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Interfaces significantly influence the overall material response especially when the area-to-volume ratio is large, for instance in nanocrystalline solids. A well-established and frequently applied framework suitable for modeling interfaces dates back to the pioneering work by Gurtin and Murdoch on surface elasticity theory and its generalization to interface elasticity theory. In this contributio

Background: PSMA PETs can track treatment response in patients with prostate cancer. Recent integration of the RECIP framework with PROMISE v2 allows quantitative assessment of PSMA PETs. While useful for assessing differentially responding lesions, manual measurement and tracking is cumbersome and PSA reliance can be misleading. We evaluated an automated AI-enabled platform, aPROMISE, for longitu

Determining the prevalence of atmospheres on terrestrial planets is a core objective in exoplanetary science. While M dwarf systems offer a promising opportunity, conclusive observations of terrestrial atmospheres have remained elusive, with many yielding flat transmission spectra. We observe four transits of the hot terrestrial planet TOI-1685 b using James Webb Space Telescope (JWST)’s Near Infr

Introduction: Pre-anaesthesia (PA) assessments aim to ensure that anaesthesia is administered as safely and efficiently as possible, minimising risks and improving patient care. While the goal remains the same, the content, delivery, setup and evaluation of PA assessments have evolved over the years, driven by technological opportunities and healthcare systems' needs. Hence, the objective of this

This thesis investigates particle sorting in deterministic lateral displacement (DLD) microfluidic devices, with a focus on how particle size and shape influence sorting behavior. A broad range of synthetic and biological particles were studied, including polystyrene particles, fabricated silicon-based structures, and bacterial samples with diverse physical properties.While DLD has traditionally b

Background: Glomerular filtration rate (GFR) is a key indicator of kidney function, typically estimated using creatinine or cystatin C. When cystatin-C-based eGFR is markedly lower than creatinine-based eGFR, this discrepancy may reflect a selective impairment in the filtration of medium-sized molecules, referred to as Shrunken Pore Syndrome (SPS), or more broadly, Selective Glomerular Hypofiltrat

Introduction: The co-occurrence of lupus nephritis (LN) and chronic kidney disease (CKD) is associated with an excess risk of infection. However, it remains unknown whether the infection risk differs between LN with moderate and advanced CKD (LN-CKD) and other CKD etiologies. Methods: Using data from the Swedish Renal registry 2006-2021, we identified 14,128 patients (median age 68 years, 64% men,

Background: This study aimed to investigate the relevance of various predictors of mortality in late life. Additionally, it explored whether mental health indicators such as depressive symptoms, and cognitive ability, which are known predictors of healthy ageing, are also important markers of mortality. By examining both physical and mental health indicators, we aimed to gain a more comprehensive

OBJECTIVE: A previous placebo-controlled crossover study of intratympanic latanoprost-a drug commonly used for glaucoma treatment-showed positive effects on hearing, tinnitus, and vertigo in patients with long-standing Ménière disease (MD). We aimed to test the safety and efficacy of intratympanic treatment with latanoprost 0.0005% versus placebo in patients with active MD concerning speech discri

Accurate and early detection of Acute Lymphoblastic Leukemia (ALL) is critical for timely intervention and improved patient outcomes. However, the development of reliable deep learning models for hematological image analysis is challenged by limited data availability, dataset bias, and the need for trustworthy predictions in clinical settings. In this study, we propose a Bayesian deep learning fra

Compared with more sophisticated equilibrium theory, naive, non-equilibrium behavioral rules often better describe individuals’ initial play in games. In addition, in repeated play in games, when individuals have the opportunity to learn about their opponents’ past behavior, learning models of different sophistication levels are successful in explaining how individuals modify their behavior in res

Background: Pro-neurotensin (pro-NT) is the stable circulating precursor of neurotensin (NT), a neuropeptide expressed mainly in the central nervous system and small intestine that regulates key physiological processes like fatty acid absorption in the gut and suppresses appetite via central mechanisms. Studies in NT-deficient mice and humans implicate NT in obesity and insulin resistance, highlig

Inter-arm blood pressure differences (IABPDs) can be caused by atherosclerosis. We investigated 29921 men and women aged 50–64years from the nationwide population-based Swedish CArdio Pulmonary bioImage Study (SCAPIS) to evaluate if IABPD is related to risk factors for atherosclerosis and can be used as a marker of atherosclerosis as evaluated by coronary artery calcium score, arterial segment inv

Background: Metastatic disease is the main cause of breast cancer (BC)-related deaths, but prediction of metastases remains challenging especially in the large and diverse group with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative tumors. Molecular tumor features beyond currently used markers could provide important information for stratifying metastatic r

This study examined whether immersive virtual reality (VR) supports second-language vocabulary learning in school-aged children compared to passive computer-based training. Seventy-three Swedish middle-school students learned novel words by assembling objects in VR and by viewing object assembly on a computer screen in a crossover design. Word recall was tested after each condition, and individual