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We study the problem of clustering fingerprints with at most p missing values (CMV(p) for short) naturally arising in oligonucleotide fingerprinting, which is an efficient method for characterizing DNA clone libraries. We show that already CMV(2) is NP-hard. We also show that a greedy algorithm yields a min(1+lnn,2+plnl) approximation for CMV(p), and can be implemented to run in O(nl2p) time. We a
Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for
Popular Abstract in Swedish Läkares nattjour innebär långa arbetspass, höga krav, stress och sömnbrist. I dagens läge liknar nattjouren ofta ett nattskift med begränsade möjligheter till vila under arbetspasset. Skiftarbete med nattskift har i många undersökningar visats ge ökad risk för bland annat hjärtinfarkt och diabetes, samt även ha en negativ inverkan på välbefinnande och sömn. Samtliga desAbstract Physicians’ work on night-call entails long and stressful working hours with high demands and disrupted sleep. Incomplete recovery is considered to be the most important link between acute physiological stress reactions, shift work and chronic health effects. Mental and physiological activation naturally accompanies night-call duty, but the crucial issue, from a health perspective, is wh
The article comprises an exemplification of the method the author used in his scientific research as a member of the grant Presa românească şi ideea naţională. Antologie, studiu, dicţionar, dosar critic (The Romanian Press and the National Idea. Anthology, Study, Dictionary, Critical File), 2005-2006, CNCSIS code 782, coordinator of grant Professor Mircea Popa. The author was responsible for the p
Electroweak measurements performed with data taken at the electron positron collider LEP at CERN from 1995 to 2000 are reported. The combined data set considered in this report corresponds to a total luminosity of about 3 fb(-1) collected by the four LEP experiments ALEPH, DELPHI, 13 and OPAL, at centre-of-mass energies ranging from 130 GeV to 209 GeV. Combining the published results of the four L
The risk of losses of income and productive means due to adverse weather can differ significantly among farmers sharing a productive landscape, and is of course hard to estimate, or even "guesstimate" empirically. Moreover, the costs associated with investments in reduced vulnerability to climatic events are likely to exhibit economies of scope. We explore the implications of these characteristics
Several high resolution electrophysiological techniques such as measurements of cell membrane capacitance and amperometry are used to detect exocytotic events. A novel method was developed in this study based on the expression of P2X2 receptor channel in secreting cells. The presence of ATP sensitive channel on the cell membrane permitted the electrical detection of minute (amoles) quantities of A
IT procurement represents a business process of importance, including the ability to articulate requirements that the procurement deals with. Furthermore, specifying requirements is of importance for both procurer, and potential supplier as it functions as central contractual element between the two. The purpose of the article is to show how functional and non-functional requirements are represent
A measurement of the mass difference between top and anti-top quarks is presented. In a 4.7 fb(-1) data sample of proton-proton collisions at root s = 7 TeV recorded with the ATLAS detector at the LHC, events consistent with t (t) over bar production and decay into a single charged lepton final state are reconstructed. For each event, the mass difference between the top and anti-top quark candidat
Background: Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality. We investigated knowledge about key features of HNPCC in at risk individuals and physicians in surgery, gynecology and oncology. Methods: Data were collected using a questionnaire which was answered
Apolipoprotein M (apoM) is composed of 188 amino acids and has an apparent molecular weight of 25 kDa. ApoM belongs to the lipocalin protein superfamily, and is found in all major lipoprotein classes, although the majority of apoM is found in high density lipoprotein, HDL. In apoM, the signal peptide is retained in the mature protein. ApoM with a cleavable signal peptide was constructed. In contra
We study the decays $K\to\pi\pi$ in one-loop two-flavour Chiral Perturbation Theory. We provide arguments why the calculation of the coefficient of the pionic chiral logarithm $\logm = M^2\log M^2$ is unique and then perform the calculation. As a check we perform the reduction of the known three-flavour result. Our result can be used to perform the extrapolation to the physical pion mass of direc
Modern tools in proteomics require access to large arrays of specific binders for use in multiplex array formats, such as microarrays, to decipher complex biological processes. Combinatorial protein libraries offer a solution to the generation of collections of specific binders, but unit operations in the process to isolate binders from such libraries must be automatable to ensure an efficient pro
High-spin states in Nd-139 were investigated using the reaction Zr-96(Ca-48,5n) at a beam energy of 195 MeV and gamma-ray coincidences were acquired with the Euroball spectrometer. Apart from several dipole bands at medium excitation energy, three quadrupole bands have been observed at high spin. Linking transitions connecting two of the high-spin bands to low-energy states have been observed. Cal
Vascular smooth muscle cells are constantly exposed to mechanical force by the blood pressure, which is thought to regulate smooth muscle growth, differentiation and contractile function. We have previously shown that the expression of microRNAs (miRNAs), small non-coding RNAs, is essential for regulation of smooth muscle phenotype including stretch-dependent contractile differentiation. In this s
Context. The Gaia-ESO Survey (GES) is a large public spectroscopic survey at the European Southern Observatory Very Large Telescope. Aims. A key aim is to provide precise radial velocities (RVs) and projected equatorial velocities (v sin i) for representative samples of Galactic stars, which will complement information obtained by the Gaia astrometry satellite. Methods. We present an analysis to e
