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Search for molecular and metabolic mechanisms contributing to impaired bet-cell function Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. I have devoted the work presented in this thesis to attempt to elucidate the coupling of β-cell metabolism to insulin secretion and to look for

https://www.ludc.lu.se/education-training/theses/theseis-2012/siri-malmgren - 2026-09-09

Exocytosis in Type 2 Diabetes - Functional and Genetic Studies of Hormone Secretion Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts

https://www.ludc.lu.se/education-training/theses/theses-2012/sofia-andersson - 2026-09-09

Genetic and Epigenetic Influence on Oxidative Phosphorylation, Islet Function and Type 2 Diabetes in Humans The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistanc

https://www.ludc.lu.se/education-training/theses/theses-2012/anders-h-olsson - 2026-09-09

Melatonin Receptors in pancreatic Islets - Linking a Genetic Variant Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. T2D research has in recent years invested tremendous effo

https://www.ludc.lu.se/education-training/theses/theses-2012/cecilia-nagorny-holmberg - 2026-09-09

Detecting the Vulnerable Plaque Myocardial infarction and stroke, mainly caused by a rupture of an atherosclerotic plaque, are two of the most common causes of mortality and morbidity in the world. Previous studies have pointed out inflammation, drivenby inflammatory lipids, as the keystone in the formation of the rupture prone vulnerable plaque. The risk for a plaque rupture is greatly enhanced i

https://www.ludc.lu.se/education-training/theses/theses-2013/andreas-edsfeldt - 2026-09-09

Adapt, Survive or Die; Metabolic Imbalances and the Enteric Nervous System Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. The GI tract comprises the body’s largest surface to the outside envir

https://www.ludc.lu.se/education-training/theses/theses-2013/ulrikke-voss - 2026-09-09

Estrogen and Serotonin - old dogs, new tricks, implications for pancreatic beta-cell function Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). When activated, these receptors are able to fine-tune islet hormone sec

https://www.ludc.lu.se/education-training/theses/theses-2013/alexander-balhuizen - 2026-09-09

New actors in adipocyte function - Focusing on PDEs, CART and Superantigens Obesity is increasing rapidly in all parts of the world and is now considered to be a global epidemic. Obesity is a major risk factor for several health issues such as type 2 diabetes (T2D) and cardiovascular disease. The adipose tissue is central in the maintenance of a normal energy homeostasis in the body for instance v

https://www.ludc.lu.se/education-training/theses/theses-2013/elin-banke - 2026-09-09

NFAT signaling in chronic and acute inflammation. A novel target for the treatment of diabetic vascular complications and acute pancreatitis? Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel

https://www.ludc.lu.se/education-training/theses/theses-2013/anna-zetterqvist - 2026-09-09

Mechanisms by which variants in the tcf7l2 gene increase the risk of developing type 2 diabetestype 2 diabetesxs Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the deve

https://www.ludc.lu.se/education-training/theses/theses-2014/yuedan-zhou - 2026-09-09

Outcome of ischaemic foot ulcers in patients with diabetes, with or without revascularization The aim of the studies presented in this thesis was to study patients with diabetes and severe peripheral arterial disease (PAD) in regard to outcomes of foot ulcers, factors related to outcomes, and occurrences of new ulcerations and amputations following healing of the initial ulcer. Patients with diabe

https://www.ludc.lu.se/education-training/theses/theses-2014/targ-elgzyri - 2026-09-09

Gestational diabetes mellitus, prevalence in southern Sweden and risk factors for subsequent diabetes Background: Gestational diabetes mellitus (GDM) is associated with risks during pregnancy, during delivery, and in later life with a substantial risk of subsequent diabetes. The worldwide prevalence of GDM is increasing, but varies with differences in diagnostic methods and population characterist

https://www.ludc.lu.se/education-training/theses/theses-2015/claes-ignell - 2026-09-09

Effects of Ca2+, microRNAs and rosuvastatin on insulin-secreting ceta cell function Type 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. The exocy

https://www.ludc.lu.se/education-training/theses/theses-2015/vishal-salunkhe - 2026-09-09

Genetic and Environmental Risk Factors in the Development of Obesity Lifestyle behaviors and genetic variation have clear and distinguishable effects on obesity risk; however, the pattern of disease occurrence within and between populations that differ in their genetic and environmental underpinnings suggests obesity is caused in part by the interaction between adverse lifestyle behaviors and the

https://www.ludc.lu.se/education-training/theses/theses-2015/shafqat-ahmad - 2026-09-09

Metabolomics of weight loss and weight maintenance in obese humans The prevalence of obesity and obesity-related complications are increasing worldwide. Weight loss has shown to improve insulin sensitivity and decrease the risk of developing type 2 diabetes (T2D). Even so, little is known about how metabolites, other than glucoses are affected adter weight loss and weight maintenance treatment. Im

https://www.ludc.lu.se/education-training/theses/theses-2016/nina-geidenstam - 2026-09-09

Causes and consequences of hyperglycemia and glycosuria Type 2 diabetes is one of the world’s major challenges today. Over 400 million people around the globe are diagnosed with diabetes and the consequences to the individual patient and health care systems are significant. Diabetes is a chronic disease and the standard treatment including lifestyle changes, metformin and insulin is in many cases

https://www.ludc.lu.se/education-training/theses/theses-2016/emilia-ottosson-laakso - 2026-09-09

Genome-wide analysis of the DNA methylation landscapes in human tissues The prevalence of type 2 diabetes and obesity is rapidly increasing worldwide. Both pancreatic islets and adipose tissue play an important role in metabolic processes in humans, and dysfunction in these tissues may contribute to the pathogenesis of type 2 diabetes and obesity. Epigenetics is thought to be one of the processes

https://www.ludc.lu.se/education-training/theses/theses-2016/petr-volkov - 2026-09-09

Mechanisms of defective insulin secretion in type 2 diabetes Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological techniques to explore the genetic and cellula

https://www.ludc.lu.se/education-training/theses/theses-2013/taman-mahdi-hamed - 2026-09-09

Development of protocols for metabolomics in biomedical research using chemometrics Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. Because the metabolite levels in a biological sample are the end result of the regulatory processes in cells, metabolomics is a very powerf

https://www.ludc.lu.se/education-training/theses/theses-2010/anders-danielsson - 2026-09-09

Folate - associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status Folate is a B-vitamin that may influence cancer development via its role as methyl donor for DNA synthesis and methylation. Plant foods contain many bioactive compounds including folate and fiber. Results from the Malmö Diet and Cancer (MDC) cohort indicate lower breast cancer r

https://www.ludc.lu.se/education-training/theses/theses-2010/ulrika-ericson - 2026-09-09