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Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Gaertner A, Kampinga HH, Morton AJ, Petersén Å, Kirstein J, Bates GP and Wanker EE.Molecular Cell 71 (5): 675-688.(2018)AbstractSelf-propagating, amyloidogenic mutant huntingtin (mHTT) agg

https://www.huntington-research.lu.se/mhtt-seeding-activity-marker-disease-progression-and-neurotoxicity-models-huntingtons-disease - 2026-08-21

Karlsson J, Petersén Å, Gidö G, Wieloch T and Brundin P.Cell Transplantation 14: 301-309 (2005)AbstractAround 80-95% of the immature dopaminergic neurons die when embryonic ventral mesencephalic tissue is transplanted. Cell death occurs both during the preparation of donor tissue and after graft implantation, but the effect of combining successful neuroprotective treatments before and after transp

https://www.huntington-research.lu.se/combining-neuroprotective-treatment-embryonic-nigral-donor-tissue-mild-hypothermia-graft-recipient - 2026-08-21

Araujo IM, Xapelli S, Gil JM, Mohapel P, Petersén Å, Pinheiro PS, Malva JO, Bahr BA, Brundin P and Carvalho CM.Neuroreport 16: 393-396 (2005)AbstractOveractivation of N-methyl-D-aspartate receptors is known to mediate excitotoxicity due to excessive entry of calcium, leading to the activation of several calcium-dependent enzymes. Calpains are calcium-activated proteases that appear to play a role

https://www.huntington-research.lu.se/proteolysis-nr2b-calpain-hippocampus-epileptic-rats - 2026-08-21

Papalexi E, Persson A, Björkqvist M, Petersén Å, Woodman B, Bates GP, Sundler F, Mulder H, Brundin P and Popovic N.European Journal of Neuroscience 22: 1541-1546 (2005)AbstractReductions in testosterone and luteinizing hormone levels and reduced sexual functions have been reported in Huntington's disease (HD) patients. Atrophy of the reproductive organs and loss of fertility have also been observe

https://www.huntington-research.lu.se/reduction-gnrh-and-infertility-r62-mouse-model-huntingtons-disease - 2026-08-21

Gil MAC J, Leist M, Popovic N, Brundin P and Petersén Å.BMC Neuroscience 5: 17 (2004)AbstractBACKGROUND:Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed to play important roles in the pathogenesis of HD. Since no effective treatment is available, this study was designed

https://www.huntington-research.lu.se/asialoerythropoetin-not-effective-r62-line-huntingtons-disease-mice - 2026-08-21

Petersén Å, Puschban Z, Lotharius J, NicNiocaill B, Wiekop B, O´Connor, WT and Brundin P.Neurobiology of Disease 11: 134-146 (2002)AbstractThe present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxy

https://www.huntington-research.lu.se/evidence-dysfunction-nigrostriatal-pathway-r61-line-transgenic-huntingtons-disease-mice - 2026-08-21

Petersén Å, Chase K, Puschban Z, DiFiglia M, Brundin P and Aronin N.Experimental Neurology 175: 297-300 (2002)AbstractA transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with

https://www.huntington-research.lu.se/maintenance-susceptibility-neurodegeneration-following-intrastriatal-injections-quinolinic-acid-new - 2026-08-21

Petersén Å and Brundin P.International Review of Neurobiology 53: 315-339 (2002) SummaryThe Huntington's disease (HD) has stimulated novel clinical drug trials based on the ideas about mechanisms of cell death in the disorder. A recent study investigated the effects of remacemide and coenzyme Q on progression of symptoms in HD. These drugs are an N-methyl-d-aspartate (NMDA) antagonist and a mitoch

https://www.huntington-research.lu.se/huntingtons-disease-mystery-unfolds - 2026-08-21

Petersén Å, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S and Brundin P.European Journal of Neuroscience 14: 1-13 (2001)AbstractHuntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have

https://www.huntington-research.lu.se/mice-transgenic-exon-1-huntingtons-disease-gene-display-reduced-striatal-sensitivity-neurotoxicity - 2026-08-21

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P and Sulzer D.Human Molecular Genetics 10: 1243-1254 (2001)AbstractHuntington's disease (HD) is caused by an expanded CAG repeat in exon 1 of the gene coding for the huntingtin protein. The cellular pathway by which this mutation induces HD remains unknown, although alterations in protein degradation are involved. To study intrinsic

https://www.huntington-research.lu.se/expanded-cag-repeats-exon-1-huntingtons-disease-gene-stimulate-dopamine-mediated-striatal-neuron - 2026-08-21

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, and Sulzer D.Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund, SwedenBrain Research Bulletin 56(3-4): 331-335 (2001)AbstractIn hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) p

https://www.huntington-research.lu.se/brain-derived-neurotrophic-factor-inhibits-apoptosis-and-dopamine-induced-free-radical-production - 2026-08-21

Knowledge for Sustainable Development – Our shared future in times of global conflict and crisis. A link to a detailed programme, as well as a to a summary of all research presentation abstracts, has been sent to all registered participants. 08:30-08:55 | Check-in and mingle with coffeeRegistration at the check-in desk on the first floor of Stadshallen09:00-09:15 | Opening of the conferenceWelcome

https://www.sustainability.lu.se/conference-programme - 2026-08-21

Lund University has observer status to the United Nations Convention on Climate Change (UNFCCC), which means that Lund University can send a delegation of Lund University researchers and students to attend the yearly UN climate change conferences and other meetings and negotiations under the UNFCCC. Below, you find more information about the UNFCCC and how to apply for accreditation. Accreditation

https://www.sustainability.lu.se/sustainability-lund-university/accreditation-unfccc-climate-change-conference - 2026-08-21

Knowledge for Sustainable Development – Our shared future in times of global conflict and crisis  08:30-08:55 Check-in and mingle with coffeeRegistration at the check-in desk on the first floor of Stadshallen 09:00-09:15 Opening of the conferenceKonsertsalenWelcome greetings by Pro Vice-Chancellor Per Mickwitz 09:15-10:30 Plenary Keynotes - Session IKonsertsalenModerator: Lisa Strömbom09:15-09:45

https://www.sustainability.lu.se/research-conference-programme-4-dec-2024 - 2026-08-21

The aim of this workshop series is to look at some of the Sustainable Development Goals of which we currently are furthest away from achieving and to have a joint dialogue in what are the problems, what knowledge do we possess and could we possibly find any solutions together through the work on subject cases. When: Tuesday 2 April 09:00 - 12:00 Where: Teknodromen, Ole Römers väg 1, Lund This is t

https://www.sustainability.lu.se/form/workshop-series-2030-agenda-and-sustainable-development-goals-sustainable-cities-and-communities - 2026-08-21

The aim of this workshop series is to look at some of the Sustainable Development Goals of which we currently are furthest away from achieving and to have a joint dialogue in what are the problems, what knowledge do we possess and could we possibly find any solutions together through the work on subject cases.When: Thursday 30 May 09:00 - 12:00Where: Atmosfären, Geocentrum II, Sölvegatan 12, 223 6

https://www.sustainability.lu.se/form/agenda-2030-graduate-school-workshop-climate-action-and-biodiversity - 2026-08-21

Welcome to participate in the Excellence Programme for Sustainable Development Writing day, were we jointly work together but on our own separate projects! Format: We start with a check-in round where everyone says what they will focus on during the day (individual writing tasks e.g. preparing an abstract for a conference, responding to reviewer comments, drafting a section in a paper etc.). We th

https://www.sustainability.lu.se/form/excellence-programme-sustainable-development-writing-day-10th-june-900-1700 - 2026-08-21

On 7th of November 2023, the 3rd Lund University Conference on Knowledge for Sustainable Development was held at Stadshallen in Lund. The conference highlighted sustainability research at Lund University and different ways to go from research to impact: looking at possibilities that ranges from strategic collaboration with industry, via influence on policy making, to art and music. Opening of the

https://www.sustainability.lu.se/knowledge-sustainable-development/knowledge-sustainable-development-2023-how-make-impact - 2026-08-21

The Sustainability Week programme consists of events organised by staff and students at Lund University and Lund Municipality. If you as a student are interested in organising an event, you can apply via our call for interest that you will find on this page later on. Please read the Criteria for participation before you fill in the expression of interest-form. On this page you can also find tips o

https://www.sustainability.lu.se/sustainabilityweek/student - 2026-08-21

The Sustainability Week programme consists of events organised by staff and students at Lund University and Lund Municipality. If you as a staff member are interested in organising an event, you can apply via our call for interest that you will find on this page later on. Please read the Criteria for participation before you fill in the expression of interest-form. On this page you can also find t

https://www.sustainability.lu.se/sustainabilityweek/organisers - 2026-08-21