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Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase cascades, e.g., STE11 and STE7, results in increased sporulation. In kar3 mutants Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase cascades, e.g., STE11 and STE7, results in increased sporulation. In kar3 mutants

Objective: The atrioventricular (AV) node plays a central role in atrial fibrillation (AF) as it influences the conduction of impulses from the atria into the ventricles. In the present paper, the statistical dual pathway AV node model, previously introduced by us, is modified so that it accounts for atrial impulse pathway switching even if the preceding impulse did not cause a ventricular activat

The outcome of Design, Innovation and Product development research is often manifested as recommendations in the form of methods, but these do not always find their way into industrial application. This paper elaborates on drivers and barriers for the spread of product development methodology based on 41 interviews with managers, designers, developers and knowledge brokers. Results indicate a rang

If we are being-of-the-world, how can we ever avoid participation? From this question Avhandling / Av_handling (Dissertation / Through_ action) unfolds. It invites to engage in an ongoing continuum of entanglements, where the moment of connection is unavoidable. This invitation demands that we are attentive to our mutual co-constitutiveness, that we take responsibility for what gets excluded as we

History shows that companies that survive in a severe competitive climate are those that are highly adaptable to market and technological changes. Product development is one of the key activities that assure company survival by renewal of its offer to its customers. A scientific formalism has to be created to fulfill two purposes: 1) to ensure that the design and development of a product is succes

The need for a scientific formalism for product realization is the translation of a need onto a product which is developed right in time, at the right costs, and fulfills the specifications set out for the product. To achieve this, most existing methods focus on the customer, or on a key technology as the backbone of product development. In this paper, we claim that efforts must be directed toward