity for participants to familiarize themselves with the c
Bivariate extreme value distributions can be used to model dependence of observations from random variables in extreme levels. There is no finite dimensional parametric family for these distributions, but they can be characterized by a certain one-dimensional function which is known as Pickands dependence function. In many applications the general approach is to estimate the dependence function wi
Haemophilia A (HA) is a hereditary bleeding disorder, characterised by deficiency of coagulation factor VIII (FVIII). Repeated joint bleeds can lead to permanent joint damage. FVIII replacement therapy has a high cost and can reduce but not completely prevent bleeding. This thesis aims to promote personalised treatment and optimised outcomes through a clinical and pharmacokinetic characterisation.
The deliberation that precedes or runs alongside the remaking of cities, buildings and landscapes seem almost by default to generate situations with unsatisfied stakehold-ers, neglected citizen groups or completely ignored voices. What does it mean to find, listen and respond to those concerned by alteration of built environments? Here, in this paper, citizen participation, its ideological and pol
Located in southernmost Sweden, Malmö is part of the quickly developing urban landscape that defnes that part of the country, and it is in close proximity to the Danish border. Like many other coastal and border regions around the globe, this Scandinavian region experiences continuous population profle changes related to migration and is also facing rising sea levels; these conditions demand renew
In this paper, a view will be given on the establishment of large scale science facilities in Lund, Sweden, recognizing some of the recent political changes of this region around the end of 20th century and start of the 21st. During this time the well-renowned social democratic welfare politics in Sweden gave way to a more pragmatic third way politics with clear marks of a neoliberalist housing ma
AimLong-term cognitive decline after out-of-hospital cardiac arrest (OHCA) is still poorly understood. This study describes long-term observer-reported cognitive decline among Danish OHCA survivors, including differences in years since the event, and investigates characteristics and self-reported outcomes associated with observer-reported cognitive decline.MethodsAdults who survived an OHCA from 2AimLong-term cognitive decline after out-of-hospital cardiac arrest (OHCA) is still poorly understood. This study describes long-term observer-reported cognitive decline among Danish OHCA survivors, including differences in years since the event, and investigates characteristics and self-reported outcomes associated with observer-reported cognitive decline.MethodsAdults who survived an OHCA from 2
Samtiden präglas av sociala mediers flöden med allt från kakrecept till konspirationsteorier, algoritmernas enorma makt och samtidigt osynlighet, och en framväxande generativ AI:s kapacitet att sprida lögner, påhittade bilder och videor. Kan källkritik, en metod som en gång utvecklats inom historievetenskapen, vara lösningen på de många utmaningar som samhället står inför? I boken Källkritik: männ
Background Evidence-based medicine recognizes that clinical expertise gained through experience is essential to good medical practice. However, it is not known what beliefs clinicians hold about how personal clinical experience and scientific knowledge contribute to their clinical decision making and how those beliefs vary between professions, which themselves vary along relevant characteristics, Background: Evidence-based medicine recognizes that clinical expertise gained through experience is essential to good medical practice. However, it is not known what beliefs clinicians hold about how personal clinical experience and scientific knowledge contribute to their clinical decision making and how those beliefs vary between professions, which themselves vary along relevant characteristics,
