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Background: Diffuse large B-cell lymphoma (DLBCL) exhibits immunological heterogeneity that influences outcomes of immunochemotherapy, with CD8+ T cells playing a critical role in patient prognosis. Methods: We integrated single-cell and bulk transcriptome data to establish a CD8⁺ T cell–associated prognostic signature. Single-cell RNA sequencing data from 29 samples (28 individuals), including DL
OBJECTIVE: To describe the distribution of HIV-1 variants in population-based national surveys conducted in sub-Saharan African countries between 2015 and 2022.DESIGN: Multicountry analysis.METHODS: Sixteen population-based national surveys, conducted between 2015 and 2022, were analyzed. Survey participants were eligible if HIV genotyping was successful. In most countries, people with HIV (PWH) w
Background Approximately one-third-of patients with transient new-onset atrial fibrillation (AF) during hospitalization for noncardiac surgery or medical illness will have recurrent AF within 1 year when assessed using two 14-day ECG monitors. The proportion of patients that would be diagnosed with recurrent AF with less monitoring is unknown. Methods We used data from a prospective cohort of part
How can different value chain actors mitigate threats or benefit from moments of volatility? This question has become essential as global value chains are restructuring, with policymakers and management scholars calling for increasing value chain resilience. Surveying geographers’ recent contributions, this paper develops a geographical political economy of value chain resilience, which helps expl
Much of the hype about AI exploits the fact that human cognition, language, and categorization rely on imaginative scaffolding. Some degree of metaphor and conceptual borrowing should not be seen as a methodological failure. Law does not meet AI as a blank slate. It reaches for metaphors and other imaginative patterns that make the unfamiliar legible, channeling attention toward certain features a
Immune thrombocytopenia (ITP) is characterized by the overproduction of antiplatelet autoantibodies. Although B-cell depletion therapies show promise in ITP, their high relapse rates suggest a potential de novo breakdown of tolerance during an early stage of B-cell development. Here, we investigated how central B-cell tolerance mechanisms affect autoantibody production in ITP. Paired single-cell R
Weight stigma is a social justice issue that can lead to weight-based discrimination and mistreatment. In pregnancy, emerging evidence has highlighted that weight stigma predominantly affects individuals who have larger bodies and is associated with postpartum depression and avoidance of healthcare. Racial and ethnic background will influence perceptions of, and responses to, weight stigma and the
Purpose: Diffusion MRI probes tissue microstructure, but low SNR and limited resolution hinder detection of features and parameter estimates. We introduce slice excitation with random overlap (SERO), which enables variable repetition times (TRs) and diffusion weighting within a single shot. This acquisition supports super-resolution reconstruction of baseline signal ((Formula presented.)), diffusi
Nineteen new, presumably apomictic species of Hieracium sect. Tridentata, namely Hieracium anisodontum, H. bicoloriceps, H. disparifolium, H. ditrichum, H. erectifolium, H. ferox, H. lapsanae, H. luteoviride, H. megaplicatum, H. multifolium, H. paer-haraldii, H. perpendiculum, H. phaeochlorum, H. prasiniceps, H. semirigidum, H. serriolum, H. spinophytoides, H. svensonii, H. xantholineatum, and one
A wideband, compact monopolar patch antenna with an inherent filtering response is presented in this paper. By employing a slot-assisted mode-tailoring technique, the field distributions of several higher-order modes at the patch center are engineered to produce a stable monopolar radiation pattern with enhanced bandwidth. The closed-form analysis indicates that increasing the current intensity at
Paper on Charles XII as he was portrayed by Gösta Ekman the older in the film Charles XII (1925).
Management of neonates with hypoplastic left heart syndrome following the Norwood procedure seeks to optimize systemic oxygen delivery while maintaining an appropriate distribution between systemic and pulmonary blood flow. The objective of this study was to quantify actively circulating blood volume, total cardiac output, the pulmonary-to-systemic blood flow ratio (Qp/Qs), and vascular resistance
Ferroelectricity in Hf0.5Zr0.5O2 (HZO) originates from a polymorphic landscape where the metastable orthorhombic phase competes with monoclinic and tetragonal forms, making functional properties highly sensitive to structural instability. Recent strategies have exploited ionic-vacancy mechanisms, either through redox interactions with the environment or by employing ferroionic heterostructures, to
Self-care has emerged as a critical practice of resistance in the current era of far-right resurgence. Building particularly on Audre Lorde’s insights, scholars, activists, and cultural workers conceptualize self-care as an act of political defiance and a strategy of collective survival. This article brings three different views of self-care into conversation. Beginning with Lorde's vision and con
This paper examines the electoral impact of economic growth through increased foreign tourism using data from Croatia. To identify causal effects, the paper applies an instrumental variable strategy, which uses variation in the ruggedness of the local terrain to estimate the network of least-cost paths. The results suggest that an increase in foreign tourism reduces nationalist voting, and increas
The paper analyses the legal framework for the collection and distribution of remote sensing data, particularly in the field of sustainable development and environmental protection at the European level. The research firstly focuses on the historical evolution of space law at the international, European, and national levels, starting from the 1970s. In parallel, environmental law has rapidly devel
