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The green energy transition and circular economy is dependent on a growing and more efficient metal waste stream to address the future increasing demand for metal resources. The drive for increased metal recycling can conflict with occupational health and safety, and the metal recycling industry exposes workers to hazards that can lead to potential health effects such as respiratory, cardiovascula
Safety leadership is considered to be an important factor for safety culture and safety performance. Leaders doubtlessly influence overall safety work and performance; thus, it is important to increase the knowledge what safety leadership entails in a nuclear power production setting. Safety leadership is not a standalone concept, but it exists in an organizational context and is related to systemSafety leadership is considered to be an important factor for safety culture and safety performance. Leaders doubtlessly influence overall safety work and performance; thus, it is important to increase the knowledge what safety leadership entails in a nuclear power production setting. Safety leadership is not a standalone concept, but it exists in an organizational context and is related to system
Matrix cooling is an internal cooling concept for gas turbine blades that combines structural reinforcement with enhanced heat transfer through a rib-crossing lattice geometry. The repeated flow redirection generates strong shear layers, impingement, and vortical structures that significantly influence turbulent transport and heat transfer. This study presents a numerical investigation of turbulen
Sex chromosome evolution is characterized by Y/W degeneration and its consequences for selection on X/Z-linked recessive mutations in the heterogametic sex, yet how functional constraints modulate the evolutionary dynamics of Z–W gametologs remains poorly resolved. We addressed this question in larks (Alaudidae), a lineage carrying enlarged neo-sex chromosomes with multiple evolutionary strata for
Sex chromosomes are central to many ecological and evolutionary processes. Evidence has accumulated that sex chromosome systems vary extensively in age, turnover and transitions, motivating renewed efforts to study the diversity of sex chromosome systems across the tree of life. However, successful genomic detection of sex chromosomes depends on several factors, including the size and divergence t
Converting conventional cropping systems from annual to perennial has been proposed as a strategy to enhance soil organic carbon (SOC) input and storage due to larger root systems and reduced soil disturbance. The mechanisms underlying SOC sequestration are fundamentally mediated by soil microorganisms, which play dual roles: they assimilate labile plant-derived C into microbial biomass that can s
Electrophysiological approaches are widely used to characterize insecticide target sites, whereas behavioral symptoms associated with different modes of action remain less quantitatively explored. Here, we developed a computer vision–based framework to quantify insecticide-induced behavioral responses in the cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae). Convolutional neural networks
ObjectiveFoetal-neonatal alloimmune thrombocytopaenia (FNAIT) is a rare disease, most commonly caused by maternal alloantibodies to human platelet antigen (HPA)-1a that can result in severe bleeding. The present study was designed to determine the frequency of higher risk for HPA-1a alloimmunisation and development of FNAIT among a racially and ethnically diverse cohort of pregnant women.DesignLon
I den här studien utvärderar vi geologiska arkiv och ett flertal geologiska metoder för att identifiera och datera historiska stormflodshändelser längs Hallands kust. Vi har också undersökt en lokal vid Löderup i Skåne som påverkats av en modern stormflod under stormen Babet hösten 2023. Genom fjärranalysbaserat platsurval, fältarbete samt olika laboratorieanalyser inklusive dateringsmetoder testaThis study evaluates geological archives and a suite of proxy methods to identify and date past storm-surge events along the Halland coast, southwest Sweden, with a modern analogue site at Löderup in Scania. Using GIS-based site selection, targeted fieldwork and laboratory analyses including dating methods, we tested which coastal settings and methods best record overwash deposits and whether the
The rate of energy turnover in an animal, metabolic rate, is fundamental to life and determines the energy available for growth, reproduction, and survival. Thus, metabolic rate has been proposed as a mechanism linking physiology to broader ecological patterns. Numerous adaptive frameworks have been proposed to explain how selection acts on metabolic rate, how it relates to life histories, and the
Öland is the third-largest island in the Baltic Sea and one of Sweden’s most popular tourist destinations. The island has only 30 000 permanent residents but hosts around 300 000 seasonal residents and tourists each summer. This creates a strong pressure on local water resources, as private well owners, municipal supplies, and agriculture must compete for limited freshwater. The island is among th
The first generation of medical artificial intelligence (AI) was judged on whether algorithms could match clinicians. The next generation should be judged on whether carefully designed human–AI systems can improve patient outcomes.
Childhood stunting remains a major public health concern in low- and middle-income countries, with persistent sub-national disparities. This study examined spatially varying associations between Height-for-Age z-scores (HAZ) and selected child, maternal, and household factors, and compared Geographically Weighted Regression (GWR), Multi-scale GWR (MGWR) and Geographically Neural Network Weighted R
Rb1 plays an important role in cell cycle progression and therefore may be involved in malignant transformation of colonic cells. The aim of our research was to define the potential role of Rb1 as a prognostic biomarker in tumorigenesis of sporadic colorectal cancer, and to examine the role of miR-106a in Rb1 regulation as it functionally binds to 3'UTR of transcribed mRNA. We examined LOH and pro
Complex diseases, such as advanced cancer, can rarely be treated with a single drug. Combinations of treatments are advised for the majority of types. Noncoding RNAs (ncRNAs), with their simultaneous activities and diversity of targets, often reaching several steps of a pathway, could be the right option to develop new treatment modalities. Because of their multifactorial effects, ncRNA-based ther
Objective To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with a pyknon motif), and to characterise its potential as a biomarker and therapeutic target. Design FLANC expression was analysed in 349 tumours from four cohorts and correlated to clinical data. In a series of multiple in vitro and in vivo mode
BACKGROUND: Emerging evidence suggests that tumour morphological heterogeneity may influence mutational profiles relevant to therapy response. In this pilot study, we aimed to assess whether mutations identified within specific morphological patterns or at the invasion front correlate with shorter time to progression after anti-EGFR therapy, as compared to whole-tissue analysis.METHODS: We investi
Objective of this study was to assess platelet response to clopidogrel and its association with certain single nucleotide polymorphisms (SNPs) of the P2RY12 gene. Several studies have shown that patients with poor in vitro response to clopidogrel have worse outcomes after coronary interventions. Pharmacological response to clopidogrel is mediated by the P2Y12 platelet receptor, therefore, SNPs of
