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Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase, critical for B-cell development and function. Mutations that inactivate this kinase were found in families with X-linked agammaglobulinaemia (XLA). In this study the Btk gene was analyzed in 13 registered Greek patients with XLA phenotype originated from 12 unrelated families, in order to provide a definite diagnosis of the XLA. The
On the origin, use and dating of the customary of the cathedral chapter of Lund, i.e. the Consuetudines Lundenses. I have argued that the consuetudines were used by the canons from 30 June 1123 at the latest, the day of inauguration of the crypt church. This seems even more plausible as the prototype of the text, i.e. the Consuetudines Marbacenses, were recently antedated. Furthermore, these circu
One important property of materials is their moisture fixation capacity, i.e., their ability to hold moisture at different relative humidities. The sorption isotherm is one of the main input data in moisture diffusion models, and it can also be used to evaluate properties of the microstructure. We have used four different methods to measure the sorption isotherm of sandstone and porous glass. The
Objective: Lately, desmopressin (dDAVP) administered orally has been demonstrated to be an effective alternative in the management of nocturia in adults. Although the safety profile of dDAVP is well known, much of the experience originates from studies in enuretic children and younger adults, and it may not be readily extrapolated to elderly patients. In order to identify factors associated with a
A two-stage procedure for pretreatment of fast-growing willow with steam has been investigated. The first stage was performed at temperatures in the range 180°C to 220°C for times between 6 and 10 minutes while the second stage was performed at 220°C for 10 minutes. The fibrous material was washed between the two stages to remove the pentosans and thus increase the pentose yield. The pretreatment
I denna skrift ges en heltäckande beskrivning av de byggnadsfysikaliska förhållandena i konstruktioner med golv på mark. Olika fuktbelastningar och deras konsekvenser beskrivs i detalj. Stor vikt läggs vid att skapa förståelse för olika byggnadsfysikaliska samband, speciellt mellan värme och fukt. Vidare tillämpas fuktdimensioneringsmetodiken på tre noggrant beskrivna grundkonstruktioner
Efficacy of veno-right ventricular bypass as a total extracorporeal lung assistance was studied for a period of 24 hours in six healthy pigs with a mean weight of 60 kg. A covalently bonded heparin-coated extracorporeal membrane oxygenation system and a roller pump were used for the bypass. No local or systemic heparin was administered. The bypass was established with an open chest with two 28F ve
Popular Abstract in Swedish Avhandlingen består av fyra kapitel som behandlar olika aspekter av internationell handel och dess effekter på konkurrens och produktivitet. Särskilt behandlas effekterna av EU:s expansion och fördjupade integration. Första kapitlet använder den så kallade gravitationsmodellen för att analysera hur integrationsprocessen av de Central- och Östeuropeiska länderna i EU haThis thesis consists of four papers on trade, competition and productivity with particular emphasis on the effects of various aspects of the deepening and widening of the European Union. The first paper Trade Creation, Diversion and Displacement of the EU Enlargement Process provides an assessment of the effects of the EU enlargement process on trade. A new method of estimating the gravity model
PURPOSE. To compare a fundus image-analysis algorithm for automated detection of hemorrhages and microaneurysms with visual detection of retinopathy in patients with diabetes. METHODS. Four hundred fundus photographs (35-mm color transparencies) were obtained in 200 eyes of 100 patients with diabetes who were randomly selected from the Welsh Community Diabetic Retinopathy Study. A gold standard re
Ca2+ sensitization of smooth muscle contraction involves the small GTPase RhoA, inhibition of myosin light chain phosphatase (MLCP) and enhanced myosin regulatory light chain (LC20) phosphorylation. A potential effector of RhoA is Rho-associated kinase (ROK). The role of ROK in Ca2+ sensitization was investigated in guinea-pig ileum. Contraction of permeabilized muscle strips induced by GTPgammaS
Real world systems are normally considered as hierarchically organized, for example, we see those as hierarchies of systems including subsystems. Examples on this can be seen in organizations where people act in environments and carry within themselves their own internal subsystem of thinking processes. Another example relates to robotics where robots may be seen as hierarchical constructions, bot
Simultaneous measurements of early flame speed and local measurements of the major parameters controlling the process are presented. The early flame growth rate was captured with heat release analysis of the cylinder pressure. The local concentration of fuel or residual gas were measured with laser induced fluorescence (LIF) on isooctane/3-pentanone or water. Local velocity measurements were perfo
Popular Abstract in Swedish Schizofreni är en kronisk och handikappande sjukdom som karakteriseras av allvarliga men fluktuerande symtom, med återkommande akuta episoder. Sjukdomen är förknippad med reducerad kognitiv och social funktionsförmåga. Patienterna vilka i regel insjuknar i unga år, bibehåller vanligtvis kvarstående restsymtom och därmed associerade stigma fram till ålderdomen. Det överObjective: To explore the long-term course and to study factors of potential relevance for the treatment and rehabilitation process of patients with schizophrenia and schizophrenia-like disorders. Specific issues concerned cognitive reduction, tardive dyskinesia (TD), prolactin-induced side effects, remission and lack of insight. Method: A naturalistic multicenter study of 225 patients, diagnosed
Abstract is not available.
BACKGROUND: Death of smooth muscle cells in the atherosclerotic plaques makes the plaques more prone to rupture, which can initiate an acute ischemic event. The development of atherosclerosis includes the migration of immune cells e.g. monocytes/macrophages and T lymphocytes into the lesions. Immune cells can release antimicrobial peptides. One of these, human cathelicidin antimicrobial peptide hC
In the article a simulation model of pricing behaviour on the gasoline market in Sweden is reported. First a brief review of price-changes during a historical period is provided. Next the model is presented in three steps with increasing level of detail for each step. The companies in the model are assumed to have three goals but only one variable for action
In this paper, the further development of a silicon flowthrough microdispenser is described. Previously reported designs of the dispenser used bimorph, and later multilayered, piezoelectric actuator elements for the generation of droplets. The introduction of a multilayered actuator significantly reduced the voltage amplitude needed to dispense droplets. Dispenser properties relevant for chemical
