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Evidence suggests the transcription factor GATA-2 is a critical regulator of murine hematopoietic stem cells. Here, we explore the relation between GATA-2 and cell proliferation and show that inducing GATA-2 increases quiescence (G(0) residency) of murine and human hematopoietic cells. In human cord blood, quiescent fractions (CD34(+)CD38(-)Hoechst(lo)Pyronin Y-lo) express more GATA-2 than cycling
A multifactorial grading score (MGS) for invasive squamous cell carcinoma of the uterine cervix has demonstrated its capacity to predict survival in a 5-10 year perspective and metastasis frequencies, and is a valuable tool for treatment schedules. In this study it was shown that the power of prognosis is valid even up to 20 years. In this material from 619 cervical carcinoma patients the MGS scor
In a prospective population-based study, all open hand, wrist, and forearm injuries that were treated during a 10-year period, at hospitals and emergency wards in three Norwegian cities with 225,000 inhabitants, were registered. Injury severity was graded using the abbreviated injury scale (AIS). For moderate injuries (AIS 2) overall incidence (95% CI) was 59 (56-62), incidence among males 92 (86-
A wide range of methods has been proposed for ensuring central fixation in divided visual field studies of cerebral asymmetry. We present some of the problems associated with ensuring central fixation and argue that objectively monitoring fixation location with an eye-tracking device can provide the only accurate and, therefore, acceptable technique. However, the mere use of this equipment does no
We have used behavioural tests to determine the intensity thresholds of colour vision in Bourke's parrots (Neopsephotus bourkii) and budgerigars (Melopsittacus undulatus). We have also examined the relationship between these thresholds and the optical sensitivities of single photoreceptors using morphological methods. Bourke's parrots lose colour vision in brighter light (0.4 cd m(-2)) than budger
OBJECTIVES: To analyse the neuropathological changes behind clinically defined dementia with Lewy bodies (clinDLB) compared with clinically diagnosed Alzheimer's disease (clinAD). METHODS: The prevalence of neuropathological findings in 48 clinDLB and 45 clinAD cases was compared. Sixteen clinDLB and 10 clinAD cases were reassessed with alpha-synuclein staining for Lewy bodies (LB). RESULTS: Alzhe
OBJECTIVE: Acute neck pain developing over hours or a few days is often an alarming symptom that may be due to an inflammatory process or another process affecting the spine or the spinal canal, nerve roots, or peripheral nerves. MATERIALS AND METHODS: Four patients with acute onset of neck pain and dysphagia are presented. They were examined with MRI and CT, barium swallow, and plain radiography
Several physicochemical properties have been determined for N-dodecyllactobionamide (LABA), maltose 6'-O-dodecanoate (C-12-maltose ester), and tetra(ethylene oxide) dodecyl amide (TEDAd). The increase in the flexibility of the sugar headgroup, enabling more possible molecular conformations, reduces the minimum area/molecule at the liquid-vapor interface obtained at the critical micelle concentrati
Background: No studies to specifically determine the prevalence of contact allergy to acrylates/methacrylates in patch tested populations have been published. Objectives: To determine the prevalence of acrylate/methacrylate allergy in all patients tested to the baseline patch test series. Methods: Five acrylate/methacrylate allergens (2-hydroxyethyl methacrylate, methyl methacrylate, ethylene glyc
The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a si
The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency
Two metabentonite suites occur within the Wenlock limestones and marls of Gotland, one within the Slite Formation (M. belophorus to the C. ellesae biozones) and the other in the Mulde Formation (G. nassaM. dubius Biozone). Their geochemical characteristics based on rare-earth element (REE) distributions in apatite crystals separated from the metabentonites suggest origins from three separate volca
A cDNA coding for cystatin D, a human member of the cystatin protein family, has been cloned after specific amplification of reverse- transcribed parotid gland RNA. After replacing the segment encoding the putative 20-residue signal peptide with one encoding the Escherichia coli OmpA leader sequence, the cDNA was expressed in E. coli. The isolated recombinant protein exhibited Ki values of 1.2 nM
Background Fewer electrodes on more easily located places would facilitate electrocardiogram (ECG) recording. To investigate the possibility of simplifying ECG recording in children, we compared the diagnostic conclusions when interpreting standard versus EASI-derived 12-lead ECGs. Our hypothesis was that the variation of the interpretation of standard versus EASI-derived 12-lead ECGs was not grea
The pre-industrial natural carrying capacity is believed to have limited the human population in Iceland to a maximum of fifty to sixty thousand inhabitants. Since AD 1800 the Icelandic population has gradually grown up to nearly 300 thousand in 2005. In this paper a simple approach is used to evaluate the potential population size that the pre-industrial Icelandic environment could possibly susta
The DNA ploidy level of 673 accessions belonging to 238 species of Hieracium have been analyzed by flow cytometry. 222 of the species were of Scandinavian origin as members of the exclusively apomictic H. sectt. Bifida, Hieracium, Oreadea, Tridentata and Vulgata. For the overwhelming majority of the species, the ploidy level (or chromosme number) has never been investigated before. Approximately 5
