Filtyp
Background: Evidence on the association between systemic glucocorticoid use and colorectal cancer (CRC) risk is limited. This study aimed to determine whether systemic glucocorticoid use is associated with an increased risk of overall CRC (diagnosed at any age) and early-onset CRC (EOCRC; diagnosed before 50 years of age). Methods: A nationwide cohort study (follow-up: 2005–2018) was conducted usi
Introduction A World Health Organization (WHO) system has recently been introduced to standardize reporting of lymph node fine-needle aspiration biopsy (LN-FNAB) cytopathology. Herein, we analyze its diagnostic performance in a routine setting.Materials and methodsWe reviewed 2274 consecutive lymph node fine-needle aspiration biopsies categorized according to the WHO system. Corresponding histolog
Hydrological Insights: Synergizing Groundwater Models, Remote Sensing, and AI for Water Sustainability offers an in-depth exploration of hydrological modeling and its cutting-edge advancements, presented across six comprehensive sections. Part I establishes the foundational principles and methodologies of hydrological modeling, while Part II delves into sophisticated techniques and tools that enha
Partly overlapping feathers form a large part of birds’ wing surfaces, but in many species the outermost feathers split, making each feather function as an independent wing. These feathers are complex structures that evolved to fulfil both aerodynamic and structural functions. Yet relatively little is known about how the profile shape and microstructures of feathers impact aerodynamic performance.
The Gaussian β-ensemble is a real n-point configuration {xj}n1 picked randomly with respect to the Boltzmann factor e− β 2 Hn, where Hn = ∑i≠j log |xi−1xj| + n ∑ni=112 xi2. It is well known that the point process {xj }n1 tends to follow the semicircle law σ (x) = 21π√(4 − x2 )+ in certain average senses. A Fekete configuration (minimizer of Hn) is spread out in a much more uniform way in the inter
The article examines Europeanisation processes at the Spanish University of Valladolid (UVa) in the years around Spain’s adhesion to the European Communities in 1986. This event has often been seen as key to the Spanish transition to democracy, which had begun after the death of Francisco Franco in 1975. Drawing on a variety of source materials, the article shows that Europeanisation at the UVa in
Background: Natural selection can be a potent contributor to speciation, but how exactly this occurs remains unclear. Studying behavioral isolation and the divergence of mating behaviors among multiple isolated populations can help uncover the importance of divergent adaptation in the evolution of reproductive isolation. Here, we utilize common-garden reared virgin Bahamas mosquitofish (Gambusia h
Declines of insect pollinator diversity in farmlands have neither been halted nor reversed despite large efforts to change the negative trend. One driver of this is agricultural intensification, which has resulted in landscape simplification by loss of non-crop habitats, and increased use of inorganic fertilizers and synthetic pesticides. Consequently, the presence of grazing animals in agricultur
This chapter critically examines the structural forces shaping the emergence and spread of Emerging Infectious Diseases (EIDs), with a particular focus on avian influenza and the poultry supply chain. Moving beyond conventional epicenter thinking, which attributes disease emergence to specific geographic locations, we argue that EIDs should be understood within broader ecological, economic, social
Background: Informal caregivers may experience high levels burden. Prior to COVID-19, loneliness and social isolation, and especially the discordance between them, were recognized for rapid aging-related cognitive decline. The COVID-19 has significantly increased social isolation and loneliness in caregivers. Thus, we aimed to explore the variables that were associated with higher care burden amon
Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency < 1%) predicted damaging coding variation by using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African,
Background: Neurofibrillary tangle pathology is thought to drive neurodegeneration in beta-amyloid positive (A+) cognitively normal (CN) individuals, i.e., preclinical Alzheimer’s disease (AD).However, in beta-amyloid negative (A-) CN, the contribution of tau pathology [primary age-related tauopathy (PART)] to neurodegeneration remains uncertain. We investigate the correlation between tau burden m
Background: The COVID-19 pandemic has renewed attention to the conflicting demands placed on caregivers worldwide. Nowhere is this more evident than in South Asia, where cultural norms and a scarcity of long-term care facilities have made the home the locus of caregiving for individuals with brain health conditions and disabilities. A hidden cost of this informal arrangement is the burden experien
BACKGROUND: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.METHODS
During 2014–2016, Sweden received almost 300,000 people seeking protection. Politically, this asylum reception has been presented as a “crisis”, and a threat to the welfare system as well as Swedish culture. At the same time, many argue that immigration contributes to society's prosperity, both culturally and economically. The aim of this ethnographic study is to examine how problems are formulat
Flame front structure is one of the most fundamental characteristics and, hence, vital for understanding combustion processes. Measuring flame front structure in turbulent flames usually needs laser-based diagnostic techniques, mostly planar laser-induced fluorescence (PLIF). The equipment of PLIF, burdened with lasers, is often too sophisticated to be configured in harsh environments. Here, to sh
This paper describes the Bárány Society Classification OverSight Committee (COSC) position on Cervical Dizziness, sometimes referred to as Cervical Vertigo. This involved an initial review by a group of experts across a broad range of fields, and then subsequent review by the Bárány Society COSC. Based upon the so far published literature, the Bárány Society COSC takes the view that the evidence s
We present a trajectory tracking controller for a quadrotor unmanned aerial vehicle (UAV) configured on SU(2) × R3, and relate this result to a family of geometric tracking controllers on SO(3) × R3. The theoretical results are verified in several simulation examples, and the controller is subsequently implemented in practice and integrated with a simultaneous localization and mapping (SLAM) syste
