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Background: About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Swed
New generation sequencing (NGS) genetic testing is a powerful diagnostic tool and is increasingly used in the clinical workup of patients, especially in unusual presentations or where a positive family history suggests heritable disease. This review addresses the NGS technologies Targeted sequencing (TS), Whole exome sequencing (WES), Whole genome sequencing (WGS), and the use of gene panels or ge
The present prospective cohort study evaluates the effect of three-dimensional (3-D) endoscopy on outcome in transphenoidal endoscopic surgery of pituitary adenomas compared to conventional two-dimensional (2-D) endoscopy. Prospective data was collected from patients undergoing endoscopic surgery for pituitary adenomas before and after the introduction of 3-D endoscopy. Patients, grouped by having
Epi is a humanoid robot developed by Lund University Cognitive Science Robotics Group. It was designed to be used in experiments in developmental robotics and has proportions to give a childlike impression while still being decidedly robotic. The robot head has two degrees of freedom in the neck and each eye can independently move laterally. There is a camera in each eye to make stereovision possi
The electron kinetics in nanowire-based hot-carrier solar cells is studied, where both relaxation and extraction are considered concurrently. Our kinetics is formulated in the many-particle basis of the interacting system. Detailed comparison with simplified calculations based on product states shows that this includes the Coulomb interaction both in lowest and higher orders. While relaxation rate
Based on observations in vivo in guinea-pig and human airways, this review presents plasma exudation as non-sieved transmission of bulk plasma across an unperturbed mucosa that maintains its normal barrier functions. Several steps have led to the present understanding of plasma exudation as a non-injurious response to mucosal challenges. The implication of a swift appearance of all circulating mul
En lundensisk stadsläkare, en dansk diktare, och en pappersfabrikants dotter bor under samma tak – det skulle kunna vara inledningen på ett dålig vits, men är i själva verket början på ett kärleks- och triangeldrama som skakade Lund under andra halvan av artonhundratalet. Arkivarien vid universitetsarkivet Henrik Ullstad skriver om en äktenskapsskandal som slog sönder familjer, krossade en lovandeA town medical officer in Lund, a Danish poet and a paper manufacturer’s daughter living under the same roof – it could be the start to a bad joke, however, it is actually the start of a dramatic love triangle that shook Lund during the second half of the nineteenth century. University archivist Henrik Ullstad writes about a relationship scandal that destroyed families, crushed a promising career,
Immunotherapeutic modalities are currently revolutionizing cancer treatment. In pancreatic cancer, however, early clinical trials have been disappointing. The optimization of immunotherapeutic strategies requires better understanding of the inflammatory tumor microenvironment. Therefore, the aim of our study was to perform a detailed in situ description of lymphocyte infiltration patterns in resec
The 2014 Êzîdî Genocide caused a rupture in the social fabric of the Iraqi religious Êzîdî minority. A search for meaning in the aftermath of violence has caused a group of Şingalî poets to reconstruct memories of the past through their narration in Arabic prose poetry. A narrative analysis has been used on a selection of poems written and interviews conducted with five poets. I investigate their
Your body is not a point particle. The nature and direction of the forces counteracting gravity influence your experience of uniform rectilinear motion- A s does your own orientation in relation to the force of gravity. Sensors in smartphones or other devices can capture these forces, and help establish a connection between the personal experience of motion and the textbook description of forces a
During winter at temperate and high latitudes, the low ambient temperatures, limited food supplies and short foraging periods mean small passerines show behavioural, morphological and physiological adaptations to reduce the risk of facing energy shortages. Peripheral tissues vasoconstrict in low ambient temperatures to reduce heat loss and cold injury. Peripheral vasoconstriction has been observed
The capacity to get rid of excess heat produced during hard work is a possible constraint on parental effort during reproduction [heat dissipation limit (HDL) theory]. We released hard-working blue tits (Cyanistes caeruleus) from this constraint by experimentally removing ventral plumage. We then assessed whether this changed their reproductive effort (feeding rate and nestling size) and levels ofThe capacity to get rid of excess heat produced during hard work is a possible constraint on parental effort during reproduction [heat dissipation limit (HDL) theory]. We released hard-working blue tits (Cyanistes caeruleus) from this constraint by experimentally removing ventral plumage. We then assessed whether this changed their reproductive effort (feeding rate and nestling size) and levels of
Spending the winter in northern climes with short days and cold ambient temperatures (Ta) can be energetically challenging for small birds that have high metabolic and heat loss rates. Hence, maintaining body temperature (Tb) in Ta below thermoneutrality can be energetically costly for a small bird. We still know little about how increased heat production below thermoneutrality affects the level aSpending the winter in northern climes with short days and cold ambient temperatures (Ta) can be energetically challenging for small birds that have high metabolic and heat loss rates. Hence, maintaining body temperature (Tb) in Ta below thermoneutrality can be energetically costly for a small bird. We still know little about how increased heat production below thermoneutrality affects the level a
Animals in seasonal environments must prudently manage energyexpenditure to survive the winter. This may be achieved throughreductions in the allocation of energy for various purposes (e.g.thermoregulation, locomotion, etc.). We studied whether such tradeoffsalso include suppression of the innate immune response, bysubjecting captive male Svalbard ptarmigan (Lagopus mutahyperborea) to bacterial liAnimals in seasonal environments must prudently manage energyexpenditure to survive the winter. This may be achieved throughreductions in the allocation of energy for various purposes (e.g.thermoregulation, locomotion, etc.). We studied whether such tradeoffsalso include suppression of the innate immune response, bysubjecting captive male Svalbard ptarmigan (Lagopus mutahyperborea) to bacterial li
Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework f
Intermittently incubating birds alternate between sessions of egg warming and recesses for foraging during the day, but stay on the nest continuously at night. Hence, energy costs of nocturnal incubation (which increase during longer and colder nights) cannot be replenished until the next day. Night conditions might therefore be expected to affect morning incubation behaviour the day after. We tesIntermittently incubating birds alternate between sessions of egg warming and recesses for foraging during the day, but stay on the nest continuously at night. Hence, energy costs of nocturnal incubation (which increase during longer and colder nights) cannot be replenished until the next day. Night conditions might therefore be expected to affect morning incubation behaviour the day after. We tes
We show that the eccentricities, diameter, radius, and Wiener index of an undirected n-vertex graph with nonnegative edge lengths can be computed in time O(n·(k+⌈logn⌉k)·2klogn), where k is linear in the treewidth of the graph. For every ϵ> 0 , this bound is n1 + ϵexp O(k) , which matches a hardness result of Abboud et al. (in: Proceedings of the Twenty-Seventh Annual ACM-SIAM Symposium on Discret
Background: Maximum exercise workload (WMAX) is today assessed as the first part of Cardiopulmonary Exercise testing. The WMAX test exposes patients with COPD, often having cardiovascular comorbidity, to risks. Our research project was initiated with the final aim to eliminate the WMAX test and replace this test with a predicted value of WMAX, based on a prediction algorithm of WMAX derived from m
