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A well-orchestrated inflammatory reaction involves the induction of effector functions and, at a later stage, an active downregulation of this potentially harmful process. In this study we show that under proinflammatory conditions the noncanonical Wnt protein, Wnt5a, induces immunosuppressive macrophages. The suppressive phenotype induced by Wnt5a is associated with induction of IL-10 and inhibit
Current therapy for haemophilia A is guided by severity of the disease, which in turn is best reflected in patients' endogenous factor VIII activity levels. For patients with severe haemophilia (particularly children), prophylaxis with continuous routine factor replacement has become standard of care in developed countries and is gradually becoming the standard of care in developing countries. The
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative system
BACKGROUND: Serum N-terminal pro-brain natriuretic peptide (NT-proBNP) is regarded as a sensitive marker of cardiovascular disease. Vascular disease plays an important role in cognitive impairment. METHOD: In 447 elderly patients with mental illness, serum NT-proBNP level and the presence or absence of vascular disease according to the medical record were used to categorize patients in different
Aim. To study nurses' compliance to national guidelines (Sweden) for peripheral venous catheters and to establish the complication frequency connected to time in situ and bore size. Background. Worldwide, there are no standard peripheral venous catheters guidelines, and the need for elective replacement has been challenged. Furthermore, the time interval and need for elective change of peripheral
A discussion of the Peace of Kiel of 1814 and the Place of Greenland, Iceland and the Faroe Islands in it.
There is a serious lack of quantitative data regarding exposure-response relationships between occupational risk factors and musculoskeletal elbow and hand disorders. This paper explores such relationships in group-level data from our earlier cross-sectional studies. Prevalence of complaints (Nordic Questionnaire) and diagnoses (physical examination) were recorded in 19 groups of female workers (1
The first Injection Technique workshop brought together endocrinologists and injection experts from around the world in Strasbourg in 1997. From its work came groundbreaking recommendations which advanced best practices in areas such as the use of a skin fold when injecting. The second Injection Technique workshop, with an expanded format including nurses and diabetes educators, took place in Barc
The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six
Popular Abstract in Swedish Svensk sammanfattning av avhandlingen: “Social Insurance, Organization and Hospital Care”. Denna avhandling handlar om incitament och organisation. Det inledande kapitlet sammanfattar avhandlingen samt diskuterar relaterad litteratur. Kapitel 2 är ett bidrag till den teoretiska litteraturen kring socialförsäkringar, kapitel 3 behandlar den optimala organisationen av triThis thesis consists of four chapters where chapter 1 introduces the topics in the following chapters and discusses some related literature. Chapter 2 moves beyond the disability insurance with two types, able and disabled, in Parsons (1996). This is done in two ways: by introducing a third type, the partially disabled, and by allowing for a continuum of types. It is assumed throughout that the i
ABSTRACT: BACKGROUND: Cerebral ischemia results in a rapid increase in contractile cerebrovascular receptors, such as the 5-hydroxytryptamine type 1B (5-HT1B), angiotensin II type 1 (AT1), and endothelin type B (ETB) receptors, in the vessel walls within the ischemic region, which further impairs local blood flow and aggravates tissue damage. This receptor upregulation occurs via activation of the
Introduction to a seminar and a book with four articles and also a revised bibliography celebrating Professor Emeritus Erik Cinthio's 90 years birthday in 2011.
An analysis of particle formation (PF) events over a subarctic mire in northern Sweden was performed, based on number size distributions of atmospheric aerosol particles (10-500 nm in diameter) and ions (0.4-40 nm in Tammet diameter). We present classification statistics for PF events from measurements covering the period July 2005- September 2006, with a break over the winter period. The PF event
