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HLA-DQA1 and -DQB1 are strongly associated with type 1 diabetes (T1D), and DQ8.1 and DQ2.5 are major risk haplotypes. Next-generation targeted sequencing of HLA-DQA1 and -DQB1 in Swedish newly diagnosed 1- to 18 year-old patients (n = 962) and control subjects (n = 636) was used to construct abbreviated DQ haplotypes, converted into amino acid (AA) residues, and assessed for their associations wit
The variance in phenotypic trait values is a product of environmental and genetic variation. The sensitivity of traits to environmental variation has a genetic component and is likely to be under selection. However, there are few studies investigating the evolution of this sensitivity, in part due to the challenges of estimating the environmental variance. The livestock literature provides a wealt
Given 1 ≤ q< p< ∞, quantitative weighted Lp estimates, in terms of Aq weights, for vector-valued maximal functions, Calderón–Zygmund operators, commutators, and maximal rough singular integrals are obtained. The results for singular operators will rely upon suitable convex body domination results, which in the case of commutators will be provided in this work, obtaining as a byproduct a new proof
Dispersal ability is key to species persistence in times of environmental change. Assessing a species' vulnerability and response to anthropogenic changes is often performed using one of two methods: correlative approaches that infer dispersal potential based on traits, such as wingspan or an index of mobility derived from expert opinion, or a mechanistic modeling approach that extrapolates displa
The aim of this study was to test the usefulness of polyurethane foam (PUF) passive air samplers as stationary, and, for the first time, as personal samplers for one week’s sampling period of polycyclic aromatic hydrocarbons (PAHs) in occupational air. Routine monitoring of workplace exposure is commonly performed with active sampling. However, active samplers can sometimes be unsuitable; e.g., it
Camping is a recreational activity that links people with their physical surroundings and the environment. Hence, efforts in promoting camping activities may help promote sustainable and accessible recreation and tourism. This research focuses on preferences and barriers for camping in Israel as perceived by frequent, occasional, and noncampers. The findings of an online study with 665 respondents
Från början utbildade universiteten kyrkans prästerskap och från 1600-talet även statens ämbetsmän. Den högre utbildningens fält etablerades under 1800-talet. Då skapades en rad institut vars uppgift var att utbilda det framväxande industrisamhällets expertis i teknik, farmaci, ekonomi m.m. Institutens yrkesinriktade utbildningar byggde på den tidens vetenskaper. När instituten och universitet när
Från och med högskolereformen 1977 infogades ett antal akademiska yrkesutbildningari ett samlat universitets- och högskolesystem. Det gällde grund- och förskollärare, sjuksköterskor, kortare tekniska utbildningar m.fl. som tidigare funnits vid särskilda enheter. Därmed fixerades grunddragen i dagens universitets- och högskolesystem. Detta kapitel skildrar hur universitetslärarkårens expansion, sam
This article analyzes communication practitioners’ accounts to interpret what power effects the strategy discourse has on their “way of seeing” themselves and their work. Through an analysis of 26 interviews with communication practitioners, the findings show that strategy, understood as a discursive body of knowledge, has empowered practitioners by enabling them to produce an understanding of the
Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP-1Rs) in the brain. The findings presented here show that semaglutide modulated food preference, reduced food intake, and caused weight loss without d
Tre digitaliseringsforskare: Dataspårning måste vara transparent och ha nödvändiga ramar för ansvarsutkrävande och nedmontering efteråt.När myndigheter i en kris vill samla in spårningsdata om medborgare måste vi säkerställa nivåerna och omfattningen på ett tydligt och demokratiskt försvarbart sätt.
BACKGROUND: The incidence of cirrhosis for individuals in Sweden has previously been reported as stable/low among European countries. However, Swedish population-based studies are scarce and none of them included data from the most recent decade (2010-2019). We aimed to describe the incidence and aetiology of cirrhosis in the Halland region from 2011 to 2018, and to describe the severity and preva
Objectives: Identification of biological markers that can guide treatment selection is considered to be a viable solution for personalized treatment for patients with psychiatric disorders. This study investigated whether macrophage migration inhibitory factor (MIF) levels at baseline were associated with mindfulness-based group therapy or cognitive behavioral therapy response in patients with mil
Ambitious climate policies have distributional consequences. These require countervailing social policies to keep climate targets acceptable for the electorate. This article analyses data from the European Social Survey as to whether attitudes in relation to climate and welfare policies converge or diverge. It distinguishes four types of social-ecological attitudes: ‘Synergy’ or support for both k
