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Objective: Metabolic factors have been shown to be associated to severe radiographic knee osteoarthritis (RKOA). However, more knowledge is needed in early clinical knee osteoarthritis (KOA). The aim was to study associations between metabolic factors and radiographic knee osteoarthritis (OA) in individuals with knee pain. A second aim was to study associations between metabolic factors and RKOA i
We consider a generalisation of the Basilica group to all odd primes: the p-Basilica groups acting on the p-adic tree. We show that the p-Basilica groups have the p-congruence subgroup property but not the congruence subgroup property nor the weak congruence subgroup property. This provides the first examples of weakly branch groups with such properties. In addition, the p-Basilica groups give the
Syftet med detta projekt har varit att analysera förutsättningarna för cykling i tätorter av olika storlek. En central del i detta arbete var att tillämpa och utvärdera den GIS-baserade GTCmodellen för beräkning av geografisk tillgänglighet för cykling i kommuner och tätorter av olika storlek (Robertson m.fl., 2018). Projektet har genomförts i samarbete med elva kommuner av olika storlek och struk
Background: Physical activity has been proposed to be beneficial for the symptomatic control of bipolar disorder, but the duration of the effects, sex-specific mechanisms, and impact of exercise intensity are not known. Method: With an observational study design, we followed skiers and age and sex-matched non-skiers from the general population to investigate if participation in a long-distance cro
The recently developed Matched Phase Reassignment (MPR) gives a time-frequency local measure of phase difference between short oscillatory transient signals. However, the resulting phase estimate is not satisfactory as it has poor resolution for high oscillatory frequencies. The MPR is also sensitive to high noise levels and is computationally cumbersome. In this paper, a novel reassignment method
Recent advances in simultaneous estimation of both receiver and sender positions in ad-hoc sensor networks have made it possible to automatically calibrate node positions - a prerequisite for many applications. In man-made environments there are often large planar reflective surfaces that give significant reverberations. In this paper, we study geometric problems of receiver-sender node calibratio
This paper presents the Reassignment Vector Phase Difference Estimator (RVPDE), which gives noise robust relative phase estimates of oscillating transient signals in high noise levels. Estimation of relative phase information between signals is of interest for direction of arrival estimation, source separation and spatio-temporal decoding in neurology as well as for soundscape analysis. The RVPDE
Family doctors and general practitioners (GPs) are the frontline in the management of fatty liver disease. With its high prevalence and strong association with other conditions commonly treated in primary care, the voice of family doctors and GPs has an important role in informing the discussion on the redefinition of fatty liver disease. Primary care uptake of any proposed name will be hampered i
The nasal route is a convenient and simple way to administer peptides to humans. Absorption of the drug, however, requires passage of the substance through the nasal mucosa. This is a possible site of enzymatic degradation of the peptide. It is shown that rabbit nasal mucosa homogenates rapidly degrade the synthetic anti-diuretic hormone analogue desamino1,D-arginine8-vasopressin in vitro. The met
The pharmacologic and pharmacokinetic properties were evaluated in a series of antiuterotonic oxytocin analogs, modified at positions 1, 2, 4, 8 and, in one case, position 9 of the oxytocin (OT) molecule. [Mpa1,D-Tyr2(Et),Val4,Orn8,desGly9]-OT, [Mpa1,Tyr2(Et),Val4,Orn8]-OT and [Mpa1,D-Tyr2,Val4,Orn8]-OT displayed similar plasma clearance rates (Clps) using the constant infusion method in rats. Two
PAM50 intrinsic subtyping and risk of recurrence (ROR) score are approved for risk profiling in postmenopausal women. We aimed to examine their long-term prognostic value in terms of breast cancer-free interval (BCFi) and overall survival (OS) (n = 437) in premenopausal women randomised to 2 years of tamoxifen versus no systemic treatment irrespective of hormone-receptor status. Intrinsic subtypin
Fluorescence sensing plays an increasingly important role in biology and biomedicine. For many practical applications of fluorescent probes, an “off-on” response is preferred. The question of how fluorescence quenching/enhancement occurs is fundamental and of high importance for application and design of new fluorescent probes. The sensing mechanism of an aminorhodamine (TMARh) pH probe is investi
The notion of a superior “civilisation” has been a hallmark of the politics of Western institutions and fringe white supremacists alike. Known ideologically as “civilisationism”, it has occupied a prominent position in the ideology of the Australian far-right. Paying tribute to their settler-colonial origins, the far-right has consistently promoted “white civilisation”, even inspiring terrorist at
Purpose of Review: At elevated levels, the essential element manganese (Mn) is neurotoxic and increasing evidence indicates that environmental Mn exposure early in life negatively affects neurodevelopment. In this review, we describe how underlying genetics may confer susceptibility to elevated Mn concentrations and how the epigenetic effects of Mn may explain the association between Mn exposure e
