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TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the hig
Abstract in UndeterminedPurpose – This paper seeks to develop an integrated framework to examine how entrepreneurs' work experience is associated with the generation of new business ideas. The framework combines human capital theory with theory and research on entrepreneurial learning.Design/methodology/approach – A statistical analysis on a sample of 291 Swedish entrepreneurs is conducted.Finding
A drawback when hobbing lead crowned helical gears is that the gear tooth will be manufactured with alignment errors, often denoted flank twist. Together with other source deviations, these errors must not exceed the predetermined tolerances if the gear is to be finished hobbed. A simulation model is developed where the hobbing process can be analysed without additional errors resulting from real
Hemophilia A is a congenital, recessive, X-linked bleeding disorder that is managed with infusions of plasma-derived or recombinant factor (F) VIII. The primary considerations in FVIII replacement therapy today are the: 1) immunogenicity of FVIII concentrates, 2) role of longer-acting FVIII products, 3) prophylactic use of FVIII in children and adults with severe hemophilia A, and 4) affordability
Lipase-catalyzed ethanolysis of triolein was studied as a model for biodiesel production. Four lipases were immobilized on porous polypropylene, and ethanolysis reactions were carried out in methyl t-butyl ether. The reaction products were analyzed using gas chromatography. Three of the four lipases studied were efficient in the conversion of triolein to 2-monoolein, but slow in the final step of
Feedforward from measurable disturbances is a powerful complement to feedback control to improve disturbance rejection capability. Recent works have remarked the necessity of a design strategy for those cases where the ideal feedforward controller is not realizable. In this paper, a simple shaping design procedure is presented together with straightforward rules to obtain optimal feedforward contr
Fabry disease (FD) may cause stroke and is reportedly associated with typical brain findings on magnetic resonance imaging (MRI). In a large group of young patients with an acute cerebrovascular event, we wanted to test whether brain MRI findings can serve to suggest the presence of FD.
Energy selective neutron radiography was performed to describe a complex structure in polycrystalline materials. Experiments were performed with currently the highest energy and spatial resolutions achieved simultaneously, by employing a double crystal monochromator for selecting narrow energy bands from the initially polychromatic neutron beam and the neutron absorbing scintillator screen coupled
The females of the four continental Greenomyia Brunetti species in Europe are associated with the males, diagnosed and keyed, providing the first association and description of the females of G. baikalica Zaitzev, 1994 and G. stackelbergi Zaitzev, 1982. Colour photographs of their habitus and line drawings of their female terminalia are provided. Greenomyia mongolica Lagtovka & Matile, 1974 is
All animals flap their wings in powered flight to provide both lift and thrust, yet few human-engineered designs do so. When combined with flexible wing surfaces, the resulting unsteady fluid flows and interactions in flapping flight can be complex to describe, understand, and model. Here, a simple modified actuator disk is used in a quasi-steady description of the net aerodynamic lift forces on s
The purpose of the study was to explore the role of the physical environment for creative employees. The results are based on interviews with office-working digital artists. The physical work environment was considered to offer three types of support for creative work for the participants: functional, psychosocial, and inspirational. Creative processes would find better breeding ground if function
Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis
The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (IcSSc) and diffuse (dcSSc) cutaneous involvement, and the relationships with presence of the SSc-specific auto-antibodies, anti-centromere (ACA), and anti-topoisomerase I (ATA). Four GWAS
ABSTRACT: Streptococcal toxic shock syndrome is most frequently associated with Streptococcus pyogenes of the M1 serotype. Simvastatin protects against M1 protein-induced acute lung damage, although downstream mechanisms remain elusive. Herein, we hypothesized that geranylgeranylation might regulate proinflammatory effects in M1 protein-induced lung injury. Male C57BL/6 mice received the geranylge
Background: Extended-spectrum beta-lactamase (ESBL)-producing bacteria are an escalating problem threatening health. Devastating consequences can result in neonatal intensive care units (NICU) due to these bacteria. The aim of this study was to investigate the efficacy of once-a-week screening (July 2010 to September 2012) versus screening on demand (April 2008 to June 2010). Materials and methods
Understanding the molecular pathways that contribute to the development of tamoxifen resistance is a critical research priority as acquired tamoxifen resistance is the principal cause of poor prognosis and death of patients with originally good prognosis hormone-responsive breast tumors. In this report, we provide evidence that Med1, an important subunit of mediator coactivator complex, is spontan
Constructing and updating an internal model of verticality is fundamental for maintaining an erect posture and facilitating visuo-spatial processing. The judgment of the visual vertical (VV) has been intensively studied in psychophysical investigations and relies mainly on the integration of visual and vestibular signals, although a contribution of postural and somatosensory signals has been repor
Based on scanning planar laser-induced fluorescence of OH, a measurement system with the capability to record time-resolved three-dimensional image sequences of the OH concentration and the flame front is demonstrated on a premixed flame. A dual-mirror scanning system is used to obtain equidistance between the illuminated planes. Non-uniformities in the laser sheet and laser absorption in the flam
