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Multinational corporations (MNCs) are moving not only their headquarters but also their logistics operations to low-tax jurisdictions to minimise the tax burden. However, the logistics andfiscal domains are guided by different principles. This study aims to explore the cross-country implications of locating facilities in low-tax jurisdictions to takeadvantage of tax arbitrage. A singl
Introduction: To date, the clinical relevance of comorbid amyloid-β (Aβ) pathology in patients with vascular cognitive disorders (VCD) is largely unknown. Methods: We included 218 VCD patients with available cerebrospinal fluid Aβ42 levels. Patients were divided into Aβ+ mild-VCD (n = 84), Aβ− mild-VCD (n = 68), Aβ+ major-VCD (n = 31), and Aβ− major-VCD (n = 35). We measured depression with the Ge
Applying blockchain technology for information sharing in supply chain is driven by many factors, but developing trust is one of the most proposed. However, trust is a multidimensional, intangible concept without an agreed-upon definition. Whereas some argue that trust is the main driver of blockchain technology, others have found a negative relationship. This study focuses on how applying blockch
Background/Aim: Cervical cancer incidence and mortality has decreased after introduction of national screening in Sweden, but women with drug use disorders (DUD) are less likely to participate in screening programs. We aimed to investigate cervical cancer incidence and mortality among women with DUD compared to the general female population in Sweden. Methods: We conducted a cohort study based on
The sustainability of complex resource systems, such as the food, water, and energy (FWE) nexus, is increasingly threatened by climate change impacts, expanding populations, urbanization, and economic instability. However, while research on the topic has burgeoned, studies focused on solution development and implementation, especially at the urban level, have lagged behind. Against this background
Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the acti
Interstitial lung disease (ILD) encompasses a heterogeneous group of more than 200 con-ditions, of which primarily idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia, hypersensitivity pneumonitis, ILD associated with autoimmune diseases and sarcoidosis may present a progressive fibrosing (PF) phenotype. Despite different aetiology and histopathological patterns, the
In the field of engineered organ and drug development, three-dimensional network-structured tissue has been a long-sought goal. This paper presents a direct hydrogel extrusion process exposed to an ultrasound standing wave that aligns fibroblast cells to form a network structure. The frequency-shifted (2 MHz to 4 MHz) ultrasound actuation of a 400-micrometer square-shaped glass capillary that was
Taking inspiration in Barbro Klein’s work, this article focuses on the production of a particular type of institutional lore that we call heritagelore. Heritagelore, as we are advancing the concept here, is composed of the discursive practices within the walls and the organizations of museums. It is the lore that shapes and at least partially structures the types of stories that directors, museum
Background: Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive anecdotal evidence of AR programmes as life-changing experiences, the effects of AR-programmes have not been evaluated scientifically. Here, we present the protocol of the INTERnat
Metal particles are embedded in the polymer to form a polymer composite film as a seed layer on an insulating substrate to overcome the limitation that electrodeposited copper only occurring at the interface between the polymer and the metal electrode. In this work, we successfully developed a Cu-polythiophenes composite film (Cu-PT composite film) through a facile in-situ reduction method, obtain
Traumatic brain injury (TBI) increases the risk of delayed neurodegenerative processes, including Parkinson’s disease (PD). Interleukin-1beta (IL-1β), a key pro-inflammatory cytokine, may promote secondary injury development after TBI. Conversely, neutralizing IL-1β was found to improve functional recovery following experimental TBI. However, the mechanisms underlying the behavioral improvements o
The identity of people living in Central Appalachia is tightly connected with water. Because of the threats to water resources due to coal mining, and most recently, hydraulic fracturing and oil and gas pipeline projects, citizens have formed several nonprofit organizations to preserve or restore rivers and watersheds. Notably, women head the biggest, state-wide, most active and visible of these o
IMPORTANCE Treatment trials require sound knowledge on the natural course of disease. OBJECTIVE To assess clinical features, genetic findings, and genotype-phenotype correlations in patients with retinitis pigmentosa (RP) associated with biallelic sequence variations in the PDE6A gene in preparation for a gene supplementation trial. DESIGN, SETTING, AND PARTICIPANTS This prospective, longitudinal,
Galactic outflows driven by stellar feedback are crucial for explaining the inefficiency of star formation in galaxies. Although strong feedback can promote the formation of galactic discs by limiting star formation at early times and removing low angular momentum (AM) gas, it is not understood how the same feedback can result in diverse objects such as elliptical galaxies or razor thin spiral gal
