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Imbalances in dopamine activity significantly contribute to the pathophysiology of several neuropsychiatric disorders, including addiction, ADHD, schizophrenia, impulse control disorders, and Parkinson's Disease. Neuro(active)steroids, comprising endogenous steroids that finely modulate neuronal activity, are considered crucial regulators of brain function and behavior, with implications in variou
A new theory for the dispersibility enhancing effect of excipient fines for adhesive mixtures for inhalation is presented in this paper, while at the same time the shortcomings of current hypotheses are discussed. The proposed mechanism, denoted the ‘viscoelastic damping effect’, states that the presence of fines particles acts to dampen the collisions between carrier particles during mixing. As a
In this review, we present the current status of phenomenological research on constraining the multi-dimensional proton (and nucleus) structure at high energies through studies of the so-called gluon Wigner distributions. We provide a brief pedagogical introduction into the corresponding theoretical definitions and modelling of exclusive and diffractive scattering observables in terms of the Wigne
Many migratory animals use daylength, or photoperiod, to signal when to migrate and transition between annual phenological states. Whether animals use photoperiod as a temporal or spatial cue while migrating, however, requires additional empirical support. We used hatch-year dunnocks, Prunella modularis (a songbird), caught during their first migration in southern Sweden to elucidate whether migra
Background: Biallelic variants in the major facilitator superfamily domain containing 8 gene (MFSD8) are associated with distinct clinical presentations that range from typical late-infantile neuronal ceroid lipofuscinosis type 7 (CLN7 disease) to isolated adult-onset retinal dystrophy. Classic late-infantile CLN7 disease is a severe, rare neurological disorder with an age of onset typically betwe
This study contributes to geothermal exploration in 1660–1520 Ma old, reworked bedrock in Sweden. Our primary objectives are to constrain the orientation of horizontal stresses, and to discuss implications for geothermal exploration. High-resolution acoustic televiewer image data reveal the downhole distribution of stress indicators (borehole breakouts, drilling-induced fractures and petal centrel
Multimetallic nanoparticles possess a variety of beneficial properties with potential relevance for various applications. These metallic nanoparticles can consist of randomly ordered alloys, which retain the properties of the constituting elements, or ordered intermetallics, which possess extended properties. Depending on the desired application, specific alloys or intermetallic compounds are requ
Topological superconductors are appealing building blocks for robust and reliable quantum information processing. Most platforms for engineering topological superconductivity rely on a combination of superconductors, materials with intrinsic strong spin-orbit coupling, and external magnetic fields, detrimental for superconductivity. We propose a setup where a conventional Josephson junction is lin
Glycosaminoglycans (GAGs) such as heparin and heparan sulfate (HS) play crucial roles in inflammation and wound healing, serving as regulators of growth factors and pro-inflammatory mediators. In this study, we investigated the influence of heparin/HS on thrombin proteolysis and its interaction with the generated 11 kDa thrombin-derived C-terminal peptides (TCPs). Employing various biochemical and
Aims. We aim to determine the influence of the Milky Way's warp on the kinematics of stars across the disc, and therefore measure its precession rate and line of nodes under different assumptions. Methods. We applied Jeans'first equation to a model of a rigidly precessing warp. The predictions of these models were fitted to the average vertical velocities of stars with measured line-of-sight veloc
We introduce a model of hadronization based on invertible neural networks that faithfully reproduces a simplified version of the Lund string model for meson hadronization. Additionally, we introduce a new training method for normalizing flows, termed MAGIC, that improves the agreement between simulated and experimental distributions of high-level (macroscopic) observables by adjusting single-emiss
We study a simple extension of the Standard Model featuring a dark sector with an ultralight pseudo-Nambu-Goldstone boson as a dark matter candidate. We focus on the mass range O(10-20-10-10) eV, relevant for strong gravity applications, and explore its production and evolution in the early Universe. The model is formulated in such a way that dark matter does not couple directly to photons or othe
Heterotopic ossification (HO) in tendons can lead to increased pain and poor tendon function. Although it is believed to share some characteristics with bone, the structural and elemental compositions of HO deposits have not been fully elucidated. This study utilizes a multimodal and multiscale approach for structural and elemental characterization of HO deposits in healing rat Achilles tendons at
BACKGROUND: Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant disorder caused by pathogenic variants in either the TSC1 or TSC2 gene. Common manifestations of TSC have been grouped into major and minor clinical diagnostic criteria and assessed in clinical routine workup. However, case studies point towards the existence of rare disease manifestations and to the potential as
Recently, acqui-hiring, which refers to the acquisitions driven by gaining access to target human capital, has emerged as a proliferating phenomenon in acquisitions of small technology firms. However, we still know little about this phenomenon, particularly outside the community of Silicon Valley. This study sheds new light on the nature of acqui-hiring by focusing on what drives acqui-hiring. Usi
This publication charts the history of the groundbreaking textile design portfolio created by the Argentine collective Buen Diseño para la Industria—formed by geometric abstract artists José Antonio Fernández-Muro, Sarah Grilo, Alfredo Hlito, and Miguel Ocampo—and locates it at the utopic intersection of modernist visual practice and industrial design.The book’s centerpiece is a stunning set of re
An Exhibition History of Latin American Art compiles texts by twenty-one Latin American curators who were asked to select an exhibition that took place in Latin America or focused on the work of Latin American artists and justify its importance, relevance, and influence. The history of Latin American art exhibitions that is thus constructed considers the array of social and institutional contexts
Translated PhD dissertation into Spanish.From the editors: ¿Es el arrepentimiento una forma de memoria?, ¿una manera de narrarnos a nosotros mismos?, ¿un acto de imaginación? Alejandro Cesarco ha desarrollado una práctica artística heterodoxa a partir de recursos como la repetición, la narratividad, la lectura o la traducción. Con este libro, en el que cuestiona un devenir del arte regido por el p
The literature on the prevalence and causes of punishment has been dominated by research into the United States. Yet most of the world's prisoners live elsewhere, and the United States is no longer the country with the world's highest incarceration rate. This article considers what we know about the prevalence and causes of incarceration around the world. We focus on three features of incarceratio
We present a synchronized multisensory dataset for accurate and robust indoor localization: the Lund University Vision, Radio, and Audio (LuViRA) Dataset. The dataset includes color images, corresponding depth maps, inertial measurement unit (IMU) readings, channel response between a 5G massive multiple-input and multiple-output (MIMO) testbed and user equipment, audio recorded by 12 microphones,
