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Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2- h glucose level (rs10423928, beta (s.e.m.)
Innate immune cells strongly influence cancer growth and progression via multiple mechanisms including regulation of epithelial to mesenchymal transition (EMT). In this study, we investigated whether expression of the metabolic gene, heme oxygenase-1 (HO-1) in tumor microenvironment imparts significant effects on prostate cancer progression. We showed that HO-1 is expressed in MARCO-positive macro
Synchronous e-learning has received much less research attention, as compared with asynchronous e-learning. Practitioners that consider using and designing synchronous e-learning are in urgent need of guidance. In order to address this need, we propose design exemplars for synchronous e-learning. They are directed towards a primary constituent community of teachers, administrators, managers and de
A method to compute antenna Q using an electromagnetic simulation at a single frequency is described. This method can easily be integrated into global optimization algorithms. In this way the optimization time of some antenna parameters, e.g., bandwidth, may be significantly reduced. The method is validated by direct comparison with the physical bound of the analyzed structure. Numerical examples
A considerable part of black alder swamps in Europe are situated in south Sweden. These swamps are frequently rich in bryophytes, but the variation in species composition is often large between sites. In this study we focus on environmental variables that best predict biodiversity in terms of species number, cover and bryophyte composition. The bryophyte vegetation was analysed in 71 plots of size
So far, 112 polymerid trilobite species/subspecies and 13 agnostoid species/subspecies have been recorded from the Furongian (upper Cambrian) of Scandinavia. For the first time, their zonal occurrences are summarized in a biostratigraphical scheme serving as a practical synopsis for students of this interval in time. Ninety-six of the recorded polymerid trilobite species/subspecies belong to the f
Protein aggregation can lead to major disturbances of cellular processes and is associated with several diseases. We report kinetic and equilibrium data by ThT fluorescence and enzyme-linked immunosorbent assay of sufficient quality and reproducibility to form a basis for mechanistic understanding of amyloid beta-peptide (A beta) fibril formation. Starting from monomeric peptide in a pure buffer s
Background: A high consumption of fruit and vegetables is possibly associated with a decreased risk of colorectal cancer (CRC). However, the findings to date are inconsistent. Objective: We examined the relation between self-reported usual consumption of fruit and vegetables and the incidence of CRC. Design: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 452,755 subjec
Determining requirements process efficiency, and measuring the corresponding monetary impacts, is a challenging but necessary aspect of project management. In this paper, we perform an independent analysis of scoping decisions from a large industrial project with the goal of providing visualizations that facilitate investigations of process efficiency, agility, and the effects of scoping decisions
Background Numerous subsets of patients with chronic lymphocytic leukemia display similar immunoglobulin gene usage with almost identical complementarity determining region 3 sequences. Among IGHV4-34 cases, two such subsets with "stereotyped" B-cell receptors were recently identified, i.e. subset #4 (IGHV4-34/IGKV2-30) and subset #16 (IGHV4-34/IGKV3-20). Subset #4 patients appear to share biologi
Background: Some improvement has been seen in survival after cardiac arrest but the outcome is still poor and 50-70% of patients do not survive despite successful return of spontaneous circulation (ROSC). The cause of death is multifactorial. The majority of patients die from brain injury, but up to 35% die as a result of circulatory failure. Purpose: First, to investigate the release profiles
This paper analyzes and solves an integral and its indefinite Fourier transform of importance in multiple scattering problems of randomly distributed scatterers. The integrand contains a radiating spherical wave, and the two-dimensional domain of integration excludes a circular region of varying size. A solution of the integral in terms of radiating spherical waves is demonstrated. The method empl
Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of C
The performance of 2.7 mu m superficially porous particles at 600 bar and sub-2 mu m fully porous particles at 1000 bar were compared by the Poppe plot method. Theoretical Poppe plots were first constructed for each stationary phase to compare their kinetic performance at different analysis times. The theory was then verified by experiments under the optimized conditions identified from the Poppe
Denna rapport är resultatet av en litteraturstudie där olika faktorers påverkan på gåendet och cyklandet i en urban kontext har undersökts. Utifrån det studerade materialet har faktorerna delats in i grupperna individuella, externa samt resspecifika faktorer. Beslutsprocessen för genomförande av gång- och cykelresor har delats in i faserna resbeslut, färdmedelsval och vägval. De studerade publikat
This paper explores how vehicle speeds are related to equitable, environmental, and economic sustainability of urban areas. This relationship is manifested primarily through associations between vehicle speeds and road crash casualties, severity of pedestrian crashes, generation of harmful emissions, and relative desirability of neighboring land. Reported research findings describing these associa
To efficiently provide an animal with relevant information, the design of its visual system should reflect the distribution of natural signals and the animal’s tasks. In many behavioural contexts, however, we know comparatively little about the moment-to-moment information-processing challenges animals face in their daily lives. In predator avoidance, for instance, we lack an accurate description
