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Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recen
Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related
BACKGROUND: Plasmodium falciparum can be detected by microscopy, histidine-rich-protein-2 (HRP2) capture test or PCR but the respective clinical relevance of the thereby diagnosed infections in pregnant women is not well established.METHODS: In a cross-sectional, year-round study among 839 delivering women in Agogo, Ghana, P. falciparum was screened for in both, peripheral and placental blood samp
IPCC's 2018 Special Report is a stark and bracing reminder of climate threats. Yet literature, reportage, and public discourse reflect imbalanced risk and opportunity. Climate science often understates changes' speed and nonlinearity, but Integrated Assessment Models (IAMs) and similar studies often understate realistic mitigation options. Since ~2010, global mitigation of fossil CO2—including by
Holistic Innovation Policy puts forward a novel framework for the design and analysis of innovation policy. It provides a theoretically anchored foundation for the design of holistic innovation policy by identifying the core problems that tend to afflict innovations and the activities of innovation systems, including the unintended consequences of policy itself. As most of the current innovation p
The Scandinavian region has been at the forefront of energy and environmental policies for decades. While significant effort has been devoted to the supply side and development of technology markets, our study questions the extent to which policy efforts have effectively and explicitly addressed behavioural factors affecting the adoption and the use of low-carbon energy technologies at the individ
This Mutual Learning Exercise (MLE) on Innovation-related Procurement was conducted under the Horizon 2020 Policy Support Facility run by the European Commission’s Directorate-General for Research and Innovation. The 15 countries that participated were: Austria, Belgium - Brussels Region, Estonia, France, Germany, Greece, Latvia, Lithuania, Netherlands, Norway, Portugal, Slovenia, Spain, Sweden an
This thematic report addresses frameworks for innovation related public procurement. It focuses on four specific kinds of procurement, namely (1) direct innovation procurement, (2) catalytic innovation procurement, (3) functional regular procurement, and (4) Pre-Commercial Procurement (PCP). (1) – (3) are also called Innovation-Enhancing Procurement (IEP). The four different kinds of innovation re
Coherent extreme ultraviolet (XUV) light sources are necessary for the investigation of physical processes in the natural length and time scales of atoms. These experiments require a high degree of control of the coherent XUV light. The optical components and techniques, which are available for visible and infrared light, unfortunately cannot be used for controlling XUV light. In this thesis, nove
The European Union (EU) annually publishes an Innovation Union Scoreboard (IUS) as a tool to measure the innovation performance of EU Member States by means of a composite index, called the Summary Innovation Index (SII). The SII is constituted by an average of 25 indicators. The SII is claimed to rank Member States according to their innovation performance. This means that the higher the average
Innovation is often seen as carried out by highly educated labour in R&D intensive companies with strong ties to leading centers of excellence in the scientific world. Seen from this angle innovation is a typical "first world" activity. There however, another way to look at innovation that goes significantly beyond this high-tech picture. In this, broader perspective, innovation-the attempt to
Innovation policy has emerged as a new field of economic policy during the last few decades. This paper explores the rationales for national innovation policies, as laid out in the existing literature on the subject, and considers what the lessons and challenges for theory and practice in this area are. Innovation policy attempts to influence innovation activity, often with the purpose of increasi
